Purification and characterization of Shiga toxin 2f, an immunologically unrelated subtype of Shiga toxin 2. [PDF]
PLoS ONE, 2013 BACKGROUND: Shiga-like toxin 2 (Stx2) is one of the most important virulence factors in enterohaemorrhagic Escherichia coli (E. coli) strains such as O157H7. Subtypes of Stx2 are diverse with respect to their sequence, toxicity, and distribution.
Craig Skinner +4 more
doaj +5 more sources
Shiga toxin 2 translocation across intestinal epithelium is linked to virulence of Shiga toxin-producing Escherichia coli in humans. [PDF]
Microbiology (Reading), 2018 Shiga toxin-producing Escherichia coli (STEC) are characterized by the release of potent Shiga toxins (Stx), which are associated with severe intestinal and renal disease.
Tran SL +3 more
europepmc +7 more sources
Down-Regulation of Renal Klotho Expression by Shiga Toxin 2 [PDF]
Kidney & Blood Pressure Research, 2014 Background/Aims: Shiga toxin 2 may trigger classical hemolytic uremic syndrome (HUS) eventually leading to renal failure. Klotho, a transmembrane protein, protease and hormone mainly expressed in kidney is involved in the regulation of renal phosphate ...
Martina Feger +7 more
doaj +4 more sources
An Improved Method for the Sensitive Detection of Shiga Toxin 2 in Human Serum. [PDF]
Toxins (Basel), 2018 Shiga toxins (Stx) released by Stx-producing E. coli (STEC) are virulence factors that are most closely associated with hemolytic uremic syndrome (HUS), a life-threatening complication of intestinal infections by STEC.
He X +5 more
europepmc +7 more sources
Frontiers in Microbiology, 2016 Shiga toxin producing Escherichia coli may damage the central nervous system before or concomitantly to manifested hemolytic uremic syndrome symptoms.
Luciana eD’Alessio +6 more
doaj +2 more sources
Phylogenetic analysis of Shiga toxin 1 and Shiga toxin 2 genes associated with disease outbreaks [PDF]
BMC Microbiology, 2007 Background Shiga toxins 1 and 2 (Stx1 and Stx2) are bacteriophage-encoded proteins that have been associated with hemorrhagic colitis, hemolytic uremic syndrome and other severe disease conditions.
Farrell Larry D +5 more
doaj +3 more sources
Genome-wide siRNA screen identifies UNC50 as a regulator of Shiga toxin 2 trafficking. [PDF]
J Cell Biol, 2017 Shiga toxins 1 and 2 (STx1 and STx2) undergo retrograde trafficking to reach the cytosol. Early endosome-to-Golgi transport allows the toxins to evade degradation in lysosomes. Targeting this trafficking step has therapeutic promise, but the mechanism of
Selyunin AS +3 more
europepmc +2 more sources
A translational murine model of sub-lethal intoxication with Shiga toxin 2 reveals novel ultrastructural findings in the brain striatum. [PDF]
PLoS ONE, 2013 Infection by Shiga toxin-producing Escherichia coli causes hemorrhagic colitis, hemolytic uremic syndrome (HUS), acute renal failure, and also central nervous system complications in around 30% of the children affected. Besides, neurological deficits are
Carla Tironi-Farinati +5 more
doaj +2 more sources
Characterizing RecA-independent induction of Shiga toxin2-encoding phages by EDTA treatment. [PDF]
PLoS ONE, 2012 The bacteriophage life cycle has an important role in Shiga toxin (Stx) expression. The induction of Shiga toxin-encoding phages (Stx phages) increases toxin production as a result of replication of the phage genome, and phage lysis of the host cell also
Lejla Imamovic, Maite Muniesa
doaj +4 more sources
Characterization of Shigella sonnei Isolate Carrying Shiga Toxin 2-Producing Gene. [PDF]
Emerg Infect Dis, 2015 To the Editor: Shigella sonnei causes a bacillary dysentery called shigellosis. Shiga toxins 1 (Stx1) and 2 (Stx2) are mainly produced by Shiga toxin–producing Escherichia coli (STEC), but Stx1 can also be produced by S.
Nyholm O +7 more
europepmc +2 more sources