Down-Regulation of Renal Klotho Expression by Shiga Toxin 2 [PDF]
Kidney & Blood Pressure Research, 2014 Background/Aims: Shiga toxin 2 may trigger classical hemolytic uremic syndrome (HUS) eventually leading to renal failure. Klotho, a transmembrane protein, protease and hormone mainly expressed in kidney is involved in the regulation of renal phosphate ...
Martina Feger +7 more
doaj +5 more sources
Geldanamycin Enhances Retrograde Transport of Shiga Toxin in HEp-2 Cells. [PDF]
PLoS ONE, 2015 The heat shock protein 90 (Hsp90) inhibitor geldanamycin (GA) has been shown to alter endosomal sorting, diverting cargo destined for the recycling pathway into the lysosomal pathway. Here we investigated whether GA also affects the sorting of cargo into
Anne Berit Dyve Lingelem +4 more
doaj +5 more sources
Purification and characterization of Shiga toxin 2f, an immunologically unrelated subtype of Shiga toxin 2. [PDF]
PLoS ONE, 2013 BACKGROUND: Shiga-like toxin 2 (Stx2) is one of the most important virulence factors in enterohaemorrhagic Escherichia coli (E. coli) strains such as O157H7. Subtypes of Stx2 are diverse with respect to their sequence, toxicity, and distribution.
Craig Skinner +4 more
doaj +4 more sources
Phylogenetic analysis of Shiga toxin 1 and Shiga toxin 2 genes associated with disease outbreaks [PDF]
BMC Microbiology, 2007 Background Shiga toxins 1 and 2 (Stx1 and Stx2) are bacteriophage-encoded proteins that have been associated with hemorrhagic colitis, hemolytic uremic syndrome and other severe disease conditions.
Farrell Larry D +5 more
doaj +3 more sources
Characterizing RecA-independent induction of Shiga toxin2-encoding phages by EDTA treatment. [PDF]
PLoS ONE, 2012 The bacteriophage life cycle has an important role in Shiga toxin (Stx) expression. The induction of Shiga toxin-encoding phages (Stx phages) increases toxin production as a result of replication of the phage genome, and phage lysis of the host cell also
Lejla Imamovic, Maite Muniesa
doaj +3 more sources
Molecular Damage and Induction of Pro-inflammatory Cytokines in Human Endothelial Cells Exposed to Shiga toxin 1, Shiga toxin 2 and alfa-sarcin [PDF]
Infection and Immunity, 2007 Treatment of human endothelial cells with Shiga toxin 1 and 2 leads to the upregulation of genes encoding proinflammatory molecules involved in the pathogenesis of hemolytic-uremic syndrome.
P. G. Petronini +15 more
core +6 more sources
The Design, Synthesis and Evaluation of Multivalent Heterobifunctional Ligands Specific for Shiga Toxin 1 and Shiga Toxin 2 [PDF]
, 2014 Hemolytic uremic syndrome (HUS) is a potential life-threatening condition caused by infection with Shiga toxin-producing Escherichia coli O157:H7. There are two major types of Shiga toxins, namely, Shiga toxin 1 (Stx1) and Shiga toxin 2 (Stx2), of which,
Jacobson, Jared M
core +3 more sources
The Effect of Mitomycin C on Induction of Shiga Toxin Production in Clinical STEC Isolates [PDF]
ToxinsEarly determination of the Shiga toxin type of Shiga toxin-producing Escherichia coli (STEC) is crucial for guiding STEC-infected patients for proper and timely treatment and patient care.
Surangi H. Thilakarathna +2 more
doaj +2 more sources
Untersuchungen zur Sensitivität von humanen Zellen mit unterschiedlichem Gehalt an Shiga Toxin-Rezeptoren gegenüber Shiga Toxin 2 [PDF]
, 2012 Storck W. Untersuchungen zur Sensitivität von humanen Zellen mit unterschiedlichem Gehalt an Shiga Toxin-Rezeptoren gegenüber Shiga Toxin 2.
Storck, Wiebke
core +3 more sources
Shiga toxin 2 translocation across intestinal epithelium is linked to virulence of Shiga toxin-producing Escherichia coli in humans. [PDF]
Microbiology (Reading), 2018 Shiga toxin-producing Escherichia coli (STEC) are characterized by the release of potent Shiga toxins (Stx), which are associated with severe intestinal and renal disease. Although all STEC strains produce Stx, only a few serotypes cause infection in humans.
Tran SL +3 more
europepmc +6 more sources