Results 31 to 40 of about 22,441 (226)

Specific Rab GTPase-activating proteins define the Shiga toxin and epidermal growth factor uptake pathways [PDF]

, 2007
Rab family guanosine triphosphatases (GTPases) together with their regulators define specific pathways of membrane traffic within eukaryotic cells. In this study, we have investigated which Rab GTPase-activating proteins (GAPs) can interfere with the ...
Evelyn Fuchs, Francis A. Barr, Yoshimura, S. I., Spooner, Robert A., Haas, A. K., Robert A. Spooner, Shin-ichiro Yoshimura, Hass, Alexander K., Fuchs, Evelyn, Lord, Mike, Barr, F. A., Fuchs, E., Lord, J. M., Haas, Alexander K., Spooner, R. A., J. Michael Lord, Alexander K. Haas, Yoshimura, Shin-ichiro, Barr, Francis A.   +18 more
core   +1 more source

Differential binding of Shiga toxin 2 to human and murine neutrophils [PDF]

Journal of Medical Microbiology, 2007
Shiga toxins (Stx1 and Stx2) are responsible for initiating haemolytic uraemic syndrome, a serious extraintestinal complication caused by enterohaemorrhagicEscherichia coliO157 : H7 infection in humans. Shiga toxins are classical AB5-type exotoxins, consisting of a globotriaosylceramide (Gb3)-binding B subunit pentamer and an enzymic A subunit.
Thomas P, Griener, George L, Mulvey, Paola, Marcato, Glen D, Armstrong   +3 more
openaire   +2 more sources

Intimin, tir, and shiga toxin 1 do not influence enteropathogenic responses to shiga toxin-producing Escherichia coli in bovine ligated intestinal loops [PDF]

, 2002
Shiga toxin-producing Escherchia coli (STEC) comprises a group of attaching and effacing (A/E) enteric pathogens of animals and humans. Natural and experimental infection of calves with STEC may result in acute enteritis or subclinical infection ...
Campbell, June, June Campbell, Timothy S. Wallis, Phillips, A D, Oswald, Eric, Campbell, J, Olivier Marchès, Phillips, Alan D., Wallis, Timothy S., Stevens, M P, Veronika Huter, Gad Frankel, Huter, V, Wallis, T S, Mark P. Stevens, Alan D. Phillips, Marchès, Olivier, Huter, Veronika, Marches, O, Oswald, E, Frankel, Gad, Stevens, Mark P., Frankel, G, Eric Oswald   +23 more
core   +1 more source

An Improved Method for the Sensitive Detection of Shiga Toxin 2 in Human Serum. [PDF]

Toxins (Basel), 2018
Shiga toxins (Stx) released by Stx-producing E. coli (STEC) are virulence factors that are most closely associated with hemolytic uremic syndrome (HUS), a life-threatening complication of intestinal infections by STEC. Stx have to enter into the circulatory system before they are delivered to target organs and cause damage.
He X, Ardissino G, Patfield S, Cheng LW, Silva CJ, Brigotti M.   +5 more
europepmc   +6 more sources

Baicalin Inhibits the Lethality of Shiga-Like Toxin 2 in Mice [PDF]

Antimicrobial Agents and Chemotherapy, 2015
ABSTRACT Shiga-like toxins (Stxs), produced by pathogenic Escherichia coli , are a major virulence factor involved in severe diseases in human and animals. These toxins are ribosome-inactivating proteins, and treatment for diseases caused by them is not available.
Jing, Dong, Yong, Zhang, Yutao, Chen, Xiaodi, Niu, Yu, Zhang, Cheng, Yang, Quan, Wang, Xuemei, Li, Xuming, Deng   +8 more
openaire   +2 more sources

Shiga toxin 2-induced intestinal pathology in infant rabbits is A-subunit dependent and responsive to the tyrosine kinase and potential ZAK inhibitor imatinib

Frontiers in Cellular and Infection Microbiology, 2012
Shiga toxin producing Escherichia coli (STEC) are a major cause of food-borne illness worldwide. However, a consensus regarding the role Shiga toxins play in the onset of diarrhea and hemorrhagic colitis is lacking.
Samuel eStone, Cheleste eThorpe, Amrita eAhluwalia, Amrita eAhluwalia, Arlin eRogers, Fumiko eObata, Aimee eVozenilek, Glynis eKolling, Anne eKane, Bruce eMagun, Dakshina eJandhyala   +10 more
doaj   +1 more source

Comparative genomics of Shiga toxin encoding bacteriophages [PDF]

, 2012
Background Stx bacteriophages are responsible for driving the dissemination of Stx toxin genes (stx) across their bacterial host range. Lysogens carrying Stx phages can cause severe, lifethreatening disease and Stx toxin is an integral virulence factor.
Alan J McCarthy, Darby Alistair C, Alistair C Darby, Allison Heather E, Rooks David J, Rooks, David, Smith, Darren, Paul CM Fogg, Thomson, Nicholas, David J Rooks, Smith Darren L, McCarthy Alan J, McCarthy, Alan, Heather E Allison, Darren L Smith, Allison, Heather, Fogg Paul CM, Nick R Thomson, Fogg, Paul, Darby, Alistair, Thomson Nick R   +20 more
core   +1 more source

Immunoprophylactic Potential of Cloned Shiga Toxin 2 B Subunit [PDF]

The Journal of Infectious Diseases, 2001
The Shiga toxins Stx1 and Stx2 contribute to the development of enterohemorrhagic O157:H7 Escherichia coli-mediated colitis and hemolytic-uremic syndrome in humans. The Stx2 B subunit, which binds to globotriaosylceramide (GB3) receptors on target cells, was cloned.
P, Marcato, G, Mulvey, R J, Read, , Vander Helm K, P N, Nation, G D, Armstrong   +5 more
openaire   +2 more sources

Detection of E. coli O157:H7 and Shigella dysenteriae toxins in clinical samples by PCR-ELISA

Brazilian Journal of Infectious Diseases, 2015
Shiga toxin producing bacteria are potential causes of serious human disease such as hemorrhagic colitis, severe inflammations of ileocolonic regions of gastrointestinal tract, thrombocytopenia, septicemia, malignant disorders in urinary ducts, hemolytic
Jafar Amani, Askary Ahmadpour, Abbas Ali Imani Fooladi, Shahram Nazarian   +3 more
doaj   +1 more source

Prevalence and genetic characterization of shiga toxin-producing Escherichia coli isolates from slaughtered animals in Bangladesh [PDF]

, 2008
To determine the prevalence of Shiga toxin (Stx)-producing Escherichia coli (STEC) in slaughter animals in Dhaka, Bangladesh, we collected rectal contents immediately after animals were slaughtered.
Beumer, R.R., Boer, E., de, de Boer, E., Islam, M.A., Talukder, K.A., Zwietering, M.H., Mondol, A.S., Heuvelink, A.E.   +7 more
core   +1 more source