Shiga Toxin 2–Specific but Not Shiga Toxin 1–Specific Human Monoclonal Antibody Protects Piglets Challenged with EnterohemorrhagicEscherichia coliProducing Shiga Toxin 1 and Shiga Toxin 2 [PDF]
The Journal of Infectious Diseases, 2010 Escherichia coli strains that produce Shiga toxin 2 (Stx2) are isolated from hemolytic-uremic syndrome (HUS) cases more frequently than are strains that produce both Shiga toxin 1 (Stx1) and Stx2, whereas strains that produce only Stx1 are rarely isolated from HUS cases.
Kwang-Il, Jeong +2 more
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Induction by Sphingomyelinase of Shiga Toxin Receptor and Shiga Toxin 2 Sensitivity in Human Microvascular Endothelial Cells [PDF]
Infection and Immunity, 2003 ABSTRACT Shiga toxin-producing enterohemorrhagic Escherichia coli is the major cause of acute renal failure in young children. The interaction of Shiga toxins 1 and 2 (Stx1 and Stx2) with endothelial cells is an important step in the renal coagulation and thrombosis observed in hemolytic uremic syndrome ...
T G, Obrig +6 more
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Click Detect: A Rapid and Sensitive Assay for Shiga Toxin 2 Detection. [PDF]
Biosensors (Basel)Shiga toxin–producing Escherichia coli (STEC) are major foodborne pathogens responsible for severe gastrointestinal disease and hemolytic uremic syndrome (HUS). Here we report Click Detect, a novel diagnostic platform that leverages click display – an in vitro protein display technology – to generate uniform and covalently linked protein–cDNA ...
Thomas BM +4 more
europepmc +4 more sources
Isogenic Lysogens of Diverse Shiga Toxin 2-Encoding Bacteriophages Produce Markedly Different Amounts of Shiga Toxin [PDF]
Infection and Immunity, 1999 ABSTRACT We produced isogenic Escherichia coli K-12 lysogens of seven different Shiga toxin 2 (Stx2)-encoding bacteriophages derived from clinical Shiga toxin-producing E. coli (STEC) isolates of serotypes O157:H7, O145, O111, and O83 to assess the variability among these phages and
P L, Wagner, D W, Acheson, M K, Waldor
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Shiga Toxin-Producing E. coli in Animals: Detection, Characterization, and Virulence Assessment [PDF]
, 2021 Cattle and other ruminants are primary reservoirs for Shiga toxin-producing Escherichia coli (STEC) strains which have a highly variable, but unpredictable, pathogenic potential for humans.
Christian Menge +7 more
core +1 more source
Safety and Pharmacokinetics of Chimeric Anti-Shiga Toxin 1 and Anti-Shiga Toxin 2 Monoclonal Antibodies in Healthy Volunteers [PDF]
Antimicrobial Agents and Chemotherapy, 2009 ABSTRACT Shiga toxin (Stx)-producing Escherichia coli (STEC) causes hemorrhagic colitis and hemolytic-uremic syndrome (HUS). The rates of STEC infection and complications, including death, are highest among young children and elderly individuals. There are no causal therapies.
Martin, Bitzan +6 more
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Shiga toxin 1 is more dependent on the P proteins of the ribosomal stalk for depurination activity than Shiga toxin 2 [PDF]
The International Journal of Biochemistry & Cell Biology, 2011 Shiga toxins produced by Escherichia coli O157:H7 are responsible for food poisoning and hemolytic uremic syndrome (HUS). The A subunits of Shiga toxins (Stx1A and Stx2A) inhibit translation by depurinating a specific adenine in the large rRNA. To determine if Stx1A and Stx2A require the ribosomal stalk for depurination, their activity and cytotoxicity
Jia-Chi, Chiou +4 more
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Structural and Functional Characterization of Stx2k, a New Subtype of Shiga Toxin 2. [PDF]
Microorganisms, 2019 Shiga toxin (Stx) is the major virulence factor of Shiga toxin-producing Escherichia coli (STEC). Stx evolves rapidly and, as such, new subtypes continue to emerge that challenge the efficacy of existing disease management and surveillance strategies. A new subtype, Stx2k, was recently identified in E.
Hughes AC +7 more
europepmc +4 more sources
Chemokine Expression in Human Astrocytes in Response to Shiga Toxin 2 [PDF]
International Journal of Inflammation, 2012 Infection with Shiga toxin- (Stx-) producingEscherichia colican lead to hemolytic uremic syndrome (HUS). Approximately, 30% of patients with HUS suffer from complications in the central nervous system (CNS), which is an important determinant of mortality in such patients.
Naomi Kioka +3 more
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Subtyping of Shiga toxin 2 variants in human-derived Shiga toxin-producingEscherichia colistrains isolated in Japan [PDF]
FEMS Immunology & Medical Microbiology, 2002 Shiga toxin 2 (Stx2) variants have been found to exhibit not only antigenic divergence, but also differences in toxicity for tissue culture cells and animals. To clarify whether all or just a subset of Stx2 variants are important for the virulence of Shiga toxin-producing Escherichia coli, we designed PCR primers to detect and type all reported ...
Hiroshi, Nakao +4 more
openaire +3 more sources