Results 21 to 30 of about 123,037 (250)

Hemolytic Uremic Syndrome Outbreak in Adults and Shiga Toxin–Producing Escherichia coli Negative for Locus of Enterocyte Effacement, France, 2025 [PDF]

Emerging Infectious Diseases
In January 2025, the Escherichia coli National Reference Center of France detected an outbreak of hemolytic uremic syndrome (HUS) in adults, caused by Shiga toxin–producing E. coli negative for locus of enterocyte effacement (LEE). The outbreak included
Justine de Larminat, Kevin La, Philippe Bidet, André Birgy, Sandrine Liguori, Pierre Phlipaux, Celine Courroux, Florence Crombé, Jorge Blanco, Paul Coppo, Antoine Dossier, Laurence Armand-Lefevre, François Xavier Weill, Carolina Silva Nodari, Gabrielle Jones, Aurelie Cointe, Stéphane Bonacorsi   +16 more
doaj   +2 more sources

Geldanamycin Enhances Retrograde Transport of Shiga Toxin in HEp-2 Cells.

PLoS ONE, 2015
The heat shock protein 90 (Hsp90) inhibitor geldanamycin (GA) has been shown to alter endosomal sorting, diverting cargo destined for the recycling pathway into the lysosomal pathway. Here we investigated whether GA also affects the sorting of cargo into
Anne Berit Dyve Lingelem, Ieva Ailte Hjelseth, Roger Simm, Maria Lyngaas Torgersen, Kirsten Sandvig   +4 more
doaj   +4 more sources

Shiga Toxin/Lipopolysaccharide Activates Caspase-4 and Gasdermin D to Trigger Mitochondrial Reactive Oxygen Species Upstream of the NLRP3 Inflammasome

Cell Reports, 2018
Summary: The non-canonical caspase-4 and canonical NLRP3 inflammasomes are both activated by intracellular lipopolysaccharide (LPS), but the crosstalk between these two pathways remains unclear.
Hyunjae Chung, Arthur Lau, Christina F Sandall   +2 more
exaly   +3 more sources

Baicalin Protects Mice from Lethal Infection by Enterohemorrhagic Escherichia coli [PDF]

Frontiers in Microbiology, 2017
Shiga-like toxin-producing Escherichia coli (STEC) O157:H7 poses grave challenges to public health by its ability to cause severe colonic diseases and renal failure in both human and animals.
Yong Zhang, Yong Zhang, Zhimin Qi, Zhimin Qi, Yan Liu, Yan Liu, Wenqi He, Cheng Yang, Quan Wang, Jing Dong, Xuming Deng, Xuming Deng   +11 more
doaj   +2 more sources

High-fat and high-carbohydrate diets worsen the mouse brain susceptibility to damage produced by enterohemorrhagic Escherichia coli Shiga toxin 2 [PDF]

Heliyon
Background: Nutrition quality could be one of the reasons why, in the face of a Shiga toxin-producing enterohemorrhagic Escherichia coli outbreak, some patients experience more profound deleterious effects than others, including unfortunate deaths. Thus,
D. Arenas-Mosquera, N. Cerny, A. Cangelosi, P.A. Geoghegan, E.L. Malchiodi, M. De Marzi, A. Pinto, J. Goldstein   +7 more
doaj   +2 more sources

A Novel Shiga Toxin 1a-Converting Bacteriophage of Shigella sonnei With Close Relationship to Shiga Toxin 2-Converting Pages of Escherichia coli [PDF]

Open Forum Infectious Diseases, 2016
In recent studies, strains of non-dysenteriae 1 Shigella (NDS) expressing Shiga toxin have been reported. In this study, we report a novel stx1a-converting bacteriophage of Shigella sonnei associated with travel to Mexico. Phylogenetic comparison between
C. Carter, J. Fierer, W. Chiu, D. Looney, M. Strain, S. Mehta   +5 more
semanticscholar   +5 more sources

Isothermal Amplification and Lateral Flow Nucleic Acid Test for the Detection of Shiga Toxin-Producing Bacteria for Food Monitoring

Chemosensors, 2022
Foodborne bacteria have persisted as a significant threat to public health and to the food and agriculture industry. Due to the widespread impact of these pathogens, there has been a push for the development of strategies that can rapidly detect ...
Sabrina Petrucci, Emre Dikici, Sylvia Daunert, Sapna K. Deo   +3 more
doaj   +1 more source

Shiga Toxin 2–Specific but Not Shiga Toxin 1–Specific Human Monoclonal Antibody Protects Piglets Challenged with EnterohemorrhagicEscherichia coliProducing Shiga Toxin 1 and Shiga Toxin 2 [PDF]

The Journal of Infectious Diseases, 2010
Escherichia coli strains that produce Shiga toxin 2 (Stx2) are isolated from hemolytic-uremic syndrome (HUS) cases more frequently than are strains that produce both Shiga toxin 1 (Stx1) and Stx2, whereas strains that produce only Stx1 are rarely isolated from HUS cases.
Kwang-Il, Jeong, Saul, Tzipori, Abhineet S, Sheoran   +2 more
openaire   +2 more sources

Tamoxifen Derivatives Alter Retromer-Dependent Endosomal Tubulation and Sorting to Block Retrograde Trafficking of Shiga Toxins

Toxins, 2021
Shiga toxin 1 and 2 (STx1 and STx2) undergo retrograde trafficking to reach the cytosol of cells where they target ribosomes. As retrograde trafficking is essential for disease, inhibiting STx1/STx2 trafficking is therapeutically promising.
Andrey S. Selyunin, Karinel Nieves-Merced, Danyang Li, Stanton F. McHardy, Somshuvra Mukhopadhyay   +4 more
doaj   +1 more source

Induction by Sphingomyelinase of Shiga Toxin Receptor and Shiga Toxin 2 Sensitivity in Human Microvascular Endothelial Cells [PDF]

Infection and Immunity, 2003
ABSTRACT Shiga toxin-producing enterohemorrhagic Escherichia coli is the major cause of acute renal failure in young children. The interaction of Shiga toxins 1 and 2 (Stx1 and Stx2) with endothelial cells is an important step in the renal coagulation and thrombosis observed in hemolytic uremic syndrome ...
T G, Obrig, R M, Seaner, M, Bentz, C A, Lingwood, B, Boyd, A, Smith, W, Narrow   +6 more
openaire   +2 more sources