Results 181 to 190 of about 24,858 (221)
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Annual Review of Plant Physiology and Plant Molecular Biology, 1999
▪ Abstract The shikimate pathway links metabolism of carbohydrates to biosynthesis of aromatic compounds. In a sequence of seven metabolic steps, phosphoenolpyruvate and erythrose 4-phosphate are converted to chorismate, the precursor of the aromatic amino acids and many aromatic secondary metabolites.
Klaus M., Herrmann, Lisa M., Weaver
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▪ Abstract The shikimate pathway links metabolism of carbohydrates to biosynthesis of aromatic compounds. In a sequence of seven metabolic steps, phosphoenolpyruvate and erythrose 4-phosphate are converted to chorismate, the precursor of the aromatic amino acids and many aromatic secondary metabolites.
Klaus M., Herrmann, Lisa M., Weaver
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Microbial engineering for shikimate biosynthesis
Enzyme and Microbial Technology, 2023Shikimate, a precursor to the antiviral drug oseltamivir (Tamiflu®), can influence aromatic metabolites and finds extensive use in antimicrobial, antitumor, and cardiovascular applications. Consequently, various strategies have been developed for chemical synthesis and plant extraction to enhance shikimate biosynthesis, potentially impacting ...
Qiang, Ding, Chao, Ye
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Biotechnology Advances, 2012
Shikimic acid is a key intermediate for the synthesis of the antiviral drug oseltamivir (Tamiflu®). Shikimic acid can be produced via chemical synthesis, microbial fermentation and extraction from certain plants. An alternative production route is via biotransformation of the more readily available quinic acid.
Saptarshi, Ghosh +2 more
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Shikimic acid is a key intermediate for the synthesis of the antiviral drug oseltamivir (Tamiflu®). Shikimic acid can be produced via chemical synthesis, microbial fermentation and extraction from certain plants. An alternative production route is via biotransformation of the more readily available quinic acid.
Saptarshi, Ghosh +2 more
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China Journal of Chinese Materia Medica, 2016
This study was performed to systematically investigate the polymorphism of shikimic acid. Through optimizing the recrystallization solvent, solvent volume, recrystallization temperature, time and pressure, three crystal forms were discovered and prepared.
Feng-Feng, Wang, De-Zhi, Yang, Yang, Lv
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This study was performed to systematically investigate the polymorphism of shikimic acid. Through optimizing the recrystallization solvent, solvent volume, recrystallization temperature, time and pressure, three crystal forms were discovered and prepared.
Feng-Feng, Wang, De-Zhi, Yang, Yang, Lv
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The Biosynthesis of Shikimate Metabolites
ChemInform, 1999AbstractFor Abstract see ChemInform Abstract in Full Text.
Andrew R. Knaggs +2 more
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Enantiospecific synthesis of (−)-5-epi-shikimic acid and (−)-shikimic acid
Journal of the Chemical Society, Perkin Transactions 1, 1997Diastereoselective reaction of 2,3-O-isopropylidene-D-ribose with allylmagnesium chloride gave a 5∶1 mixture of triols 4 and 5, which were then converted to nitrones 8 and 9. Intramolecular nitrone cycloaddition gave the isoxazolidines 10 and 11, which on acetylation gave the corresponding acetates 12 and 13 which were separated by repeated ...
Shende Jiang +4 more
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Interaction of shikimic acid with shikimate kinase.
Biochemical and biophysical research communications, 2005The crystal structure of shikimate kinase from Mycobacterium tuberculosis (MtSK) complexed with MgADP and shikimic acid (shikimate) has been determined at 2.3A resolution, clearly revealing the amino acid residues involved in shikimate binding. In MtSK, the Glu61 strictly conserved in SK forms a hydrogen bond and salt-bridge with Arg58 and assists in ...
José Henrique, Pereira +7 more
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ACS Synthetic Biology, 2017
The quantitative monitoring of intracellular metabolites with in vivo biosensors provides an efficient means of identifying high-yield strains and observing product accumulation in real time. In this study, a shikimic acid (SA) biosensor was constructed from a LysR-type transcriptional regulator (ShiR) of Corynebacterium glutamicum.
Chang Liu +4 more
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The quantitative monitoring of intracellular metabolites with in vivo biosensors provides an efficient means of identifying high-yield strains and observing product accumulation in real time. In this study, a shikimic acid (SA) biosensor was constructed from a LysR-type transcriptional regulator (ShiR) of Corynebacterium glutamicum.
Chang Liu +4 more
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