Results 171 to 180 of about 15,124 (230)
Menaquinone depletion resensitises bedaquiline-resistant tuberculosis
Wetzel J +44 more
europepmc +1 more source
Rerouting of the lignin biosynthetic pathway by inhibition of cytosolic shikimate recycling in transgenic hybrid aspen [PDF]
Plant Journal, 2022 Lignin is a phenolic polymer deposited in the plant cell wall and is mainly polymerized from three canonical monomers (monolignols), i.e., p-coumaryl, coniferyl, and sinapyl alcohols.
Nobutaka Mitsuda +2 more
exaly +2 more sources
Effects of the magnesium and chloride ions and shikimate on the structure of shikimate kinase fromMycobacterium tuberculosis [PDF]
Acta Crystallographica Section F: Structural Biology Communications, 2007 Bacteria, fungi and plants can convert carbohydrate and phosphoenolpyruvate into chorismate, which is the precursor of various aromatic compounds. The seven enzymes of the shikimate pathway are responsible for this conversion.
Walter F DE AZEVEDO +2 more
exaly +3 more sources
Transport of the antibacterial agent (6S)-6-fluoroshikimate and other shikimate analogues by the shikimate transport system of Escherichia coli [PDF]
Biochimica Et Biophysica Acta - Biomembranes, 1996 We show that the antibacterial agent, (6S)-6-fluoroshikimate, is a substrate for the shikimate transport system of Escherichia coli because in exchange-diffusion experiments it displaced intracellular [14C]shikimate with the same kinetics as did ...
Gareth M Davies
exaly +2 more sources
Crystallographic studies of shikimate binding and induced conformational changes inMycobacterium tuberculosisshikimate kinase [PDF]
FEBS Letters, 2004 The X-ray crystal structure of Mycobacterium tuberculosis shikimate kinase (SK) with bound shikimate and adenosine diphosphate (ADP) has been determined to a resolution of 2.15 A.
Balvinder Dhaliwal, Jingshan Ren
exaly +2 more sources
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Microbial engineering for shikimate biosynthesis
Enzyme and Microbial Technology, 2023Shikimate, a precursor to the antiviral drug oseltamivir (Tamiflu®), can influence aromatic metabolites and finds extensive use in antimicrobial, antitumor, and cardiovascular applications. Consequently, various strategies have been developed for chemical synthesis and plant extraction to enhance shikimate biosynthesis, potentially impacting ...
Qiang, Ding, Chao, Ye
openaire +2 more sources
Annual Review of Plant Physiology and Plant Molecular Biology, 1999
▪ Abstract The shikimate pathway links metabolism of carbohydrates to biosynthesis of aromatic compounds. In a sequence of seven metabolic steps, phosphoenolpyruvate and erythrose 4-phosphate are converted to chorismate, the precursor of the aromatic amino acids and many aromatic secondary metabolites.
Klaus M., Herrmann, Lisa M., Weaver
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▪ Abstract The shikimate pathway links metabolism of carbohydrates to biosynthesis of aromatic compounds. In a sequence of seven metabolic steps, phosphoenolpyruvate and erythrose 4-phosphate are converted to chorismate, the precursor of the aromatic amino acids and many aromatic secondary metabolites.
Klaus M., Herrmann, Lisa M., Weaver
openaire +2 more sources
The Biosynthesis of Shikimate Metabolites
ChemInform, 1999AbstractFor Abstract see ChemInform Abstract in Full Text.
Andrew R. Knaggs +2 more
openaire +5 more sources
China Journal of Chinese Materia Medica, 2016
This study was performed to systematically investigate the polymorphism of shikimic acid. Through optimizing the recrystallization solvent, solvent volume, recrystallization temperature, time and pressure, three crystal forms were discovered and prepared.
Feng-Feng, Wang, De-Zhi, Yang, Yang, Lv
openaire +2 more sources
This study was performed to systematically investigate the polymorphism of shikimic acid. Through optimizing the recrystallization solvent, solvent volume, recrystallization temperature, time and pressure, three crystal forms were discovered and prepared.
Feng-Feng, Wang, De-Zhi, Yang, Yang, Lv
openaire +2 more sources
Biotechnology Advances, 2012
Shikimic acid is a key intermediate for the synthesis of the antiviral drug oseltamivir (Tamiflu®). Shikimic acid can be produced via chemical synthesis, microbial fermentation and extraction from certain plants. An alternative production route is via biotransformation of the more readily available quinic acid.
Saptarshi, Ghosh +2 more
openaire +2 more sources
Shikimic acid is a key intermediate for the synthesis of the antiviral drug oseltamivir (Tamiflu®). Shikimic acid can be produced via chemical synthesis, microbial fermentation and extraction from certain plants. An alternative production route is via biotransformation of the more readily available quinic acid.
Saptarshi, Ghosh +2 more
openaire +2 more sources