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Shikimic Acid Pathway Metabolites
1981Benzenoid compounds in plants are biosynthesised by two main pathways: the shikimic acid pathway and the acetate-malonate pathway (Chapter 4). In higher plants, a large number of aromatic compounds are derived from phenylalanine, tyrosine and tryptophan, end-products of the shikimic acid pathway.
Margaret L. Vickery, Brian Vickery
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Fluorine-containing analogs of intermediates in the shikimate pathway
Biochemistry, 1976The phosphoenolpyruvate analogue (Z)-phosphoenol-3-fluoropyruvate is a substrate for phenylalanine-inhibitable 3-deoxy-D-arabino-heptulosonic acid-7-phosphate synthase from Escherichia coli. In the presence of excess erythrose 4-phosphate, apparent KM values of 65 and 38 muM were observed for phosphoenol-3-fluoropyruvate and phosphoenolpyruvate ...
P F, Pilch, R L, Somerville
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Annotating the Plasmodium genome and the enigma of the shikimate pathway
Trends in Parasitology, 2004The completion of the Plasmodium falciparum genome sequence heralds a new era in the effort to identify all the parasite's genes along with their cellular functions. A combination of bioinformatics and experimental proof will facilitate this process.
McConkey, G.A. +6 more
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The shikimate pathway. Part 9. Halogenation at C-3 of the shikimate nucleus
Tetrahedron, 1996Abstract The use of (−)-shikimic acid as starting material in the syntheses of a series of C-3 halogenated derivatives including the analogous 3α- and 3β-fluoro and 3β-chloro acids is described together with the first stereospecific synthesis of (−)-3-epi-shikimic acid directly from the parent acid.
Roger Brettle +5 more
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The Shikimate Pathway’s First Enzyme
1991The shikimate pathway, a major route of carbon metabolism, leads to the biosynthesis of the three aromatic amino acids phenylalanine, tyrosine, and tryptophan (Herrmann, 1983; Pittard, 1987). In some plants, more than 20% of the fixed carbon flows through this pathway, the bulk for biosynthesis of secondary metabolites such as lignins, phytoalexins ...
Klaus M. Herrmann +3 more
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Mycobacterial Shikimate Pathway Enzymes as Targets for Drug Design
Current Drug Targets, 2007The aetiological agent of tuberculosis (TB), Mycobacterium tuberculosis, is responsible for millions of deaths annually. The increasing prevalence of the disease, the emergence of multidrug-resistant strains, and the devastating effect of human immunodeficiency virus co-infection have led to an urgent need for the development of new and more efficient ...
R G, Ducati, L A, Basso, D S, Santos
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The Shikimate Pathway: Biosynthesis of Phenolic Products from Shikimic Acid
2016Like other amino acids, the aromatic amino acids phenylalanine, tyrosine, and tryptophan are vitally important for protein synthesis in all organisms. However, while animals can synthesize tyrosine via oxidation of phenylalanine, they can synthesize neither phenylalanine itself nor tryptophan and so these essential amino acids must be obtained in the ...
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Aspects of the Enzymology of the Shikimate Pathway
1996These are the concluding words of an appreciation of the life and scientific work of Johan Frederik Eykman (1851–1915) published in Recueil Travaux Chimique des Pays-Bas, XXXV, 365–420 (1916), written by A. F.Holleman. It is very doubtful if the writer appreciated, at the time, the full significance of his words.
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