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Evidence for the shikimate pathway in apicomplexan parasites

Nature, 1998
Parasites of the phylum Apicomplexa cause substantial morbidity, mortality and economic losses, and new medicines to treat them are needed urgently. The shikimate pathway is an attractive target for herbicides and antimicrobial agents because it is essential in algae, higher plants, bacteria and fungi, but absent from mammals.
Roberts, F   +11 more
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Shikimic Acid Pathway

2014
Of the identified biosynthetic paths, shikimic acid pathway plays a very important role in providing precursors of a large number of aromatic compounds of diverse skeletal patterns and substitutions. Chorismic acid, an important branching point product in the shikimic acid pathway also serves as an important precursor. Natural products with C 6 –C 1 or
Sunil Kumar Talapatra, Bani Talapatra
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Dynamics of the shikimate pathway in plants

Trends in Plant Science, 1997
The shikimate pathway, a collection of seven enzymatic reactions whose end product is chorismate, has been studied for many years in a variety of microorganisms and plants. In microbial systems, the end product of the pathway is used primarily for the synthesis of aromatic amino acids.
Lisa M. Weaver, Klaus M. Herrmann
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Shikimic Acid Pathway: Phenols

2023
Plant metabolites having one or more hydroxyl groups attached to an aromatic ring are known as phenols. Phenols are a heterogeneous group of compounds. One of the most important functions of phenols is in plant communication e.g., allelopathy, attracting pollinating and disseminating agents, attracting symbiotic bacteria, and inhibiting pathogens and ...
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The Shikimate Pathway

1979
The shikimate pathway is the major metabolic route leading to the formation of aromatic compounds in living systems. It operates in microorganisms and in higher plants, but not in animals, which is why the latter are dependent on a dietary supply of the aromatic amino acids phenylalanine, tyrosine and tryptophan.
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The shikimic acid pathway

1981
A compound of unsuspected importance was isolated in 1885 from the fruit of Illicium religiosum. To this compound was given the name shikimic acid, a name derived from shikimi-no-ki which is the Japanese name for the plant. Shikimic acid (5.7), it transpired from the very elegant studies of much later investigators, is a key intermediate in the ...
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Shikimic Acid Pathway

1998
Most aromatic compounds in plants are derived from shikimic acid metabolism; many of these substances are phenols. Compounds derived from this pathway are extensively modified and considered under other classes of plant secondary metabolites. Although many types of secondary compounds are produced from intermediates of the shikimic acid pathway (e.g ...
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The Shikimate Pathway — An Overview

1986
It has been eight years since the Phytochemical Society last held a symposium centered on the theme of Biosynthesis of Aromatic Compounds at its joint meeting with the European Phytochemical Society in Ghent.1 The intervening years have seen a tremendous revival of interest in the shikimate pathway. This renewed focus was stimulated by the discovery in
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The Shikimate Pathway — A Metabolic Tree with Many Branche

Critical Reviews in Biochemistry and Molecular Biology, 1990
(1990). The Shikimate Pathway — A Metabolic Tree with Many Branche. Critical Reviews in Biochemistry and Molecular Biology: Vol. 25, No. 5, pp. 307-384.
Ronald Bentley, E. Haslam
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The Shikimic Acid Pathway

1986
1. Early Research on the Shikimate Pathway: Some Personal Remarks and Reminiscences.- 2. The Shikimate Pathway - An Overview.- 3. Tyrosine and Phenylalanine Biosynthesis: Relationship Between Alternative Pathways, Regulation and Subcellular Location.- 4.
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