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Shikimic Acid Pathway: Phenols
2023Plant metabolites having one or more hydroxyl groups attached to an aromatic ring are known as phenols. Phenols are a heterogeneous group of compounds. One of the most important functions of phenols is in plant communication e.g., allelopathy, attracting pollinating and disseminating agents, attracting symbiotic bacteria, and inhibiting pathogens and ...
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Shikimic Acid Pathway Metabolites
1981Benzenoid compounds in plants are biosynthesised by two main pathways: the shikimic acid pathway and the acetate-malonate pathway (Chapter 4). In higher plants, a large number of aromatic compounds are derived from phenylalanine, tyrosine and tryptophan, end-products of the shikimic acid pathway.
Margaret L. Vickery, Brian Vickery
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Biosynthesis of Diverse Class Flavonoids via Shikimate and Phenylpropanoid Pathway
, 2021Flavonoids are natural products, which are useful in the protection of various types of human diseases. Several bioactive flavonoids as chalcones, flavonols, flavanol, flavones, flavanone, flavan, isoflavonoids, and proanthocyanidin, are found in parts ...
M. Rehan
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Evidence for the shikimate pathway in apicomplexan parasites
Nature, 1998Parasites of the phylum Apicomplexa cause substantial morbidity, mortality and economic losses, and new medicines to treat them are needed urgently. The shikimate pathway is an attractive target for herbicides and antimicrobial agents because it is essential in algae, higher plants, bacteria and fungi, but absent from mammals.
Roberts, F +11 more
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New tuberculosis drug development: targeting the shikimate pathway
Expert Opinion on Drug Discovery, 2008Tuberculosis (TB) remains a leading cause of morbidity and mortality worldwide, yet no new drugs have been developed in the last 40 years.The exceedingly lengthy TB chemotherapy and the increasing emergence of drug resistance complicated by HIV co-infection call for the development of new TB drugs.
Senta M, Kapnick, Ying, Zhang
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Dynamics of the shikimate pathway in plants
Trends in Plant Science, 1997The shikimate pathway, a collection of seven enzymatic reactions whose end product is chorismate, has been studied for many years in a variety of microorganisms and plants. In microbial systems, the end product of the pathway is used primarily for the synthesis of aromatic amino acids.
Lisa M. Weaver, Klaus M. Herrmann
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The Shikimate Pathway’s First Enzyme
1991The shikimate pathway, a major route of carbon metabolism, leads to the biosynthesis of the three aromatic amino acids phenylalanine, tyrosine, and tryptophan (Herrmann, 1983; Pittard, 1987). In some plants, more than 20% of the fixed carbon flows through this pathway, the bulk for biosynthesis of secondary metabolites such as lignins, phytoalexins ...
Klaus M. Herrmann +3 more
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Biotechnology Journal, 2019
3-Phenyllactic acid (PhLA) is useful as a start-up material in the pharmaceutical and biorefinery industries. To enhance the production of PhLA from glucose using recombinant Escherichia coli, the effects of glucose concentration and oxygen limitation on
H. Kawaguchi +5 more
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3-Phenyllactic acid (PhLA) is useful as a start-up material in the pharmaceutical and biorefinery industries. To enhance the production of PhLA from glucose using recombinant Escherichia coli, the effects of glucose concentration and oxygen limitation on
H. Kawaguchi +5 more
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1998
Most aromatic compounds in plants are derived from shikimic acid metabolism; many of these substances are phenols. Compounds derived from this pathway are extensively modified and considered under other classes of plant secondary metabolites. Although many types of secondary compounds are produced from intermediates of the shikimic acid pathway (e.g ...
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Most aromatic compounds in plants are derived from shikimic acid metabolism; many of these substances are phenols. Compounds derived from this pathway are extensively modified and considered under other classes of plant secondary metabolites. Although many types of secondary compounds are produced from intermediates of the shikimic acid pathway (e.g ...
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Molecular models for shikimate pathway enzymes of Xylella fastidiosa
Biochemical and Biophysical Research Communications, 2004The Xylella fastidiosa is a bacterium that is the cause of citrus variegated chlorosis (CVC). The shikimate pathway is of pivotal importance for production of a plethora of aromatic compounds in plants, bacteria, and fungi. Putative structural differences in the enzymes from the shikimate pathway, between the proteins of bacterial origin and those of ...
Arcuri, H. A. +9 more
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