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1979
The shikimate pathway is the major metabolic route leading to the formation of aromatic compounds in living systems. It operates in microorganisms and in higher plants, but not in animals, which is why the latter are dependent on a dietary supply of the aromatic amino acids phenylalanine, tyrosine and tryptophan.
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The shikimate pathway is the major metabolic route leading to the formation of aromatic compounds in living systems. It operates in microorganisms and in higher plants, but not in animals, which is why the latter are dependent on a dietary supply of the aromatic amino acids phenylalanine, tyrosine and tryptophan.
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Mycobacterial Shikimate Pathway Enzymes as Targets for Drug Design
Current Drug Targets, 2007The aetiological agent of tuberculosis (TB), Mycobacterium tuberculosis, is responsible for millions of deaths annually. The increasing prevalence of the disease, the emergence of multidrug-resistant strains, and the devastating effect of human immunodeficiency virus co-infection have led to an urgent need for the development of new and more efficient ...
R G, Ducati, L A, Basso, D S, Santos
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The Shikimate Pathway — A Metabolic Tree with Many Branche
Critical Reviews in Biochemistry and Molecular Biology, 1990(1990). The Shikimate Pathway — A Metabolic Tree with Many Branche. Critical Reviews in Biochemistry and Molecular Biology: Vol. 25, No. 5, pp. 307-384.
Ronald Bentley, E. Haslam
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1986
1. Early Research on the Shikimate Pathway: Some Personal Remarks and Reminiscences.- 2. The Shikimate Pathway - An Overview.- 3. Tyrosine and Phenylalanine Biosynthesis: Relationship Between Alternative Pathways, Regulation and Subcellular Location.- 4.
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1. Early Research on the Shikimate Pathway: Some Personal Remarks and Reminiscences.- 2. The Shikimate Pathway - An Overview.- 3. Tyrosine and Phenylalanine Biosynthesis: Relationship Between Alternative Pathways, Regulation and Subcellular Location.- 4.
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Fluorine-containing analogs of intermediates in the shikimate pathway
Biochemistry, 1976The phosphoenolpyruvate analogue (Z)-phosphoenol-3-fluoropyruvate is a substrate for phenylalanine-inhibitable 3-deoxy-D-arabino-heptulosonic acid-7-phosphate synthase from Escherichia coli. In the presence of excess erythrose 4-phosphate, apparent KM values of 65 and 38 muM were observed for phosphoenol-3-fluoropyruvate and phosphoenolpyruvate ...
P F, Pilch, R L, Somerville
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Revisiting the shikimate pathway and highlighting their enzyme inhibitors
Phytochemistry Reviews, 2023Aline Marengoni Almeida +5 more
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The shikimate pathway. Part 9. Halogenation at C-3 of the shikimate nucleus
Tetrahedron, 1996Abstract The use of (−)-shikimic acid as starting material in the syntheses of a series of C-3 halogenated derivatives including the analogous 3α- and 3β-fluoro and 3β-chloro acids is described together with the first stereospecific synthesis of (−)-3-epi-shikimic acid directly from the parent acid.
Roger Brettle +5 more
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1981
A compound of unsuspected importance was isolated in 1885 from the fruit of Illicium religiosum. To this compound was given the name shikimic acid, a name derived from shikimi-no-ki which is the Japanese name for the plant. Shikimic acid (5.7), it transpired from the very elegant studies of much later investigators, is a key intermediate in the ...
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A compound of unsuspected importance was isolated in 1885 from the fruit of Illicium religiosum. To this compound was given the name shikimic acid, a name derived from shikimi-no-ki which is the Japanese name for the plant. Shikimic acid (5.7), it transpired from the very elegant studies of much later investigators, is a key intermediate in the ...
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The Shikimate Pathway — An Overview
1986It has been eight years since the Phytochemical Society last held a symposium centered on the theme of Biosynthesis of Aromatic Compounds at its joint meeting with the European Phytochemical Society in Ghent.1 The intervening years have seen a tremendous revival of interest in the shikimate pathway. This renewed focus was stimulated by the discovery in
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