Results 181 to 190 of about 12,511 (215)
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1981
A compound of unsuspected importance was isolated in 1885 from the fruit of Illicium religiosum. To this compound was given the name shikimic acid, a name derived from shikimi-no-ki which is the Japanese name for the plant. Shikimic acid (5.7), it transpired from the very elegant studies of much later investigators, is a key intermediate in the ...
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A compound of unsuspected importance was isolated in 1885 from the fruit of Illicium religiosum. To this compound was given the name shikimic acid, a name derived from shikimi-no-ki which is the Japanese name for the plant. Shikimic acid (5.7), it transpired from the very elegant studies of much later investigators, is a key intermediate in the ...
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1986
1. Early Research on the Shikimate Pathway: Some Personal Remarks and Reminiscences.- 2. The Shikimate Pathway - An Overview.- 3. Tyrosine and Phenylalanine Biosynthesis: Relationship Between Alternative Pathways, Regulation and Subcellular Location.- 4.
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1. Early Research on the Shikimate Pathway: Some Personal Remarks and Reminiscences.- 2. The Shikimate Pathway - An Overview.- 3. Tyrosine and Phenylalanine Biosynthesis: Relationship Between Alternative Pathways, Regulation and Subcellular Location.- 4.
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The shikimate pathway. Part 9. Halogenation at C-3 of the shikimate nucleus
Tetrahedron, 1996Abstract The use of (−)-shikimic acid as starting material in the syntheses of a series of C-3 halogenated derivatives including the analogous 3α- and 3β-fluoro and 3β-chloro acids is described together with the first stereospecific synthesis of (−)-3-epi-shikimic acid directly from the parent acid.
Roger Brettle +5 more
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1998
Most aromatic compounds in plants are derived from shikimic acid metabolism; many of these substances are phenols. Compounds derived from this pathway are extensively modified and considered under other classes of plant secondary metabolites. Although many types of secondary compounds are produced from intermediates of the shikimic acid pathway (e.g ...
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Most aromatic compounds in plants are derived from shikimic acid metabolism; many of these substances are phenols. Compounds derived from this pathway are extensively modified and considered under other classes of plant secondary metabolites. Although many types of secondary compounds are produced from intermediates of the shikimic acid pathway (e.g ...
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The Shikimate Pathway — An Overview
1986It has been eight years since the Phytochemical Society last held a symposium centered on the theme of Biosynthesis of Aromatic Compounds at its joint meeting with the European Phytochemical Society in Ghent.1 The intervening years have seen a tremendous revival of interest in the shikimate pathway. This renewed focus was stimulated by the discovery in
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The Shikimate Pathway’s First Enzyme
1991The shikimate pathway, a major route of carbon metabolism, leads to the biosynthesis of the three aromatic amino acids phenylalanine, tyrosine, and tryptophan (Herrmann, 1983; Pittard, 1987). In some plants, more than 20% of the fixed carbon flows through this pathway, the bulk for biosynthesis of secondary metabolites such as lignins, phytoalexins ...
Klaus M. Herrmann +3 more
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Mycobacterial Shikimate Pathway Enzymes as Targets for Drug Design
Current Drug Targets, 2007The aetiological agent of tuberculosis (TB), Mycobacterium tuberculosis, is responsible for millions of deaths annually. The increasing prevalence of the disease, the emergence of multidrug-resistant strains, and the devastating effect of human immunodeficiency virus co-infection have led to an urgent need for the development of new and more efficient ...
R G, Ducati, L A, Basso, D S, Santos
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New tuberculosis drug development: targeting the shikimate pathway
Expert Opinion on Drug Discovery, 2008Tuberculosis (TB) remains a leading cause of morbidity and mortality worldwide, yet no new drugs have been developed in the last 40 years.The exceedingly lengthy TB chemotherapy and the increasing emergence of drug resistance complicated by HIV co-infection call for the development of new TB drugs.
Senta M, Kapnick, Ying, Zhang
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Shikimate and folate pathways in the protozoan parasite, Perkinsus olseni
Molecular and Biochemical Parasitology, 2005We have exploited the experimental accessibility of the protozoan parasite Perkinsus olseni and its similarities to apicomplexan parasites to investigate the influence of specific drugs on its proliferation. For this purpose, shikimate and folate pathways present an attractive target for parasitic therapy given their major differences with mammalian ...
Elandalloussi, Laurence M. +5 more
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