Results 31 to 40 of about 2,926,592 (211)

Identification of polyketide inhibitors targeting 3-dehydroquinate dehydratase in the shikimate pathway of Enterococcus faecalis. [PDF]

PLoS ONE, 2014
Due to the emergence of resistance toward current antibiotics, there is a pressing need to develop the next generation of antibiotics as therapeutics against infectious and opportunistic diseases of microbial origins.
Vivian Wing Ngar Cheung, Bo Xue, Maria Hernandez-Valladares, Maybelle Kho Go, Alvin Tung, Adeleke H Aguda, Robert C Robinson, Wen Shan Yew   +7 more
doaj   +1 more source

Targeting hydroxycinnamoyl CoA: shikimate hydroxycinnamoyl transferase for lignin modification in Brachypodium distachyon

Biotechnology for Biofuels, 2021
Background Hydroxycinnamoyl CoA: shikimate hydroxycinnamoyl transferase (HCT) is a central enzyme of the so-called “esters” pathway to monolignols. As originally envisioned, HCT functions twice in this pathway, to form coumaroyl shikimate and then, in ...
Juan Carlos Serrani-Yarce, Luis Escamilla-Trevino, Jaime Barros, Lina Gallego-Giraldo, Yunqiao Pu, Art Ragauskas, Richard A. Dixon   +6 more
doaj   +1 more source

EPSP Synthase-Depleted Cells Are Aromatic Amino Acid Auxotrophs in Mycobacterium smegmatis

Microbiology Spectrum, 2021
The epidemiological importance of mycobacterial species is indisputable, and the necessity to find new molecules that can inhibit their growth is urgent.
Mario Alejandro Duque-Villegas, Bruno Lopes Abbadi, Paulo Ricardo Romero, Letícia Beatriz Matter, Luiza Galina, Pedro Ferrari Dalberto, Valnês da Silva Rodrigues-Junior, Rodrigo Gay Ducati, Candida Deves Roth, Raoní Scheibler Rambo, Eduardo Vieira de Souza, Marcia Alberton Perello, Héctor Ricardo Morbidoni, Pablo Machado, Luiz Augusto Basso, Cristiano Valim Bizarro   +15 more
doaj   +1 more source

Novel technologies combined with traditional metabolic engineering strategies facilitate the construction of shikimate-producing Escherichia coli

Microbial Cell Factories, 2017
Shikimate is an important intermediate in the aromatic amino acid pathway, which can be used as a promising building block for the synthesis of biological compounds, such as neuraminidase inhibitor Oseltamivir (Tamiflu®).
Pengfei Gu, Xiangyu Fan, Quanfeng Liang, Qingsheng Qi, Qiang Li   +4 more
doaj   +1 more source

Xylose and shikimate transporters facilitates microbial consortium as a chassis for benzylisoquinoline alkaloid production

Nature Communications, 2023
Plant-sourced aromatic amino acid (AAA) derivatives are a vast group of compounds with broad applications. Here, we present the development of a yeast consortium for efficient production of (S)-norcoclaurine, the key precursor for benzylisoquinoline ...
Meirong Gao, Yuxin Zhao, Zhanyi Yao, Qianhe Su, Payton Van Beek, Zengyi Shao   +5 more
doaj   +1 more source

Synergetic engineering of Escherichia coli for efficient production of l-tyrosine

Synthetic and Systems Biotechnology, 2023
l-Tyrosine, an aromatic non-essential amino acid, is the raw material for many important chemical products, including levodopa, resveratrol, and hydroxytyrosol. It is widely used in the food, drug, and chemical industries.
Jurong Ping, Lian Wang, Zhijie Qin, Zhemin Zhou, Jingwen Zhou   +4 more
doaj   +1 more source

Shikimate and phenylalanine biosynthesis in the green lineage

Frontiers in Plant Science, 2013
The shikimate pathway provides carbon skeletons for the aromatic amino acids L-tryptophan, L-phenylalanine and L-tyrosine. It is a high flux bearing pathway and it has been estimated that greater than 30% of all fixed carbon is directed through this ...
Takayuki eTohge, Mutsumi eWatanabe, Rainer eHoefgen, Alisdair R Fernie   +3 more
doaj   +1 more source

Deciphering the mechanism of anhydrobiosis in the entomopathogenic nematode Heterorhabditis indica through comparative transcriptomics.

PLoS ONE, 2022
The entomopathogenic nematode, Heterorhabditis indica, is a popular biocontrol agent of high commercial significance. It possesses tremendous genetic architecture to survive desiccation stress by undergoing anhydrobiosis to increase its lifespan-an ...
Manimaran Balakumaran, Parameshwaran Chidambaranathan, Jagannadham Prasanth Tej Kumar J P, Anil Sirohi, Pradeep Kumar Jain, Kishore Gaikwad, Yuvaraj Iyyappan, Atmakuri Ramakrishna Rao, Sarika Sahu, Anil Dahuja, Sharad Mohan   +10 more
doaj   +1 more source

Aniline is an inducer, and not a precursor, for indole derivatives in Rubrivivax benzoatilyticus JA2. [PDF]

PLoS ONE, 2014
Rubrivivax benzoatilyticus JA2 and other anoxygenic photosynthetic bacteria produce indole derivatives when exposed to aniline, a xenobiotic compound. Though this phenomenon has been reported previously, the role of aniline in the production of indoles ...
Mohammed Mujahid, Ch Sasikala, Ch V Ramana   +2 more
doaj   +1 more source

Rerouting of the lignin biosynthetic pathway by inhibition of cytosolic shikimate recycling in transgenic hybrid aspen.

The Plant Journal, 2022
Lignin is a phenolic polymer deposited in the plant cell wall and is mainly polymerized from three canonical monomers (monolignols), i.e., p-coumaryl, coniferyl, and sinapyl alcohols.
Shi Hu, N. Kamimura, Shingo Sakamoto, S. Nagano, Naoki Takata, Sarah Liu, Geert Goeminne, R. Vanholme, Mikiko Uesugi, Masanobu Yamamoto, S. Hishiyama, Hoon Kim, W. Boerjan, J. Ralph, E. Masai, Nobutaka Mitsuda, S. Kajita   +16 more
semanticscholar   +1 more source