Results 91 to 100 of about 1,097,275 (327)

Managing septic shock [PDF]

F1000 Medicine Reports, 2010
Although several successful clinical trials in the last 2-3 years have been greeted with enthusiasm by intensivists, severe sepsis and septic shock still have increasing incidence and more or less unchanged mortality. Within the last few years, the progress in sepsis research covering definitions, epidemiology, pathophysiology, diagnosis, and standard ...
Gerlach, Herwig, Toussaint, Susanne
openaire   +2 more sources

Diastolic shock index and clinical outcomes in patients with septic shock

Annals of Intensive Care, 2020
Background Loss of vascular tone is a key pathophysiological feature of septic shock. Combination of gradual diastolic hypotension and tachycardia could reflect more serious vasodilatory conditions.
G. Ospina-Tascón, J. Teboul, G. Hernández, I. Alvarez, Á. I. Sánchez-Ortiz, L. E. Calderón-Tapia, R. Manzano-Nuñez, Edgardo Quiñones, H. Madriñán-Navia, Juan Esteban Ruiz-Yucuma, J. L. Aldana, J. Bakker   +11 more
semanticscholar   +1 more source

An Ionic Gelation Powder for Ultrafast Hemostasis and Accelerated Wound Healing

Advanced Functional Materials, EarlyView.
An ultrafast ionic gelation‐activated hemostatic powder (AGCL) forms a hydrogel within ≈1 s upon contact with blood‐derived calcium ions. The AGCL powder enables rapid hemorrhage control, strong tissue adhesion, and enhanced healing. The powder's pre‐crosslinked polymer network ensures high blood uptake and stability, offering effective treatment for ...
Youngju Son, Kyusoon Pak, Taehoon Lee, Monica Celine Prayogo, Jinyoung Choi, Sukkyung Kang, Minjoo Kang, Byungkook Oh, Sang Yu Sun, Sanha Kim, Sung Gap Im, Sangyong Jon, Steve Park   +12 more
wiley   +1 more source

Trajectory of Mortality and Health-Related Quality of Life Morbidity Following Community-Acquired Pediatric Septic Shock*

Critical Care Medicine, 2020
Supplemental Digital Content is available in the text. Objectives: In-hospital pediatric sepsis mortality has decreased substantially, but long-term mortality and morbidity among children initially surviving sepsis, is unknown.
Jerry J. Zimmerman, Russell K. Banks, R. Berg, A. Zuppa, C. Newth, D. Wessel, Murray M. Pollack, K. Meert, Mark W. Hall, M. Quasney, A. Sapru, J. Carcillo, P. McQuillen, Peter M. Mourani, H. Wong, Ranjit S Chima, R. Holubkov, Whit Coleman, Samuel Sorenson, J. Varni, Julie McGalliard, W. Haaland, K. Whitlock, J. Dean, R. Reeder   +24 more
semanticscholar   +1 more source

All‐Aqueous Pullulan Fibers Enabling Visible‐to‐Near‐Infrared Waveguiding with Mechanical and Thermal Resilience

Advanced Functional Materials, EarlyView.
Pullulan, a biomass‐derived polysaccharide, is transformed into transparent optical fibers using a solvent‐free borax hydrogel‐spinning method. The fibers outperform PMMA with ≈200 MPa tensile strength and 200 °C stability, while uniquely guiding visible‐to‐NIR light and enabling additive‐free humidity sensing.
Yuya Fukata, Aayush Kumar Jaiswal, Ari Hokkanen, Hannes Orelma, Tadahisa Iwata   +4 more
wiley   +1 more source

The Systemic Alterations of Lipids, Alanine-Glucose Cycle and Inter-Organ Amino Acid Metabolism in Swine Model Confirms the Role of Liver in Early Phase of Septic Shock

Frontiers in Physiology, 2019
Septic shock is a medical emergency and is one of the main causes of mortality in critically ill patients. Given the pathophysiological complexity of sepsis spectrum and progression in clinical settings, animal models become essential tools to improve ...
Manuela Ferrario, Laura Brunelli, Fuhong Su, Antoine Herpain, Antoine Herpain, Roberta Pastorelli   +5 more
doaj   +1 more source

Genetic variants in SERPINA4 and SERPINA5, but not BCL2 and SIK3 are associated with acute kidney injury in critically ill patients with septic shock [PDF]

, 2017
Background: Acute kidney injury (AKI) is a multifactorial syndrome, but knowledge about its pathophysiology and possible genetic background is limited.
FINNAKI Study Grp, Kaunisto, Mari A., Pettila, Ville, Vaara, Suvi, Vilander, Laura   +4 more
core   +7 more sources

An Innovative “Tooth‐On‐Chip” Microfluidic Device Emulating the Structure and Physiology of the Dental Pulp Tissue

Advanced Healthcare Materials, EarlyView.
This work presents a “tooth‐on‐chip” device that mimics dental pulp tissue. By co‐culturing key cell types, it recreates vascular networks, stem cell niches, the odontoblast/dentine interface, and trigeminal innervation. This innovative platform provides a unique model of dental pulp structure and physiology, with significant potential for accelerating
Alessandro Cordiale, Deborah Stanco, Roberta Visone, Bernd Stadlinger, Pierfrancesco Pagella, Marco Rasponi, Thimios A. Mitsiadis   +6 more
wiley   +1 more source

Extracellular‐Matrix‐Based Materials from Decellularized Tissue: Opportunities, Challenges, and Future Directions in Regenerative Medicine

Advanced Healthcare Materials, EarlyView.
Extracellular matrix‐based materials derived from decellularized tissue (dECM) harness the tissue's native bioactivity to guide repair and regeneration across diverse clinical applications. This perspective highlights clinical uses of dECM biomaterials and advances in fabrication methods such as electrospinning and 3D printing.
Madeline Laude, Vasiliki Kolliopoulos, Antonios G. Mikos, Lisa J. White, Elizabeth Cosgriff‐Hernandez   +4 more
wiley   +1 more source

Diagnostic and prognostic value of interleukin-6, pentraxin 3, and procalcitonin levels among sepsis and septic shock patients: a prospective controlled study according to the Sepsis-3 definitions

BMC Infectious Diseases, 2019
Background This study investigated the clinical value of interleukin-6 (IL-6), pentraxin 3 (PTX3), and procalcitonin (PCT) in patients with sepsis and septic shock diagnosed according to the Third International Consensus Definitions for Sepsis and Septic
Juhyun Song, Dae Won Park, Sungwoo Moon, Han-Jin Cho, Jong Hak Park, Hyeri Seok, Won Seok Choi   +6 more
doaj   +1 more source