Results 121 to 130 of about 1,097,275 (327)

Advances in Bioprinting to Model Immune‐Mediated Skin Diseases

Advanced Healthcare Materials, EarlyView.
This review explores how 3D bioprinting drives innovation in developing in vitro skin models that mimic immune‐mediated diseases. It highlights current technologies, key applications in studying skin pathologies, and emerging challenges. The review points toward future opportunities for improving disease modeling and advancing therapeutic and cosmetic ...
Andrea Ulloa‐Fernández, Marica Markovic, Julia Fernández‐Pérez, Georg Stary, Aleksandr Ovsianikov   +4 more
wiley   +1 more source

Dual‐Functional Polyphosphoesters for Gene Delivery: Synergistic Effects of Guanidinium and Hydrophobic Side Chains in Degradable Polymers

Advanced Healthcare Materials, EarlyView.
This study presents guanidinium‐ and indole‐functionalized polyphosphoesters as degradable, non‐viral gene delivery vectors. Through precise tuning of charge density and hydrophobicity, these polymers form stable polyplexes with low toxicity. Remarkably, minor structural changes yield up to 200‐fold differences in transfection efficiency, highlighting ...
Markus Kötzsche, Andreas Dzierza, Jan Egger, Timo Rheinberger, Christin Weilandt, Frederik R. Wurm, Ivo Nischang, Dagmar Fischer, Kalina Peneva   +8 more
wiley   +1 more source

Vasodilators in Septic Shock Resuscitation: A Clinical Perspective [PDF]

, 2017
: Microcirculatory abnormalities have been shown to be frequent in patients with septic shock despite “normalization” of systemic hemodynamics. Several studies have explored the impact of vasodilator therapy (prostacyclin, inhaled nitric oxide, topic ...
Assunção, M.S.C. (Murillo Santucci Cesar), Corrêa, T.D. (Thiago Domingos), Filho, R.R. (Roberto Rabello), Lima, A.A.P. (Alexandre ), Silva, E. (Eliézer)   +4 more
core   +1 more source

Noninvasive ventilation failure in patients with hypoxemic respiratory failure: the role of sepsis and septic shock

Therapeutic Advances in Respiratory Disease, 2019
Background: Sepsis and septic shock are common in noninvasive ventilation (NIV) patients. However, studies on the association between sepsis and NIV failure are lacking.
Jun Duan, Lijuan Chen, Guopeng Liang, Weiwei Shu, Liucun Li, Ke Wang, Shengyu Wang, Xiaoyi Liu, Chunfeng He, Dehua He, Qimin Chen, Bilin Wei, Baixu Chen, Yuzhen Shu, Yao Tian, Liping Fan, Xiaoli Han, Rui Zhang, Xiangmei Yang, Yan Peng, Dong Wan, Xiaoying Chen, Lin Ye, Shijing Tian, Qiong Huang, Lei Jiang, Linfu Bai, Lintong Zhou   +27 more
doaj   +1 more source

Does metformin exposure before ICU stay have any impact on patients’ outcome? A retrospective cohort study of diabetic patients

Annals of Intensive Care, 2017
Background Impact of metformin exposure before ICU stay remains controversial. Metformin is thought to induce lactic acidosis and haemodynamic instability but may reduce ICU mortality.
Sebastien Jochmans, Jean-Emmanuel Alphonsine, Jonathan Chelly, Ly Van Phach Vong, Oumar Sy, Nathalie Rolin, Olivier Ellrodt, Mehran Monchi, Christophe Vinsonneau   +8 more
doaj   +1 more source

Micro‐Strain Responsive Near‐Infrared Mechanoluminescence for Potential Nondestructive Artificial Joint Stress Imaging

Advanced Materials, EarlyView.
In situ and real‐time stress sensing during total knee replacement procedure is expected to be realized based on near‐infrared mechanoluminescent phosphor of Sr3Sn1.98Sb0.02O6.99, which has the lowest strain sensitivity as low as 50 µst. Abstract Recently, joint replacement surgery is facing significant challenges of patient dissatisfaction and the ...
Wenhao Li, Puxian Xiong, Xiaoxin Zheng, Luyue Niu, Lugui Cui, Qingyu Wang, Bruno Viana, Pieter Dorenbos, Jianzhong Zhang, Jing Ren   +9 more
wiley   +1 more source

Tailoring Advanced Metal‐Based Nanomedicines for Adaptable Nanodynamic Disease Therapies and Theranostics

Advanced Materials, EarlyView.
This review summarizes recent advances in metal‐based nanomaterials (MBNs) as multifunctional platforms for next‐generation diagnostics and nanodynamic therapies (NDTs), highlighting their structural tunability, diverse therapeutic modalities, and broad biomedical applications in oncology and infectious disease control.
Qihang Ding, Wenhao Li, Ling Mei, Suling Luo, Jing Tao, Chongxiu Shi, Hongping Yang, Wei Feng, Yungchang Chen, Yu Chen, Jong Seung Kim, Xue Shen   +11 more
wiley   +1 more source

Multifunctional Small Intestinal Submucosa Mesh for Scarless Abdominal Wall Defect Repair

Advanced Materials Interfaces, EarlyView.
a) Schematic illustration of the SIS/PCA/Mg mesh preparation. b) Schematic illustration of the repair of full‐thickness abdominal wall defects by multifunctional and degradable SIS/PCA/Mg mesh. ABSTRACT Decellularized small intestinal submucosa (SIS) mesh used for the treatment of abdominal wall defects often suffers from a high risk of recurrence due ...
Fuxin Tang, Zehui Hou, Haonan Huang, Xingxing Xie, Shuang Chen, Wenchang Gan, Ning Ma, Taicheng Zhou   +7 more
wiley   +1 more source

Principles of fluid management and stewardship in septic shock: it is time to consider the four D’s and the four phases of fluid therapy

Annals of Intensive Care, 2018
In patients with septic shock, the administration of fluids during initial hemodynamic resuscitation remains a major therapeutic challenge. We are faced with many open questions regarding the type, dose and timing of intravenous fluid administration ...
M. Malbrain, N. Van Regenmortel, B. Saugel, B. de Tavernier, P. Van Gaal, O. Joannes-Boyau, J. Teboul, T. Rice, M. Mythen, X. Monnet   +9 more
semanticscholar   +1 more source

Information Transmission Strategies for Self‐Organized Robotic Aggregation

Advanced Robotics Research, EarlyView.
In this review, we discuss how information transmission influences the neighbor‐based self‐organized aggregation of swarm robots. We focus specifically on local interactions regarding information transfer and categorize previous studies based on the functions of the information exchanged.
Shu Leng, Zihan Li, Yifeng Shao, Jinhao Liu, Li Yu, Shuguang Li   +5 more
wiley   +1 more source