Results 131 to 140 of about 1,097,275 (327)

The Neuropathology of Septic Shock

Brain Pathology, 2004
The neuropathological correlates of encephalopathy and autonomic dysfuction in septic shock are unclear. We performed post mortem analysis of 5 brain areas susceptible to ischemia and 5 autonomic nuclei (AN) in 23 pqtients who had died in our intensive care unit (ICU) from septic shock and 8 dying from non‐septic shock as well as 5 controls who had ...
Tarek, Sharshar, Djillali, Annane, Geoffroy Lorin, de la Grandmaison, Jean Philippe, Brouland, Nicholas S, Hopkinson, Gray, Françoise   +5 more
openaire   +3 more sources

Structural Characterization and AI‐Enhanced Modeling of a Broadly Neutralizing Camelid Antibody Against SARS‐CoV‐2 Variants

Advanced Therapeutics, EarlyView.
This study characterizes a camelid antibody (B10) with potent neutralizing activity against SARS‐CoV‐2 Wildtype and Omicron variants. Through binding assays, epitope mapping, pseudovirus neutralization, and AI‐driven modeling, the antibody is shown to target conserved RBD regions in a closed Spike conformation.
Katja Hanack, Urszula Orzeł, Anja Schlör, Sourabh Mehta, Anandi Krishnan, Slawomir Filipek, Rushika Patel, Madhvi Joshi, Markus Hoffmann, Stefan Pöhlmann, Chaitanya Joshi, Dorian Liepmann, Ramasamy Paulmurugan, Venkatesan Renugopalakrishnan   +13 more
wiley   +1 more source

Fluid therapy and hemodynamic support in septic shock

Journal of Pediatric Critical Care, 2018
Sepsis remains one of the leading causes of mortality in children all over the world, especially in the developing nations. Early recognition of sepsis and septic shock facilitate the resuscitation, further reducing the morbidity and mortality related to
Milind Jambagi, Rakshay Shetty
doaj   +1 more source

Therapeutic Antibodies for Mosquito‐Borne Orthoflavivirus Infections: Discovery, Engineering Approaches, and Advances in mRNA‐Based Delivery Systems

Advanced Therapeutics, EarlyView.
This review explores how antibody engineering and display technologies are driving therapeutic advances against mosquito‐borne orthoflaviviruses such as Zika, dengue, and yellow fever viruses. It highlights diverse neutralizing targets on the envelope protein, including the conserved fusion loop, and discusses how Fc engineering, rational antigen ...
Ana Clara Barbosa Antonelli, Lucas Silva Rodrigues, Maria Clara Moura Pinheiro, Sylvia Barbosa Pinhate, Marcelo de Macedo Brígido, Andréa Queiroz Maranhão   +5 more
wiley   +1 more source

Extracellular vesicle-bound S100A8/A9 is differentially expressed in septic shock and prompts acute lung injury

Respiratory Research
Background Sepsis is a common indirect insult leading to acute respiratory distress syndrome (ARDS). Circulating extracellular vesicles (EVs) have been reported to participate in the pathogenesis of sepsis.
Jiangmei Wang, Weiliang Wu, Tingting Wen, Guoping Zheng, Guanguan Qiu, Huifeng Qian, Ruoyang Zhang, Jie Xia, Yaoqin Hu, Ruoqiong Huang, Ruoxi Zang, Zhenkai Le, Qiang Shu, Jianguo Xu   +13 more
doaj   +1 more source

Melatonin and cortisol exhibit different circadian rhythm profiles during septic shock depending on timing of onset: a prospective observational study

Annals of Intensive Care, 2018
Background Septic shock has been found to disrupt circadian rhythms. Moreover, timing of onset has been associated with different circadian profiles in experimental studies.
Eleni N. Sertaridou, Ioanna G. Chouvarda, Konstantinos I. Arvanitidis, Eirini K. Filidou, George C. Kolios, Ioannis N. Pnevmatikos, Vasilios E. Papaioannou   +6 more
doaj   +1 more source

Mechanobiological Dynamics‐Inspired Mechanomodulatory Biomaterials

Advanced Science, EarlyView.
Recent advances in biomaterial‐mediated mechanomodulation of stem cell fate, encompassing 2, 3, and 4D systems and their synergy with artificial intelligence is overviewed. By integrating knowledge from diverse fields, this review ultimately aims to inspire the design of smarter biomaterial systems that can accelerate the clinical translation of ...
Letao Yang, Pengfei Jiang, Joshua B Stein, Yannan Hou, Chaochen Zhou, Heemin Kang, Ki‐Bum Lee   +6 more
wiley   +1 more source

Identification of cuproptosis-related genes in septic shock based on bioinformatic analysis.

PLoS ONE
BackgroundSeptic shock is a life-threatening condition characterized by a failure of organ systems and a high mortality rate. Cuproptosis is a new form of cell death that is triggered by copper overload.
Jintong Zhao, Meng Zhang, Ying Wang, Feifei He, Qiang Zhang   +4 more
doaj   +1 more source

Type II Alveolar Epithelial Cells Promote Sepsis‐Induced Immunosuppression in Alveolar Macrophages via Exosomal lncRNA Rmrp Release

Advanced Science, EarlyView.
The S100A4/STAT3 axis promotes Rmrp transcription in AEC‐IIs and Rmrp expression in AEC‐II‐derived exosomes. Upon entry into AMs, Rmrp binds to and blocks the ubiquitination and degradation of ZFP36. Increased ZFP36 induced Pfkfb3 mRNA decay by binding to AREs in the 3′ UTR, curbing glycolysis and immune responses of AMs and aggravating SII and ...
Chengxi Liu, Weixia Xuan, Song Cao, Huayun Jia, Qian Wu, Xiaowu Tan, Qijie Wang, Xiaojun Li, Lisha Ding, Yaru Xiong, Meiyun Zhao, Longcheng Zheng, Yunzhu Xi, Jianhua Tan, Rong Li, Xulong Zhang, Wenjie Liu, Xu Wu   +17 more
wiley   +1 more source

Association of metformin administration after septic shock with short-term and long-term survival in septic shock patients with diabetes

Annals of Intensive Care
Background In addition to glycemic control, the anti-inflammatory effects and protective effect of metformin on sepsis have been reported in animal studies, which may be beneficial for patients with septic shock.
Bo-Yeong Jin, Sukyo Lee, Woosik Kim, Jong-Hak Park, Hanjin Cho, Sungwoo Moon, Sejoong Ahn   +6 more
doaj   +1 more source