Results 231 to 240 of about 208,314 (301)

Emerging Target Discovery Strategies Drive the Decoding of Therapeutic Power of Natural Products and Further Drug Development: A Case Study of Celastrol

Exploration, EarlyView.
Using celastrol as a case study, this review summarizes various target discovery strategies for natural products, including chemical proteomics, protein microarray, degradation‐based protein profiling, proteome‐wide label‐free approaches, network pharmacology, target‐based drug screening, and indirect strategies.
Yanbei Tu, Guiyu Dai, Yanyan Chen, Lihua Tan, Hanqing Liu, Meiwan Chen   +5 more
wiley   +1 more source

Expression of Serum LMAN2 and Sestrin2 in Septic Shock Patients and Exploration of Their Prognostic Value. [PDF]

J Inflamm Res
Chen Z, Chu Z, Jia L.
europepmc   +1 more source

Immunomodulatory Nanozymes Eradicate Intracellular Infections and Rescue Immunoparalysis for Treating Multidrug‐Resistant Bacterial Sepsis

Exploration, EarlyView.
Immunomodulatory nanozymes enable in situ macrophages engineering and orchestrate systemic innate‐adaptive immune response to eradicate intracellular bacteria and rescue immunoparalysis for treating multidrug‐resistant bacterial sepsis. ABSTRACT Sepsis and their sequelae are the leading causes of death in intensive care units, with limited therapeutic ...
Xuancheng Du, Zhenzhen Dong, Yan Yan, Yuan Gong, Meili Yuan, Chengtai Ma, Lingqi Xu, Yuanyuan Qu, Minhan Qu, Peng Pan, Weifeng Li, Wenyan Hao, Yingyi Yang, Xiangdong Liu, Mingwen Zhao, Zhenjiang Bai, Jiang Huai Wang, Jian Wang, Yong‐Qiang Li, Huiting Zhou   +19 more
wiley   +1 more source

Pronounced effects of the sepsis-obesity paradox in elderly and male individuals without septic shock and the role of immune-inflammatory status: an analysis of MIMIC-IV data. [PDF]

BMC Infect Dis
Xu Z, Li Z, Zhang R, Peng G, Ge J, Luo S, Liu C, Zeng L, Deng J.   +8 more
europepmc   +1 more source

Actinidia spp. (Kiwifruit): A Comprehensive Review of Its Nutraceutical Potential in Disease Mitigation and Health Enhancement

Food Frontiers, EarlyView.
Nutraceutical Potential in Disease Mitigation and Health Enhancement of Actinidia spp. (Kiwifruit) ABSTRACT This review offers an in‐depth exploration of the Actinidia species (kiwifruit) nutritional composition, the pivotal role of its primary bioactive compounds, and their potential applications across the aforementioned health concerns. Furthermore,
Allah Rakha, Nida Rehman, Rimsha Anwar, Hina Rasheed, Roshina Rabail, Zuhaib F. Bhat, Amin Mousavi Khaneghah, Rana Muhammad Aadil   +7 more
wiley   +1 more source

The Association Between Central Venous Pressure and Acute Kidney Injury Development in Patients with Septic Shock. [PDF]

J Clin Med
Nikravangolsefid N, Ninan J, Suppadungsuk S, Singh W, Kashani KB.   +4 more
europepmc   +1 more source

HA380 Hemoperfusion Combined with Continuous Veno-Venous Hemodiafiltration for the Treatment of Septic Shock. [PDF]

Bioengineering (Basel)
An Y, Guo Y, Zhou W, He Q, Li Z, Sui X, Yi X, Yi H.   +7 more
europepmc   +1 more source

Prognostic Factors for Free Flap Failure in Head and Neck Reconstruction

Head &Neck, EarlyView.
ABSTRACT Background The failure rate of free flaps varies from 0.8% to 10.6% in the literature in head and neck reconstruction. The primary objective was to identify prognostic factors for free flap failure. Methods We prospectively included all consecutive free flaps performed between August 2021 and January 2024, and used a multivariate Cox ...
Quentin Hennocq, Jean‐Baptiste Caruhel, Mourad Benassarou, Jebrane Bouaoud, André Chaine, Angélique Girod, Nicolas Graillon, Sylvie Testelin, Mélika Amor‐Sahli, Jean‐Philippe Foy, Chloé Bertolus   +10 more
wiley   +1 more source

Influence of age-adjusted shock index trajectories on 30-day mortality for critical patients with septic shock. [PDF]

Front Med (Lausanne)
Yue S, Hou X, Wang Y, Xu Z, Li X, Wang J, Ye S, Wu J.   +7 more
europepmc   +1 more source

Postoperative Management Following Endoscopic Skull Base Reconstruction: A Multidisciplinary Cross‐Sectional Survey

Head &Neck, EarlyView.
ABSTRACT Background There is limited consensus on management protocols and practice patterns following endoscopic skull base surgery (ESBS). Methods An online‐based survey focusing on ESBS practice patterns was anonymously distributed to the American Rhinologic Society, North American Skull Base Society, and American Head and Neck Society Skull Base ...
Khodayar Goshtasbi, Arash Abiri, Vidit Talati, Jagatkumar A. Patel, Theodore V. Nguyen, Jonathan C. Pang, John R. Craig, Peter Papagiannopoulos, Katie M. Phillips, Bobby A. Tajudeen, Nithin D. Adappa, James N. Palmer, Ahmad R. Sedaghat, Eric W. Wang, Shirley Y. Su, Edward C. Kuan   +15 more
wiley   +1 more source