Results 21 to 30 of about 997,380 (276)
A model of porcine polymicrobial septic shock
Intensive Care Medicine Experimental, 2023 Background Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. Mortality of patients with sepsis is high and largely unchanged throughout the past decades.
Finnja Marie Zurek-Leffers +12 more
doaj +1 more source
Frontiers in Immunology, 2022 Objective To date, there are no studies regarding the lactylation profile and its role in critically ill patients. Thus, we aimed to examine expression of histone H3 lysine 18 (H3K18) lactylation and its role in patients with septic shock.
X. Chu +13 more
semanticscholar +1 more source
Frequency and mortality of sepsis and septic shock in China: a systematic review and meta-analysis
BMC Infectious Diseases, 2022 Background Sepsis, a life-threatening organ dysfunction induced by infection, is a major public health problem. This study aimed to evaluate the frequency and mortality of sepsis, severe sepsis, and septic shock in China.
Yan-Cun Liu +8 more
semanticscholar +1 more source
Septic shock: perspective methods of diagnostics and therapy based on immunopathogenesis
Медицинская иммунология, 2020 Based on the III International Consensus on the definition of Sepsis and Septic Shock (Sepsis-3), the modern definition of septic shock was proposed: “Septic shock is a type of sepsis that is accompanied by severe hemodynamic, metabolic and cellular ...
L. I. Gomanova
doaj +1 more source
F1000 Medicine Reports, 2010 Although several successful clinical trials in the last 2-3 years have been greeted with enthusiasm by intensivists, severe sepsis and septic shock still have increasing incidence and more or less unchanged mortality. Within the last few years, the progress in sepsis research covering definitions, epidemiology, pathophysiology, diagnosis, and standard ...
Gerlach, Herwig, Toussaint, Susanne
openaire +2 more sources
Critical Care, 2021 While recommended by international societal guidelines in the paediatric population, the use of venoarterial extracorporeal membrane oxygenation (VA ECMO) as mechanical circulatory support for refractory septic shock in adults is controversial.
R. Ling +7 more
semanticscholar +1 more source
The Role of Complement System in Septic Shock
Clinical and Developmental Immunology, 2012 Septic shock is a critical clinical condition with a high mortality rate. A better understanding of the underlying mechanisms is important to develop effective therapies.
Jean Charchaflieh +8 more
doaj +1 more source
Characterization of Early Peripheral Immune Responses in Patients with Sepsis and Septic Shock
Biomedicines, 2022 (1) Background: Sepsis is a life-threatening condition caused by an abnormal host response to infection that produces altered physiological responses causing tissue damage and can result in organ dysfunction and, in some cases, death.
Jesús Beltrán-García +11 more
doaj +1 more source
Management of sepsis and septic shock in the emergency department
Internal and Emergency Medicine, 2021 Early management of sepsis and septic shock is crucial for patients’ prognosis. As the Emergency Department (ED) is the place where the first medical contact for septic patients is likely to occur, emergency physicians play an essential role in the early
F. Gavelli, L. Castello, G. Avanzi
semanticscholar +1 more source
Critical Care, 2021 Background Timely administration of antibiotics is one of the most important interventions in reducing mortality in sepsis. However, administering antibiotics within a strict time threshold in all patients suspected with sepsis will require huge amount ...
Y. Im +38 more
semanticscholar +1 more source