Septic shock: perspective methods of diagnostics and therapy based on immunopathogenesis
Медицинская иммунология, 2020 Based on the III International Consensus on the definition of Sepsis and Septic Shock (Sepsis-3), the modern definition of septic shock was proposed: “Septic shock is a type of sepsis that is accompanied by severe hemodynamic, metabolic and cellular ...
L. I. Gomanova
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Proenkephalin A 119-159 (Penkid) Is an Early Biomarker of Septic Acute Kidney Injury: The Kidney in Sepsis and Septic Shock (Kid-SSS) Study [PDF]
, 2018 Introduction: Sepsis is the leading cause of acute kidney injury (AKI) in critically ill patients. The Kidney in Sepsis and Septic Shock (Kid-SSS) study evaluated the value of proenkephalin A 119-159 (penkid)—a sensitive biomarker of glomerular function,
Antonelli, M. +25 more
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Characterization of Early Peripheral Immune Responses in Patients with Sepsis and Septic Shock
Biomedicines, 2022 (1) Background: Sepsis is a life-threatening condition caused by an abnormal host response to infection that produces altered physiological responses causing tissue damage and can result in organ dysfunction and, in some cases, death.
Jesús Beltrán-García +11 more
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The Role of Complement System in Septic Shock
Clinical and Developmental Immunology, 2012 Septic shock is a critical clinical condition with a high mortality rate. A better understanding of the underlying mechanisms is important to develop effective therapies.
Jean Charchaflieh +8 more
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Risk factors and outcomes for ineffective empiric treatment of sepsis caused by gram-negative pathogens: Stratification by onset of infection [PDF]
, 2017 Sepsis and septic shock remain serious consequences of infections, with reported mortality rates in excess of 40 percent. Timely antibiotic therapy in cases of sepsis and septic shock is recognized as an important determinant of outcome.
Hampton, Nicholas +2 more
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Changes in Circulating Procalcitonin Versus C-Reactive Protein in Predicting Evolution of Infectious Disease in Febrile, Critically Ill Patients [PDF]
, 2013 Objective:Although absolute values for C-reactive protein (CRP) and procalcitonin (PCT) are well known to predict sepsis in the critically ill, it remains unclear how changes in CRP and PCT compare in predicting evolution of: infectious disease ...
Groeneveld, A.B.J. (Johan) +1 more
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Fluid balance and cardiac function in septic shock as predictors of hospital mortality [PDF]
, 2013 INTRODUCTION: Septic shock is a major cause of morbidity and mortality throughout the world. Unfortunately, the optimal fluid management of septic shock is unknown and currently is empirical.
Doherty, Joshua A +5 more
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Effect of stress doses of hydrocortisone on S-100B vs. interleukin-8 and polymorphonuclear elastase levels in human septic shock [PDF]
, 2005 Stress doses of hydrocortisone a re known to have immunomodulatory effects in patients with hyperdynamic septic shock. The prognosis correlates with the presence and severity of septic encephalopathy. However, neurological evaluation is influenced by the
Anderson +46 more
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Terlipressin or norepinephrine in septic shock: do we have the answer? [PDF]
, 2019 Comment on Terlipressin versus norepinephrine as infusion in patients with septic shock: a multicentre, randomised, double-blinded trial.
Russell, James A., Williams, Mark D.
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Characteristics and Outcomes of Patients with Vasoplegic Versus Tissue Dysoxic Septic Shock [PDF]
, 2013 Background: The current consensus definition of septic shock requires hypotension after adequate fluid challenge or vasopressor requirement. Some patients with septic shock present with hypotension and hyperlactatemia greater than 2 mmol/L (tissue ...
Jones, Alan E +6 more
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