Results 31 to 40 of about 1,097,275 (327)

Characteristics and Outcomes of Patients with Vasoplegic Versus Tissue Dysoxic Septic Shock [PDF]

, 2013
Background: The current consensus definition of septic shock requires hypotension after adequate fluid challenge or vasopressor requirement. Some patients with septic shock present with hypotension and hyperlactatemia greater than 2 mmol/L (tissue ...
Jones, Alan E, Kline, Jeffrey A., Puskarich, Michael A, Shapiro, Nathan I, Sterling, Sarah A, Summers, Richard L, Trzeciak, Stephen   +6 more
core   +1 more source

Mortality in sepsis and septic shock in Europe, North America and Australia between 2009 and 2019— results from a systematic review and meta-analysis

Critical Care, 2020
Background Sepsis and septic shock remain drivers for mortality in critically ill patients. The heterogeneity of the syndrome hinders the generation of reproducible numbers on mortality risks. Consequently, mortality rates range from 15 to 56%.
M. Bauer, H. Gerlach, T. Vogelmann, F. Preissing, J. Stiefel, D. Adam   +5 more
semanticscholar   +1 more source

Venoarterial extracorporeal membrane oxygenation as mechanical circulatory support in adult septic shock: a systematic review and meta-analysis with individual participant data meta-regression analysis

Critical Care, 2021
While recommended by international societal guidelines in the paediatric population, the use of venoarterial extracorporeal membrane oxygenation (VA ECMO) as mechanical circulatory support for refractory septic shock in adults is controversial.
R. Ling, K. Ramanathan, W. H. Poon, C. Tan, N. Brechot, D. Brodie, A. Combes, G. MacLaren   +7 more
semanticscholar   +1 more source

The Role of Complement System in Septic Shock

Clinical and Developmental Immunology, 2012
Septic shock is a critical clinical condition with a high mortality rate. A better understanding of the underlying mechanisms is important to develop effective therapies.
Jean Charchaflieh, Jiandong Wei, Georges Labaze, Yunfang Joan Hou, Benjamin Babarsh, Helen Stutz, Haekyung Lee, Samrat Worah, Ming Zhang   +8 more
doaj   +1 more source

Is there NO treatment for severe sepsis? [PDF]

, 2008
Sepsis is a systemic inflammatory response syndrome in the presence of suspected or proven infection, and it may progress to or encompass organ failure (severe sepsis) and hypotension (septic shock).
Bredan, Amin, Cauwels, Anje
core   +2 more sources

Time-to-antibiotics and clinical outcomes in patients with sepsis and septic shock: a prospective nationwide multicenter cohort study

Critical Care, 2021
Background Timely administration of antibiotics is one of the most important interventions in reducing mortality in sepsis. However, administering antibiotics within a strict time threshold in all patients suspected with sepsis will require huge amount ...
Y. Im, D. Kang, R. Ko, Y. Lee, S. Lim, Sunghoon Park, S. J. Na, C. Chung, M. Park, D. Oh, C. Lim, G. Suh, Chae-Man Sang-Bum Dong Kyu Gee Young Kyeongman Ryoung-Eun Y Lim Hong Oh Suh Jeon Ko Cho Lee Lim Park Heo Lee K, C. Lim, Sang-Bum Hong, D. Oh, G. Suh, K. Jeon, R. Ko, Y. Cho, Y. Lee, S. Lim, Sunghoon Park, J. Heo, Jae-myeong Lee, K. Kim, Youjin Chang, Sang-Min Lee, Suk-Kyung Hong, W. Cho, Sanghyeon Kwak, Heung Bum Lee, J. Ahn, G. Seong, Song-I Lee, T. Park, Su Hwan Lee, E. Choi, J. Moon   +38 more
semanticscholar   +1 more source

Diagnostic value of Pentraxin-3 in patients with sepsis and septic shock in accordance with latest sepsis-3 definitions [PDF]

, 2017
Background: Pentraxin-3 (PTX-3) is an acute-phase protein involved in inflammatory and infectious processes. This study assesses its diagnostic and prognostic value in patients with sepsis or septic shock in a medical intensive care unit (ICU). Methods:
A Mantovani, AP Wheeler, B Bottazzi, B Bottazzi, B Bottazzi, B Muller, C Garlanda, C Garlanda, C Henriquez-Camacho, DC Angus, Dominic Lepiorz, Dominic Pauly, E Rivers, F Bloos, F Breviarios, F Cuello, F Moalli, GW Lee, Ibrahim Akin, J Cohen, J Silvestre, M Behnes, M Shankar-Hari, M Singer, Martin Borggrefe, Max Barre, MD Kruif De, Michael Behnes, MM Levy, MM Levy, P Caironi, PC Reading, R Huttunen, R Uusitalo-Seppala, RC Bone, RP Dellinger, RP Dellinger, S Bastrup-Birk, S Bastrup-Birk, S Jaillon, S Kibe, S Liu, Siegfried Lang, Sonja Hamed, T Mauri, Thomas Bertsch, Tobias Becher, Ursula Hoffmann, W Knaus   +48 more
core   +1 more source

Changes in Circulating Procalcitonin Versus C-Reactive Protein in Predicting Evolution of Infectious Disease in Febrile, Critically Ill Patients [PDF]

, 2013
Objective:Although absolute values for C-reactive protein (CRP) and procalcitonin (PCT) are well known to predict sepsis in the critically ill, it remains unclear how changes in CRP and PCT compare in predicting evolution of: infectious disease ...
Groeneveld, A.B.J. (Johan), Hoeboer, S.H. (Sandra)   +1 more
core   +6 more sources

Surviving Sepsis Campaign: International Guidelines for Management of Severe Sepsis and Septic Shock, 2012

Intensive Care Medicine, 2013
ObjectiveTo provide an update to the “Surviving Sepsis Campaign Guidelines for Management of Severe Sepsis and Septic Shock,” last published in 2008.DesignA consensus committee of 68 international experts representing 30 international organizations was ...
R. Dellinger, M. Levy, A. Rhodes, D. Annane, H. Gerlach, S. Opal, J. Sevransky, C. Sprung, I. Douglas, R. Jaeschke, T. Osborn, M. Nunnally, S. Townsend, K. Reinhart, R. Kleinpell, D. Angus, C. Deutschman, F. Machado, G. Rubenfeld, S. Webb, R. Beale, J. Vincent, R. Moreno, The Surviving Sepsis Campaign Guidelines Committee inc Subgroup   +23 more
semanticscholar   +1 more source

Endothelial damage in septic shock patients as evidenced by circulating syndecan-1, sphingosine-1-phosphate and soluble VE-cadherin: a substudy of ALBIOS

Critical Care, 2021
Background Septic shock is characterized by breakdown of the endothelial glycocalyx and endothelial damage, contributing to fluid extravasation, organ failure and death. Albumin has shown benefit in septic shock patients.
Arianna Piotti, D. Novelli, J. Meessen, D. Ferlicca, Sara Coppolecchia, A. Marino, G. Salati, M. Savioli, G. Grasselli, G. Bellani, A. Pesenti, S. Masson, P. Caironi, L. Gattinoni, M. Gobbi, C. Fracasso, R. Latini, Paola Francesca Riccarda Andrea Chiara Beatrice Stefano Bruzzone Pagan Russo Confalonieri Abbruzzese Vergn, P. Bruzzone, F. Pagan, R. Russo, A. Confalonieri, C. Abbruzzese, B. Vergnano, S. Faenza, A. Siniscalchi, E. Pierucci, A. Noto, A. Pezzi, P. Spanu, V. Parrini, R. Oggioni, G. Pasetti, M. Casadio, Rosa Buontempo, S. Carrer, F. Piccoli, Tatiana Rizzi, A. Caricato, M. La Sala, A. Antonaci, P. Fassini, Silvia Paganini, V. Porta, G. Moise, Silvia Marell, M. Furia, Maria Cristina Urbano, Roberta Carobbi, Simona Poleni, H. Kandil, A. Ballotta, F. Bettini, M. Sanseverino, A. Gatta, F. Cecchini, Luca Guatteri, G. Ciceri, F. Raimondi, Roberto Colombo, S. Ferraris, Massimo Borelli, V. Bellato, Franco Cancellieri, Silvia Senni, Ester Bertocchi, P. Ferri, Gianpietro Moioli, A. Fedele, A. Molin, G. Salati, P. Salsi, E. Brunori, D. Elisei, Giuseppe Maggio, F. Nicola, M. Cavana, G. Morelli, A. Guarino, Michele Isetta, G. Tulli, V. Mangani, N. Rossi, Marta Ferrari, F. Bona, Monica Vay, Teresa M. Bartoli, Mauro Gallo, K. Vettoretto, M. D. Morte, E. Boselli, D. Puscio, Monia Bovo, A. Galzerano, Manuela Carli, G. Zagara   +95 more
semanticscholar   +1 more source