Results 41 to 50 of about 997,380 (276)

Effect of Vitamin C, Hydrocortisone, and Thiamine vs Hydrocortisone Alone on Time Alive and Free of Vasopressor Support Among Patients With Septic Shock: The VITAMINS Randomized Clinical Trial.

Journal of the American Medical Association (JAMA), 2020
Importance It is unclear whether vitamin C, hydrocortisone, and thiamine are more effective than hydrocortisone alone in expediting resolution of septic shock.
T. Fujii, N. Luethi, P. Young, D. Frei, G. Eastwood, C. French, A. Deane, Y. Shehabi, L. Hajjar, G. Oliveira, A. Udy, N. Orford, S. Edney, A. Hunt, H. Judd, L. Bitker, L. Cioccari, T. Naorungroj, Fumitaka Yanase, S. Bates, F. McGain, Elizabeth P Hudson, W. Al-Bassam, D. B. Dwivedi, C. Peppin, P. Mccracken, J. Orosz, M. Bailey, R. Bellomo   +28 more
semanticscholar   +1 more source

Identification of transcriptomics biomarkers for the early prediction of the prognosis of septic shock from pneumopathies

BMC Infectious Diseases, 2021
Background Identifying the biological subclasses of septic shock might provide specific targeted therapies for the treatment and prognosis of septic shock. It might be possible to find biological markers for the early prediction of septic shock prognosis.
Songchang Shi, Xiaobin Pan, Hangwei Feng, Shujuan Zhang, Songjing Shi, Wei Lin   +5 more
doaj   +1 more source

Association of CD14 rs2569190 polymorphism with mortality in shock septic patients who underwent major cardiac or abdominal surgery: A retrospective study

Scientific Reports, 2018
The aim of this study was to investigate the relationship between the CD14 rs2569190 polymorphism and death related to septic shock in white European patients who underwent major cardiac or abdominal surgery.
M. Jiménez-Sousa, Pilar Liu, L. Medrano, A. Fernández-Rodríguez, R. Almansa, E. Gómez-Sánchez, Lucía Rico, M. Lorenzo, A. Fadrique, E. Tamayo, S. Resino   +10 more
semanticscholar   +1 more source

Characteristics of Sepsis-2 septic shock patients failing to satisfy the Sepsis-3 septic shock definition: an analysis of real-time collected data

Annals of Intensive Care, 2021
Background Baseline characteristics and disease severity of patients with septic shock according to the new Sepsis-3 definition may differ from patients that only comply with the Sepsis-2 definition.
Joris Vermassen, Johan Decruyenaere, Liesbet De Bus, Pieter Depuydt, Kirsten Colpaert   +4 more
doaj   +1 more source

International Consensus Criteria for Pediatric Sepsis and Septic Shock.

Journal of the American Medical Association (JAMA)
Importance Sepsis is a leading cause of death among children worldwide. Current pediatric-specific criteria for sepsis were published in 2005 based on expert opinion.
L. Schlapbach, R. S. Watson, L. Sorce, Andrew C Argent, Kusum Menon, Mark W. Hall, S. Akech, David J. Albers, Elizabeth R. Alpern, F. Balamuth, M. Bembea, Paolo Biban, E. Carrol, K. Chiotos, M. Chisti, Peter E. DeWitt, Idris V. R. Evans, Cláudio Flauzino de Oliveira, Christopher M Horvat, D. Inwald, P. Ishimine, J. Jaramillo-Bustamante, Michael Levin, R. Lodha, Blake Martin, Simon Nadel, Satoshi Nakagawa, Mark J. Peters, Adrienne G. Randolph, S. Ranjit, Margaret N Rebull, Seth Russell, Halden F. Scott, D. D. de Souza, P. Tissières, Scott L. Weiss, M. Wiens, James L Wynn, N. Kissoon, Jerry J. Zimmerman, L. Sanchez-Pinto, Tellen D. Bennett, Juliane Bubeck Wardenburg   +42 more
semanticscholar   +1 more source

Association of annual hospital septic shock case volume and hospital mortality

Critical Care, 2022
Background The burden of sepsis remains high in China. The relationship between case volume and hospital mortality among patients with septic shock, the most severe complication of sepsis, is unknown in China.
Yan Chen, Xu-dong Ma, Xiao-hui Kang, Si-fa Gao, Jin-min Peng, Shan Li, Da-wei Liu, Xiang Zhou, Li Weng, Bin Du, China National Critical Care Quality Control Center Group   +10 more
doaj   +1 more source

Development and Validation of the Phoenix Criteria for Pediatric Sepsis and Septic Shock.

Journal of the American Medical Association (JAMA)
Importance The Society of Critical Care Medicine Pediatric Sepsis Definition Task Force sought to develop and validate new clinical criteria for pediatric sepsis and septic shock using measures of organ dysfunction through a data-driven approach ...
L. Sanchez-Pinto, Tellen D. Bennett, Peter E. DeWitt, Seth Russell, Margaret N Rebull, Blake Martin, S. Akech, David J. Albers, Elizabeth R. Alpern, F. Balamuth, M. Bembea, M. Chisti, Idris V. R. Evans, Christopher M Horvat, J. Jaramillo-Bustamante, N. Kissoon, Kusum Menon, Halden F. Scott, Scott L. Weiss, M. Wiens, Jerry J. Zimmerman, Andrew C Argent, L. Sorce, L. Schlapbach, R. S. Watson, Paolo Biban, E. Carrol, K. Chiotos, Cláudio Flauzino de Oliveira, Mark W. Hall, D. Inwald, P. Ishimine, Michael Levin, R. Lodha, Simon Nadel, Satoshi Nakagawa, Mark J. Peters, Adrienne G. Randolph, S. Ranjit, Daniela Carla de Souza, P. Tissières, James L Wynn   +41 more
semanticscholar   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Septic shock

Journal of British Surgery, 1975
Abstract The problems associated with septic shock are highlighted, including those which arose during a 3-year prospective study. Mortality in the first year of the study was 71 per cent, falling to 38 per cent in the third year. The reasons, for this fall are detailed. The pattern of survival times changed over the 3 years, giving rise
openaire   +4 more sources

Clinical characteristics associated with septic shock complicating hypothermia: a retrospective cohort study from the MIMIC-IV database

European Journal of Medical Research
Background Septic shock, a severe consequence of sepsis, has a high mortality rate. Hypothermia can aggravate the state of septic shock patients, which influences therapeutic response and overall prognosis.
Fen Tan, Jinxiu Li, Yang Xiao, Chenfang Wu   +3 more
doaj   +1 more source