Results 121 to 130 of about 32,738 (234)

Anti-PD-L1 antibody ASC22 in combination with a histone deacetylase inhibitor chidamide as a "shock and kill" strategy for ART-free virological control: a phase II single-arm study. [PDF]

Signal Transduct Target Ther
Wu L, Zheng Z, Xun J, Liu L, Wang J, Zhang X, Shao Y, Shen Y, Zhang R, Zhang M, Sun M, Qi T, Wang Z, Xu S, Song W, Tang Y, Zhao B, Song Z, Routy JP, Lu H, Chen J.   +20 more
europepmc   +1 more source

A qualitative evaluation of a community‐based approach to protected area law enforcement

People and Nature, EarlyView.
Abstract People living in and around terrestrial and marine protected areas can contribute to protected area law enforcement in different ways. While the involvement of local residents is considered important for bringing benefits to both conservation and people, evaluations of community‐based approaches to protected area law enforcement are limited ...
William Sharkey, Aidan Keane, Pablo Sinovas, Vimean Huot, Rachna Thim, Maliya Yorn, E. J. Milner‐Gulland   +6 more
wiley   +1 more source

Human–wildlife coexistence and social context: Evidence from farmer communities in southern Sri Lanka

People and Nature, EarlyView.
Abstract Studies on human–wildlife interactions (HWI) often focus on conflict mitigation studies, thus overlooking underlying factors that influence community decisions to coexist with wildlife. To address this knowledge gap, we collected empirical evidence of how community interactions with wildlife are shaped by their social contexts.
Anuradhi Dulangi Jayasinghe, Georgette Leah Burns, Johanna Nalau, Duan Biggs   +3 more
wiley   +1 more source

Targeted shock-and-kill HIV-1 gene therapy approach combining CRISPR activation, suicide gene tBid and retargeted adenovirus delivery. [PDF]

Gene Ther
Klinnert S, Schenkel CD, Freitag PC, Günthard HF, Plückthun A, Metzner KJ.   +5 more
europepmc   +1 more source

Resilience for restoration: Insights from the Northern Great Plains native seed system

People and Nature, EarlyView.
Abstract Native plants are essential to ecological restoration and culturally important to local and Tribal communities, yet native seed systems across the United States (US) struggle to meet restoration demand. In the US Northern Great Plains, land conversion of native ecosystems means restoration potential is high but constrained by an underdeveloped
Elena Friedman, Lauren Redmore, Lora Perkins, Jennifer Zavaleta Cheek   +3 more
wiley   +1 more source

Enterovirus infections in children

Pediatric Investigation, EarlyView.
Enteroviruses (EVs) are major pathogens causing a wide spectrum of diseases in children worldwide. This review summarizes the epidemiology, virology, viral replication, and virus‐host interactions of EVs. It also highlights current advances in clinical diagnosis, antiviral therapies, and vaccine development, providing insights into future strategies ...
Xiangpeng Chen, Lingyun Guo, Xiaobo Lei, Linqing Zhao, Mingyan Hei, Jun Shen, Ju Yin, Fei Li, Jikui Deng, Gang Liu, Yong Zhang, Zhengde Xie   +11 more
wiley   +1 more source

Precision immunomodulation for pediatric hemophagocytic lymphohistiocytosis in intensive care

Pediatric Investigation, EarlyView.
This review presents a bedside framework for recognizing pediatric hemophagocytic lymphohistiocytosis and cytokine storm, stabilizing organ dysfunction, identifying the underlying phenotype, selecting targeted immunomodulation, considering extracorporeal adjuncts, and reassessing response within 24–72 h. ABSTRACT Hemophagocytic lymphohistiocytosis (HLH)
Weerapong Lilitwat, Prakreeti Bhandari
wiley   +1 more source

Time‐Resolved Effects of Cold Atmospheric Plasma on E. coli GW‐AmxH19 Transcriptome and Proteome in an Emulated Wastewater Environment

PROTEOMICS, EarlyView.
ABSTRACT Cold atmospheric plasma (CAP) is effective against a variety of microorganisms. Here, we described effects on an Escherichia coli strain isolated from hospital wastewater caused by treatment with physical plasma. E. coli GW‐AmxH19 was incubated in artificial wastewater and treated for 15 min with CAP.
Jörg Bernhardt, Dominik Schneider, Julia Rielicke, Susanne Sievers, Veronika Hahn, Mechthild Bömeke, Anja Poehlein, Dirk Albrecht, Juergen F. Kolb, Katharina Riedel, Rolf Daniel, Daniela Zühlke   +11 more
wiley   +1 more source

Aboveground herbivory elevates belowground rhizosphere volatile organic compound concentrations in ambient and polluted air, independent of volatile sampling methodology

PLANTS, PEOPLE, PLANET, EarlyView.
The effect of air pollution on plants is still underexplored, especially belowground. We used a field facility that released diesel exhaust and ozone at concentrations equivalent to those near a busy road in Reading, UK, to measure belowground gas exchange of Scots pine together with feeding by large pine weevils, a major pest of conifers.
Tihomir Simin, Luke Bell, James M. W. Ryalls, Robbie D. Girling, Oliver E. I. Welling, Neil J. Mullinger, Muhammad Usman Rasheed, James D. Blande   +7 more
wiley   +1 more source

Sublethal herbicide exposure alters cotton susceptibility to aphid infestation

Pest Management Science, EarlyView.
Sublethal herbicide exposure altered cotton susceptibility to aphids. Aphid severity was highest when applications occurred at early vegetative stages and declined as the crop matured. In glasshouse, herbicide effects were dose‐dependent. Abstract BACKGROUND Herbicides remain vital tools for weed control, yet their effects can extend beyond weeds to ...
Purushottam Gyawali, Ubaldo Torres, David L Kerns, Gregory A Sword, Muthukumar V Bagavathiannan   +4 more
wiley   +1 more source