Results 191 to 200 of about 32,738 (234)

Cardiopulmonary Failure in Hantavirus Disease: Mechanisms, Recognition, and ECMO-Based Management. [PDF]

Viruses
Lee DS, Hasan A.
europepmc   +1 more source

Next-Generation HIV-1 Therapeutics in Co-Endemic Settings. [PDF]

Biomedicines
Ngo B, Sutton RE.
europepmc   +1 more source

Host restriction factors and p17-Driven inflammaging in HIV-1: From molecular pathogenesis to functional cure. [PDF]

AIMS Microbiol
Nitsotolis T, Assimakopoulos SF, Kouriannidi E, Lagadinou M, Papalexandrou A, Ioannou P, Marangos M, Milionis H, Christaki E.   +8 more
europepmc   +1 more source

Fc-engineered broadly neutralizing antibodies overcome cytokine-induced CD16 cleavage to drive potent ADCC against diverse HIV-1 strains. [PDF]

mBio
Melo C, Murphy T, Holmberg CS, Kelly M, McMahon EK, Lochner JS, Lynch RM, Bosque A.   +7 more
europepmc   +1 more source

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HIV “shock and kill” therapy: In need of revision

Antiviral Research, 2019
The implementation of antiretroviral therapy 23 years ago has rendered HIV infection clinically manageable. However, the disease remains incurable, since it establishes latent proviral reservoirs, which in turn can stochastically begin reproducing viral particles throughout the patient's lifetime.
Albert Jordan, Erik Abner
exaly   +3 more sources

Shock Therapy Helps Kill Cancer Tumors

Science, 1992
exaly   +5 more sources

Reactivation of latent HIV moves shock-and-kill treatments forward [PDF]

Nature, 2020
HIV-1 can evade the immune system by hiding out in a dormant form. Two studies describe interventions that can effectively reactivate the latent virus in animals, potentially rendering it vulnerable to immune-mediated death. Treatments that can reactivate latent HIV and SIV in animals.
Mathias Lichterfeld
exaly   +2 more sources

Modeling the cytotoxicity of Romidepsin reveals the ineffectiveness of this drug in the “shock and kill” strategy

Chaos, Solitons and Fractals, 2023
Yuming Chen, Ting Guo
exaly   +2 more sources

Understanding Shock and Kill

The Meducator, 2018
The proviral latency of human immunodeficiency virus (HIV) remains a principal obstacle to curing the infection and halting disease pathogenesis. In fact, HIV infection remainsincurable due to a long-lived latent reservoir of HIV within the central nervous system (CNS), as well as the most impervious reservoir, CD4+ T cells.
Sarah Ge, Parsa Mehraban Far, Devin Roshan   +2 more
openaire   +1 more source