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6-Shogaol Mitigates Sepsis-Associated Hepatic Injury through Transcriptional Regulation
Nutrients, 2021 Sepsis-associated liver dysfunction presents a significant public health problem. 6-Shogaol is the key bioactive component in dry ginger, which has antioxidant and anti-inflammation capacity. The present study aims to investigate the preventive effect of
Xiaoxuan Guo, Yongzhong Qian
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International Journal of Molecular Sciences, 2012 In this work, one of Zingiber officinale components, 10-shogaol, was tested with 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging, metal chelating ability, and reducing power to show antioxidant activity. 10-Shogaol promoted human normal epidermal
You-Cheng Hseu +2 more
exaly +3 more sources
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Pharmacokinetics of Gingerols, Shogaols, and Their Metabolites in Asthma Patients
Journal of Agricultural and Food Chemistry, 20226-Gingerol and 6-shogaol are the most abundant gingerols and shogaols in ginger root and have been shown to reduce the asthmatic phenotype in murine models of asthma. Several studies have described the pharmacokinetics of gingerols and shogaols in humans following the oral ingestion of ginger, while little was known about the metabolism of these ...
Shuwei Zhang +5 more
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The Stability of Gingerol and Shogaol in Aqueous Solutions
Journal of Pharmaceutical Sciences, 2001Gingerols, pungent principles of ginger (the rhizome of Zingiber officinale), are biologically active components that may make a significant contribution towards medicinal applications of ginger and some products derived from ginger. Gingerols, however, are thermally labile due to the presence of a beta-hydroxy keto group in the structure, and undergo ...
S, Bhattarai, V H, Tran, C C, Duke
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Glucuronidation and its impact on the bioactivity of [6]-shogaol
Molecular Nutrition & Food Research, 2017-shogaol (6S) from ginger has been reported to have diverse bioactivities and can be widely metabolized in animals and humans; however, the impact of glucuronidation on its bioactivity is still largely unknown. This study investigates the glucuronidation of 6S and its effect on cell cytotoxicity and Nrf2-inducing activities of 6S.The glucuronidated ...
Pei, Wang +3 more
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Gingerol, Shogaol and Paradol: The Chemistry of Pungent Ginger Constituents
2020Ginger (Zingiber officinale Roscoe) rhizomes are well-known for their aromatic properties, being used to impart a characteristic pungent flavour to a variety of food and beverage products. The major pungent compounds are the gingerols and their derivatives, while numerous volatile compounds contribute additional aromatic flavour overtones. Ginger forms
Johnson, Joel +2 more
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Investigating the Anti-Cancer Properties of 6-Shogaol in Zingiber officinale
Critical Reviews™ in Oncogenesis, 2022Cancer is ranked as the first or second cause of death in 112 countries across the world with an estimated 19.3 million new cases of cancer along with 10 million deaths occurring in 2020. Colon cancer is the second most common cancer in women and the fourth most common cancer worldwide.
Sowsan, Hafuth, Sukhpal, Randhawa
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Additive Capacity of [6]-Shogaol and Epicatechin To Trap Methylglyoxal
Journal of Agricultural and Food Chemistry, 2017Methylglyoxal (MGO), a reactive dicarbonyl species, is thought to contribute to the development of long-term pathological diabetes as a direct toxin or as an active precursor of advanced glycation end products (AGEs). Trapping MGO by dietary phenols to inhibit the MGO induced AGE formation is an approach for alleviating diabetic complications.
Qiju Huang +4 more
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VietNam Military Medical Unisversity
Objectives: To optimally extract the potential phytochemical “6-shogaol” from fermented shogaol-enriched ginger. Methods: Extraction process parameters were investigated using 6-shogaol as a marker. Results: The suitable parameters of the 6-shogaol extraction process: Hot extraction using reflux equipment, solvent of 90% ethanol, solvent/herb ratio of ...
Ba Ngoc Minh Ho +3 more
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Objectives: To optimally extract the potential phytochemical “6-shogaol” from fermented shogaol-enriched ginger. Methods: Extraction process parameters were investigated using 6-shogaol as a marker. Results: The suitable parameters of the 6-shogaol extraction process: Hot extraction using reflux equipment, solvent of 90% ethanol, solvent/herb ratio of ...
Ba Ngoc Minh Ho +3 more
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Ginger (Gingerols and 6-Shogaol) Against Cancer
2021Ginger, the rhizomes of Zingiber officinale Roscoe (Zingiberaceae), is one of the most widely consumed spices worldwide due to its pungent smell and taste. It has also traditionally been used since antiquity for the treatment of ailments like common colds, fever, arthritis, rheumatism, gastrointestinal complications, motion sickness, diabetes ...
Esra Köngül Şafak +1 more
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