Results 81 to 90 of about 3,633 (207)
, 2012 4-Shogaol is one of the phytoconstituents isolated from dried red ginger, which is commercially available to consumers. Some active constituents from ginger have been found to have anti-inflammatory and antioxidant effects, but studies on 4-shogaol have ...
Ya-Ling Hsu;Chen, Chung-Yi;In-Pin Lin;Eing-Mei Tsai;Po-Lin Kuo;Ming-Feng Hou
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Food Science &Nutrition, Volume 14, Issue 7, July 2026.DSS exposure induces severe colitis, causing gut dysbiosis and mucosal inflammation driven by NF‐κB activation and spikes in pathogenic bacteria, TNF‐α, and IL‐6. However, “Mubong” Peel Extract effectively disrupts this inflammatory cascade. By suppressing NF‐κB‐dependent transcriptional activity, the extract mitigates clinical symptoms like colon ...
Awraris Derbie Assefa +4 more
wiley +1 more source
Vacuolization as a Novel Approach to Cancer Therapy
Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 6, June 2026.This review discusses the novel strategy of inducing vacuole formation in cancer cells using small molecules, that induce nonapoptotic cell death mechanisms, such as paraptosis, oncosis, autophagy, and methuosis, and its potential in overcoming resistance to apoptosis‐based cancer therapies.
Mariah Pasternak +9 more
wiley +1 more source
Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 6, June 2026.Diabetes mellitus causes significant damage to the male reproductive system. Sirt1/Nrf2/HO‐1 signaling pathway acts as a line of defense against ROS in reproductive organs. In STZ‐induced diabetic rats, the proapoptotic Bax protein expression was found to be elevated, whereas the antiapoptotic Bcl‐2 protein expression was reduced.
Edanur Güler Ekmen +3 more
wiley +1 more source
Desenvolvimento de miliesferas poliméricas de Quitosana/Alginato contendo [6]-shogaol [PDF]
Chitosan and sodium alginate are used in the production of modified drug-release millispheres. This technology can be used as an alternative to improve the therapeutic efficacy of active substances, such as [6]-shogaol, a natural product found in ginger ...
Passos, Mariana da Cruz
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Confirmation of the action of 6-shogaol on breast cancer spheroids.
, 2015 (A): Flow cytometric analysis of CD44+ /CD24- expression in untreated spheres (right upper panel) and spheres treated with 40 μM 6-shogaol for 18 hours (right lower panel).
Anasuya Ray (793851) +2 more
core +1 more source
Frontiers in PharmacologyBackgroundHepatocellular carcinoma currently has the third highest mortality rate in the world. Patients with hepatocellular carcinoma are on the rise and at a younger age, but research into the pharmacological effects of cancer is mostly single ...
Qiuxia Jin +5 more
doaj +1 more source
Radiotherapy is a powerful tumor therapeutic strategy for gastric cancer patients. However, radioresistance is a major obstacle to kill cancer cells.
Tae Woo Kim, Hee Gu Lee
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Molecular mechanism inhibiting human hepatocarcinoma cell invasion by 6-shogaol and 6-gingerol
, 2014 Scope: We previously demonstrated that 6-shogaol and 6-gingerol, two active compounds in ginger (Zingiber officinale), possess antiinvasive activity against highlymetastatic hepatoma cells.
Chou, Chai-Ping +3 more
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[6]-Shogaol Induces Ca2+ Signals by Activating the TRPV1 Channels in the Rat Insulinoma INS-1E Cells [PDF]
, 2014 Context [6]-shogaol is a vanilloid compound present in steamed ginger (Zingiber officinale), a commonly used spice. Pancreatic beta-cells respond to nutrients like glucose, amino acids and fatty acids, by an increase in the cytoplasmic free Ca2 ...
Islam, Md. Shahidul +3 more
core +1 more source