Results 71 to 80 of about 547,631 (352)

Roles of Short-Chain Fatty Acids in Inflammatory Bowel Disease

Nutrients, 2023
The gut microbiome is a diverse bacterial community in the human gastrointestinal tract that plays important roles in a variety of biological processes. Short-chain fatty acids (SCFA) are produced through fermentation of dietary fiber.
Yoonhwa Shin, Sunhee Han, Juhui Kwon, Songhyun Ju, T. Choi, I. Kang, Sung Soo Kim   +6 more
semanticscholar   +1 more source

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source

Short chain fatty acids: Microbial metabolites for gut-brain axis signalling.

Molecular and Cellular Endocrinology, 2022
The role of the intestinal microbiota as a regulator of gut-brain axis signalling has risen to prominence in recent years. Understanding the relationship between the gut microbiota, the metabolites it produces, and the brain will be critical for the ...
Kenneth J. O'Riordan, M. Collins, G. Moloney, Emily G. Knox, M. R. Aburto, C. Fülling, S. Morley, G. Clarke, H. Schellekens, J. Cryan   +9 more
semanticscholar   +1 more source

Randomised clinical study: inulin short-chain fatty acid esters for targeted delivery of short-chain fatty acids to the human colon [PDF]

, 2016
Summary Background Short-chain fatty acids (SCFA) produced through fermentation of nondigestible carbohydrates by the gut microbiota are associated with positive metabolic effects. However, well-controlled trials are limited in humans.
Amarri, Anderson, Andersson, Arpaia, Bach Knudsen, Berggren, Brown, Byrne, Canfora, Cani, Cani, Chambers, Chambers, Cherbut, Clarke, Cummings, Cummings, Das, Daud, Englyst, Freeland, Frost, Giusti, Jouet, Lin, Maurer, Molis, Morrison, Mossi, Nilsson, Nilsson, Nilsson, Nilsson, Nilsson, Parnell, Parrett, Poul, Pu, Robertson, Smith, So, Tolhurst, Topping, Trompette, Tuleu, Vadder, Wolever, Wright, Zeng   +48 more
core   +2 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Systemic availability and metabolism of colonic-derived short-chain fatty acids in healthy subjects: a stable isotope study [PDF]

, 2016
The short-chain fatty acids (SCFAs), acetate, propionate and butyrate, are bacterial metabolites that mediate the interaction between the diet, the microbiota and the host.
Annaert, Pieter, Boets, Eef, Courtin, Christophe M., De Preter, Vicky, De Vuyst, Luc, Delcour, Jan A., Deroover, Lise, Gomand, Sara V., Hamer, Henrike M., Preston, Tom, Van den Mooter, Guy, Verbeke, Kristin A., Vermeulen, Karen   +12 more
core   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

The role of short-chain fatty acids in inflammatory skin diseases

Frontiers in Microbiology, 2023
Short-chain fatty acids (SCFAs) are metabolites of gut microbes that can modulate the host inflammatory response, and contribute to health and homeostasis.
Xian-jun Xiao, Xiaoshen Hu, Junpeng Yao, Wei Cao, Zihao Zou, Luokai Wang, Hai-yan Qin, Dongling Zhong, Yuxi Li, Peiwen Xue, Rongjiang Jin, Ying Li, Yun-zhou Shi, Juan Li   +13 more
semanticscholar   +1 more source

Gut Microbiota as a Target for Food Allergy [PDF]

, 2016
Purpose of review: The purpose of this review is to present an overview on the potential role of gut microbiota as target of intervention against food allergy.
Amoroso, Antonio, BERNI CANANI, ROBERTO, DI COSTANZO, MARGHERITA   +2 more
core   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source