Results 51 to 60 of about 197,415 (263)

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Phospholipid and triglyceride metabolism of excised rat diaphragm and the role of these lipids in fatty acid uptake and oxidation*

Journal of Lipid Research, 1960
After a 48-hour fast, the phospholipid fatty acids of rat diaphragm are reduced much more than the triglyceride fatty acids. Phospholipid thus appears to contribute more to the labile fatty acids than triglyceride.
E.M. Neptune, Jr., H.C. Sudduth, D.R. Foreman, F.J. Fash   +3 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Effect of Fatty Acid Chain Length on Properties of Rice Starch-Fatty Acid Complexes

Shipin gongye ke-ji
Rice starch-fatty acid complexes were prepared by compounding rice starch with different chain lengths of lauric acid (C12), myristic acid (C14), and palmitic acid (C16). By measuring the composite index, gelatinization properties, rheological properties,
Jianhui JIA, Boxin DOU, Chujia ZHANG, Man GAO, Zhi ZHANG, Ying LIU, Na ZHANG   +6 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

The Impact of Short Chain Fatty Acids Derived from Gut Microbiota on Human Immune Function ——Analysis based on Bibliometrics

Liang you shipin ke-ji
The gut microbiota is closely related to human health, but mechanisms for the gut microbiota affects human health are not very clear. Short-chain fatty acids derived from the gut microbiota play an important role in immune regulation.
MIN Yu-ze, LIU Bin-wen, LIU Yu-qi, SONG Xiu-fang   +3 more
doaj   +1 more source

Glycerin Revalorization Using Anaerobic Digestion of Organic Waste

Chemical Engineering Transactions, 2013
A novel process for the revalorization of glycerine from biodiesel production is proposed. Glycerol is converted to short chain oils by reaction with volatile fatty acids. The volatile fatty acids can be obtained from anaerobic digestion of organic waste
A. Rafecas Rahuet, V. Plesu, J. Bonet Ruiz, A.E. Bonet Ruiz, J. Llorens Llacuna   +4 more
doaj   +1 more source

Diabetic wounds and short-chain fatty acids

Journal of Diabetes & Metabolic Disorders
Diabetes mellitus is a debilitating and worrisome chronic disease with many complications such as cardiovascular disease, kidney damage, blindness and diabetic wounds. Despite advances in the treatment of diabetic wounds, there are still concerns regarding the management of diabetic wound healing, particularly the inflammatory phase.
Zahra Rezaeiasl, Mahmoud Salami Zavareh
openaire   +2 more sources

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source