Mechanism study of tyrosine phosphatase shp-1 in inhibiting hepatocellular carcinoma progression by regulating the SHP2/GM-CSF pathway in TAMs [PDF]
Scientific ReportsHepatocellular carcinoma (HCC) is one of the most common malignant tumors worldwide. Macrophage-mediated innate immune responses play a crucial role in tumor development. This study revealed the mechanism of SHP-1 in regulating HCC progression.
Qiang Wei, ShuBin Luo, Gang He
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Treg-specific deletion of the phosphatase SHP-1 impairs control of inflammation in vivo [PDF]
Frontiers in Immunology, 2023 IntroductionTo achieve a healthy and functional immune system, a delicate balance exists between the activation of conventional T cells (Tcon cells) and the suppression by regulatory T cells (Treg). The tyrosine phosphatase SHP-1, a negative regulator of
QinLei Gu +6 more
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Targeting pathogenic macrophages by the application of SHP-1 agonists reduces inflammation and alleviates pulmonary fibrosis [PDF]
Cell Death and Disease, 2023 Idiopathic pulmonary fibrosis is a progressive fibrotic disorder with no cure that is characterized by deterioration of lung function. Current FDA-approved drugs for IPF delay the decline in lung function, but neither reverse fibrosis nor significantly ...
Shiao-Ya Hong +6 more
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Consideration of SHP-1 as a Molecular Target for Tumor Therapy. [PDF]
Int J Mol Sci, 2023 Abnormal activation of receptor tyrosine kinases (RTKs) contributes to tumorigenesis, while protein tyrosine phosphatases (PTPs) contribute to tumor control. One of the most representative PTPs is Src homology region 2 (SH2) domain-containing phosphatase 1 (SHP-1), which is associated with either an increased or decreased survival rate depending on the
Lim S, Lee KW, Kim JY, Kim KD.
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SHP-1 acts as a tumor suppressor by interacting with EGFR and predicts the prognosis of human breast cancer [PDF]
Cancer Biology & Medicine, 2022 Objective: The aims of this study were to examine the prognostic value of SHP-1 in breast cancer, its roles in the regulation of breast cancer cell growth and metastasis, and the underlying mechanisms.
Qian Geng +4 more
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SHP-1 Promotes the Replication of Porcine Epidemic Diarrhea Virus by Inhibiting TRAF3-Mediated Type I Interferon Immune Responses [PDF]
PathogensPorcine epidemic diarrhea virus (PEDV), a member of the genus Alpha coronavirus, is one of the main pathogens causing piglet diarrhea. PEDV can enhance its replication by regulating host protein function.
Jiaqing Hu +4 more
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Inhibition of SHP-1 activity by PKC-θ regulates NK cell activation threshold and cytotoxicity [PDF]
eLife, 2022 Natural killer (NK) cells play a crucial role in immunity, killing virally infected and cancerous cells. The balance of signals initiated upon engagement of activating and inhibitory NK receptors with cognate ligands determines killing or tolerance ...
Aviad Ben-Shmuel +11 more
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SHP-1 mediates cigarette smoke extract-induced epithelial–mesenchymal transformation and inflammation in 16HBE cells [PDF]
Open MedicineSrc-homology region 2 domain-containing phosphatase 1 (SHP-1) is considered an anti-inflammatory factor, but its role in chronic obstructive pulmonary disease (COPD) remains unknown.
He Quan +6 more
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Regulation of PPARγ2 Stability and Activity by SHP-1. [PDF]
Mol Cell BiolThe protein tyrosine phosphatase Src homology region 2 domain-containing phosphatase-1 (SHP-1) plays an important role in modulating glucose and lipid homeostasis. We previously suggested a potential role of SHP-1 in the regulation of peroxisome proliferator-activated receptor γ2 (PPARγ2) expression and activity but the mechanisms were unexplored ...
Kumar A +9 more
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Reduced Tyk2/SHP-1 interaction and lack of SHP-1 mutation in a kindred of familial hemophagocytic lymphohistiocytosis [PDF]
Leukemia, 1998 Familial hemophagocytic lymphohistiocytosis (FHLH) is an autosomal recessive disease with features similar to those of the murine motheaten phenotype resulting from mutations of protein tyrosine phosphatase SHP-1. This has raised the possibility that defects in SHP-1 or SHP-1-regulated signaling molecules may be present in FHLH.
Maurizio Arico', T Yi
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