Results 11 to 20 of about 10,714 (176)
Functions of Shp2 in cancer [PDF]
Journal of Cellular and Molecular Medicine, 2015 AbstractDiagnostics and therapies have shown evident advances. Tumour surgery, chemotherapy and radiotherapy are the main techniques in treat cancers. Targeted therapy and drug resistance are the main focus in cancer research, but many molecular intracellular mechanisms remain unknown.
Zhang, Jie, Zhang, Fei, Niu, Ruifang
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Hepatology, EarlyView., 2022 KAT7‐acetylated and cytoplasm‐translocated G‐protein GαS enhances IL‐6 effect and drives HCC progenitor cell progression. Abstract Background and Aims Hepatocarcinogenesis goes through HCC progenitor cells (HcPCs) to fully established HCC, and the mechanisms driving the development of HcPCs are still largely unknown.
Ye Zhou +15 more
wiley +1 more source
SHP2 blockade enhances anti-tumor immunity via tumor cell intrinsic and extrinsic mechanisms
Scientific Reports, 2021 SHP2 is a ubiquitous tyrosine phosphatase involved in regulating both tumor and immune cell signaling. In this study, we discovered a novel immune modulatory function of SHP2.
Ye Wang +47 more
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Frontiers in Cell and Developmental Biology, 2021 Gain-of-function mutation of SHP2 is a central regulator in tumorigenesis and cancer progression through cell-autonomous mechanisms. Activating mutation of SHP2 in microenvironment was identified to promote cancerous transformation of hematopoietic stem ...
Lei Dong +5 more
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Thoracic Cancer, 2021 Background Src homology region 2 domain‐containing phosphatase 2 (SHP2) is a novel target for Kirsten rat sarcoma oncogene (KRAS) mutant cancer. We retrospectively studied the significance of SHP2 in KRAS mutant non‐small cell lung cancer (NSCLC) treated
Hui‐Bo Feng +19 more
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High expression of SHP2 predicts a promising prognosis in colorectal cancer
Indian Journal of Pathology and Microbiology, 2023 Background: Src homology 2 domain-containing phosphatase 2 (SHP2) is hyper-activated in some solid tumors. Previous findings suggest that the expression of SHP2 in colorectal cancer (CRC) may be associated with prognosis.
Xibo Liu +5 more
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Targeting the SHP2 phosphatase promotes vascular damage and inhibition of tumor growth
EMBO Molecular Medicine, 2021 The tyrosine phosphatase SHP2 is oncogenic in cancers driven by receptor‐tyrosine‐kinases, and SHP2 inhibition reduces tumor growth. Here, we report that SHP2 is an essential promoter of endothelial cell survival and growth in the remodeling tumor ...
Yuyi Wang +11 more
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Frontiers in Cell and Developmental Biology, 2021 Osteoarthritis (OA) is a chronic articular disease characterized by cartilage degradation, subchondral bone remodeling and osteophyte formation. Src homology 2 domain-containing protein tyrosine phosphatase (SHP2) has not been fully investigated in the ...
Tenghui Tao +10 more
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Experimental Hematology & Oncology, 2023 Leukemogenic SHP2 mutations occur in 35% of patients with juvenile myelomonocytic leukemia (JMML), a rare but fatal hematopoietic malignancy without representative cell models, which are urgently needed to investigate the pathogenesis and to develop ...
Yuming Zhao +9 more
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Role of SHP2 in hematopoiesis and leukemogenesis [PDF]
Current Opinion in Hematology, 2017 Purpose of review SH2 domain-containing tyrosine phosphatase 2 (SHP2), encoded by PTPN11 plays an important role in regulating signaling from cell surface receptor tyrosine kinases during normal development as well as oncogenesis. Herein we review recently discovered roles of SHP2 in normal and aberrant hematopoiesis along with
Pandey, Ruchi +2 more
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