Results 31 to 40 of about 10,714 (176)

Protein tyrosine phosphatase Shp2 deficiency in podocytes attenuates lipopolysaccharide-induced proteinuria

Scientific Reports, 2017
Podocytes are specialized epithelial cells that play a significant role in maintaining the integrity of the glomerular filtration barrier and preventing urinary protein leakage.
Ming-Fo Hsu, Ahmed Bettaieb, Yoshihiro Ito, James Graham, Peter J. Havel, Fawaz G. Haj   +5 more
doaj   +1 more source

An In Silico Study Investigating Camptothecin-Analog Interaction with Human Protein Tyrosine Phosphatase, SHP2 (PTPN11)

Pharmaceuticals, 2023
The human PTPN11 gene encodes for the src tyrosine phosphatase protein (SHP2) is now gaining much attention in many disorders, particularly its oncogenic involvement in many types of cancer.
Donald Bajia, Katarzyna Derwich
doaj   +1 more source

Sticking It to Cancer with Molecular Glue for SHP2 [PDF]

Cancer Cell, 2016
Much effort has been expended to develop inhibitors against protein-tyrosine phosphatases (PTPs), nearly all of it unsuccessful. A recent report, describing a highly specific, orally bioavailable inhibitor of the PTP oncoprotein SHP2 with in vivo activity, suggests that allostery might provide a way forward for PTP inhibitor development.
Hao, Ran, Ryouhei, Tsutsumi, Toshiyuki, Araki, Benjamin G, Neel   +3 more
openaire   +2 more sources

Therapeutic Suppression of FAK-AKT Signaling Overcomes Resistance to SHP2 Inhibition in Colorectal Carcinoma

Frontiers in Pharmacology, 2021
SHP2 mediates signaling from multiple receptor tyrosine kinases (RTKs) to extracellular signal-regulated kinase (ERK) and Ser and Thr kinase AKT, and its inhibitors offer an unprecedented opportunity for cancer treatment.
Ye Li, Ye Li, Yuncang Yuan, Fan Zhang, Aizhen Guo, Fuao Cao, Mengmeng Song, Yating Fu, Xiaowen Xu, Hao Shen, Shangyong Zheng, Yamin Pan, Wenjun Chang   +12 more
doaj   +1 more source

Tumoral IL-10-activated SHP2 in macrophages promotes mammary carcinoma progression

Fundamental Research
The Src homology 2 domain-containing tyrosine phosphatase 2 (SHP2) is a non-receptor tyrosine phosphatase and acts as a convergent node for oncogenic cell-signaling cascades.
Jian Gao, Zhixiu Chen, Yixuan Wang, Lele Guo, Minmin Fan, Lin Zhou, Liwei Wang, Ying Huang, Yang Sun, Wenjie Guo, Yan Shen, Qiang Xu   +11 more
doaj   +1 more source

Molecular features underlying differential SHP1/SHP2 binding of immune checkpoint receptors

eLife, 2021
A large number of inhibitory receptors recruit SHP1 and/or SHP2, tandem-SH2-containing phosphatases through phosphotyrosine-based motifs immunoreceptor tyrosine-based inhibitory motif (ITIM) and immunoreceptor tyrosine-based switch motif (ITSM).
Xiaozheng Xu, Takeya Masubuchi, Qixu Cai, Yunlong Zhao, Enfu Hui   +4 more
doaj   +1 more source

Targeting SHP2 phosphatase in hematological malignancies

Expert Opinion on Therapeutic Targets, 2022
Src homology-2-containing protein tyrosine phosphatase 2 (SHP2) is a ubiquitously expressed, non-receptor protein tyrosine phosphatase encoded by the PTPN11 gene. Gain-of-function (GOF) mutations in PTPN11 are associated with the development of various hematological malignancies and Noonan syndrome with multiple lentigines (NS-ML).
Kanumuri, Rahul, Pasupuleti, Santhosh Kumar, Burns, Sarah S., Ramdas, Baskar, Kapur, Reuben   +4 more
openaire   +2 more sources

SH2 Domain-Containing Phosphatase-SHP2 Attenuates Fibrotic Responses through Negative Regulation of Mitochondrial Metabolism in Lung Fibroblasts

Diagnostics, 2023
Background: We have previously shown that SHP2 downregulation may predispose fibroblasts to differentiate into myofibroblasts and proposed a role for SHP2 downregulation in the pathogenesis of idiopathic pulmonary fibrosis (IPF).
Theodoros Karampitsakos, Apostolos Galaris, Ilianna Barbayianni, Giuseppe DeIuliis, Farida Ahangari, Fotis Sampsonas, Vasilina Sotiropoulou, Vassilis Aidinis, Anton M. Bennett, Jose D. Herazo-Maya, Nikolaos Xylourgidis, Petros Bakakos, Demosthenes Bouros, Naftali Kaminski, Argyrios Tzouvelekis   +14 more
doaj   +1 more source

Targeting endogenous proteins for degradation through the affinity-directed protein missile system [PDF]

Open Biology, 2017
Targeted proteolysis of endogenous proteins is desirable as a research toolkit and in therapeutics. CRISPR/Cas9-mediated gene knockouts are irreversible and often not feasible for many genes.
Luke J. Fulcher, Luke D. Hutchinson, Thomas J. Macartney, Craig Turnbull, Gopal P. Sapkota   +4 more
doaj   +1 more source

Allosteric inhibition reveals SHP2-mediated tumor immunosuppression in colon cancer by single-cell transcriptomics

Acta Pharmaceutica Sinica B, 2022
Colorectal cancer (CRC), a malignant tumor worldwide consists of microsatellite instability (MSI) and stable (MSS) phenotypes. Although SHP2 is a hopeful target for cancer therapy, its relationship with innate immunosuppression remains elusive.
Jian Gao, Zhigui Wu, Mingxia Zhao, Rui Zhang, Manru Li, Dongdong Sun, Haibo Cheng, Xianjia Qi, Yuxian Shen, Qiang Xu, Hongqi Chen, Dijun Chen, Yang Sun   +12 more
doaj   +1 more source