Results 21 to 30 of about 10,714 (176)

SHP2 Nuclear/Cytoplasmic Trafficking in Granulosa Cells Is Essential for Oocyte Meiotic Resumption and Maturation

Frontiers in Cell and Developmental Biology, 2021
Src-homology-2-containing phosphotyrosine phosphatase (SHP2), a classic cytoplasmic protein and a major regulator of receptor tyrosine kinases and G protein-coupled receptors, plays a significant role in preimplantation embryo development. In this study,
Muhammad Idrees, Vikas Kumar, Myeong-Don Joo, Niaz Ali, Keun-Woo Lee, Il-Keun Kong, Il-Keun Kong   +6 more
doaj   +1 more source

Src-Homology 2 Domain-Containing Phosphatase 2 in Resected EGFR Mutation-Positive Lung Adenocarcinoma

JTO Clinical and Research Reports, 2020
Introduction: EGFR mutation-positive lung adenocarcinoma (LUAD) displays impaired phosphorylation of ERK and Src-homology 2 domain-containing phosphatase 2 (SHP2) in comparison with EGFR wild-type LUADs.
Masaoki Ito, MD, Jordi Codony-Servat, PhD, Ana Giménez-Capitán, BSc, Mireia Serra-Mitjans, MD, Francisco Pérez-Ochoa, MD, David Llige, BSc, Imane Chaib, PhD, Ramón Rami-Porta, MD, Carme Obiols, MD, Sergi Call, MD, Manuela Iglesias, MD, José Belda-Sanchis, MD, Xavier Tarroch-Sarasa, MD, Niki Karachaliou, MD, Miguel Angel Molina-Vila, PhD, Morihito Okada, MD, Rafael Rosell, MD   +16 more
doaj   +1 more source

Tyrosine phosphatase Shp2 mediates the estrogen biological action in breast cancer via interaction with the estrogen extranuclear receptor. [PDF]

PLoS ONE, 2014
The extranuclear estrogen receptor pathway opens up novel perspectives in many physiological and pathological processes, especially in breast carcinogenesis. However, its function and mechanisms are not fully understood.
Jun Li, Yujia Kang, Longgang Wei, Wenjie Liu, Yingpu Tian, Baozhen Chen, Xiandong Lin, Yang Li, Gen-Sheng Feng, Zhongxian Lu   +9 more
doaj   +1 more source

SHP2 promotes proliferation of breast cancer cells through regulating Cyclin D1 stability via the PI3K/AKT/GSK3β signaling pathway

Cancer Biology & Medicine, 2020
Objective: The tyrosine phosphatase SHP2 has a dual role in cancer initiation and progression in a tissue type-dependent manner. Several studies have linked SHP2 to the aggressive behavior of breast cancer cells and poorer outcomes in people with cancer.
Yue Yuan*, Yanling Fan*, Zicong Gao, Xuan Sun, He Zhang, Zhiyong Wang, Yanfen Cui, Weijie Song, Zhaosong Wang, Fei Zhang, Ruifang Niu   +10 more
doaj   +1 more source

HSP70 binds to SHP2 and has effects on the SHP2-related EGFR/GAB1 signaling pathway [PDF]

Biochemical and Biophysical Research Communications, 2006
The Src homology phosphotyrosyl phosphatase, SHP2, is a positive effector of EGFR signaling. However, the molecular mechanism and biological functions of SHP2 regulation are still not completely known. To better understand the cellular processes in which SHP2 participates, we carried out mass spectrometry to find SHP2 binding proteins.
Jae Cheal, Yoo, Michael J, Hayman
openaire   +2 more sources

A conserved mechanism for control of human and mouse embryonic stem cell pluripotency and differentiation by shp2 tyrosine phosphatase. [PDF]

PLoS ONE, 2009
Recent studies have suggested distinctive biological properties and signaling mechanisms between human and mouse embryonic stem cells (hESCs and mESCs). Herein we report that Shp2, a protein tyrosine phosphatase with two SH2 domains, has a conserved role
Dongmei Wu, Yuhong Pang, Yuehai Ke, Jianxiu Yu, Zhao He, Lutz Tautz, Tomas Mustelin, Sheng Ding, Ziwei Huang, Gen-Sheng Feng   +9 more
doaj   +1 more source

Discovery of a SHP2 Degrader with In Vivo Anti-Tumor Activity

Molecules, 2023
Src homology 2 domain-containing phosphatase 2 (SHP2) is an attractive target for cancer therapy due to its multifaceted roles in both tumor and immune cells.
Jinmin Miao, Yunpeng Bai, Yiming Miao, Zihan Qu, Jiajun Dong, Ruo-Yu Zhang, Devesh Aggarwal, Brenson A. Jassim, Quyen Nguyen, Zhong-Yin Zhang   +9 more
doaj   +1 more source

Targeted Degradation of the Oncogenic Phosphatase SHP2

Biochemistry, 2021
SHP2 is a protein tyrosine phosphatase that plays a critical role in the full activation of the Ras-MAPK pathway upon stimulation of receptor tyrosine kinases, which are frequently amplified or mutationally activated in human cancer. In addition, activating mutations in SHP2 result in developmental disorders and hematologic malignancies.
Vidyasiri Vemulapalli, Katherine A. Donovan, Tom C. M. Seegar, Julia M. Rogers, Munhyung Bae, Ryan J. Lumpkin, Ruili Cao, Matthew T. Henke, Soumya S. Ray, Eric S. Fischer, Gregory D. Cuny, Stephen C. Blacklow   +11 more
openaire   +3 more sources

SHP2 allosteric inhibitor TK-453 alleviates psoriasis-like skin inflammation in mice via inhibition of IL-23/Th17 axis

iScience, 2022
Summary: SHP2 is the first oncogenic tyrosine phosphatase encoded by PTPN11, which plays a significant regulatory role in cancer and inflammation-related diseases. Although SHP2 allosteric inhibitors have been used in phase I/II clinical trials for solid
Meijing Wang, Tinghan Li, Zijun Ouyang, Kai Tang, Yuyu Zhu, Chenglin Song, Haiyan Sun, Bin Yu, Xiaoyun Ji, Yang Sun   +9 more
doaj   +1 more source

SHP2 Is a Target of the Immunosuppressant Tautomycetin

Chemistry & Biology, 2011
SHP2 phosphatase is a positive transducer of growth factor and cytokine signaling. SHP2 is also a bona fide oncogene; gain-of-function SHP2 mutations leading to increased phosphatase activity cause Noonan syndrome, as well as multiple forms of leukemia and solid tumors.
Liu, Sijiu, Yu, Zhihong, Yu, Xiao, Huang, Sheng-Xiong, Luo, Yinggang, Wu, Li, Shen, Weihua, Yang, Zhenyun, Wang, Lina, Gunawan, Andrea M., Chan, Rebecca J., Shen, Ben, Zhang, Zhong-Yin   +12 more
openaire   +2 more sources