Results 11 to 20 of about 10,969 (212)

Multidrug-resistant Klebsiella pneumoniae harboring extended spectrum β-lactamase encoding genes isolated from human septicemias.

PLoS ONE, 2021
Klebsiella pneumoniae is a major pathogen implicated in nosocomial infections. Extended-spectrum β-lactamase (ESBL)-producing K. pneumoniae isolates are a public health concern.
Isabel Carvalho, Nadia Safia Chenouf, José António Carvalho, Ana Paula Castro, Vanessa Silva, Rosa Capita, Carlos Alonso-Calleja, Maria de Lurdes Nunes Enes Dapkevicius, Gilberto Igrejas, Carmen Torres, Patrícia Poeta   +10 more
doaj   +1 more source

Characterization of ESBL-Producing Escherichia coli and Klebsiella pneumoniae Isolated from Clinical Samples in a Northern Portuguese Hospital: Predominance of CTX-M-15 and High Genetic Diversity

Microorganisms, 2021
Background: Enterobacteriaceae are major players in the spread of resistance to β-lactam antibiotics through the action of CTX-M β-lactamases. We aimed to analyze the diversity and genetic characteristics of ESBL-producing Escherichia coli and Klebsiella
Isabel Carvalho, José António Carvalho, Sandra Martínez-Álvarez, Madjid Sadi, Rosa Capita, Carlos Alonso-Calleja, Fazle Rabbi, Maria de Lurdes Nunes Enes Dapkevicius, Gilberto Igrejas, Carmen Torres, Patrícia Poeta   +10 more
doaj   +1 more source

Epidemiological characteristics of SHV, cmlv, and FosA6-producing carbapenem-resistant Klebsiella pneumoniae based on whole genome sequences in Jiangsu, China

Frontiers in Microbiology, 2023
Carbapenem-resistant Klebsiella pneumoniae (CRKP), particularly those with high virulence, cause invasive disease in clinical settings. An epidemiological investigation was conducted on the evolution, virulence, and antimicrobial resistance of CRKP ...
Jiaying Zhu, Jiaying Zhu, Yanmin Ju, Xinyu Zhou, Taoyu Chen, Xiangkai Zhuge, Jianjun Dai, Jianjun Dai   +7 more
doaj   +1 more source

Why the Extended-Spectrum β-Lactamases SHV-2 and SHV-5 Are “Hypersusceptible” to Mechanism-Based Inhibitors [PDF]

Biochemistry, 2009
Extended-spectrum beta-lactamases (ESBLs) are derivatives of enzymes such as SHV-1 and TEM-1 that have undergone site-specific mutations that enable them to hydrolyze, and thus inactivate, oxyimino-cephalosporins, such as cefotaxime and ceftazidime.
Matthew, Kalp, Christopher R, Bethel, Robert A, Bonomo, Paul R, Carey   +3 more
openaire   +2 more sources

Identification and characterization of colistin-resistant E. coli and K. pneumoniae isolated from Lower Himalayan Region of India

SN Applied Sciences, 2021
Multidrug resistance is one of the worldwide public health concerns. Water represents the most suitable environment, for the exchange of antibiotic resistance genes among pathogenic to non-pathogenic bacteria.
Avinash Singh, Anand Kumar Keshri, Suraj Singh Rawat, Deepak Swami, Kala Venkata Uday, Amit Prasad   +5 more
doaj   +1 more source

Characterization of a P1-Like Bacteriophage Carrying an SHV-2 Extended-Spectrum β-Lactamase from an Escherichia coli Strain [PDF]

Antimicrobial Agents and Chemotherapy, 2014
ABSTRACT P1 bacteriophages lysogenize bacteria as independent plasmid-like elements. We describe here a P1-like bacteriophage, RCS47, carrying a bla SHV-2 gene, isolated from a clinical strain of Escherichia coli from phylogroup B1, and we report the prevalence of P1 ...
Billard-Pomares, Typhaine, Fouteau, Stéphanie, Jacquet, Marie, Roche, David, Barbe, Valérie, Castellanos, Miguel, Bouet, Jean, Cruveiller, Stéphane, Médigue, Claudine, Blanco, Jorge, Clermont, Olivier, Denamur, Erick, Branger, Catherine   +12 more
openaire   +4 more sources

A High Resolution DNA Melting Curve Analysis for the Rapid and Efficient Molecular Diagnostics of Extended Spectrum β-Lactamase Determinants from Foodborne Escherichia coli

Microorganisms, 2020
The accurate identification of Extended-Spectrum β-Lactamase (ESBL) genes in Gram-negative bacteria is necessary for surveillance and epidemiological studies of transmission through foods.
Patrick Murigu Kamau Njage, Elna Buys
doaj   +1 more source

Broad-spectrum β-lactamases among Enterobacteriaceae of animal origin: molecular aspects, mobility and impact on public health [PDF]

, 2010
Broad-spectrum β-lactamase genes (coding for extended-spectrum β-lactamases (ESBLs) and AmpC β-lactamases) have been frequently demonstrated in the microbiota of food-producing animals. This may pose a human health hazard since these genes may be present
Butaye, Patrick, Dewulf, Jeroen, Haesebrouck, Freddy, Herman, Lieve, Heyndrickx, Marc, Martel, An, Persoons, Davy, Smet, Annemieke   +7 more
core   +1 more source

Different promoters of SHV-2 and SHV-2a  -lactamase lead to diverse levels of cefotaxime resistance in their bacterial producers [PDF]

Journal of General Microbiology, 1991
Clinical Klebsiella pneumoniae isolates as well as Escherichia coli transformants producing the beta-lactamases SHV-2 or SHV-2a demonstrate MIC values for cefotaxime of 4 mg l-1 or 64 to greater than 128 mg l-1, respectively. The beta-lactamases differ by one possibly insignificant amino acid exchange at position number 10 of the mature protein; their ...
A, Podbielski, J, Schönling, B, Melzer, G, Haase   +3 more
openaire   +2 more sources

Genomic Insights into Pluralibacter gergoviae Sheds Light on Emergence of a Multidrug-Resistant Species Circulating between Clinical and Environmental Settings

Pathogens, 2023
Pluralibacter gergoviae is a member of the Enterobacteriaceae family that has been reported sporadically. Although P. gergoviae strains exhibiting multidrug-resistant profiles have been identified an in-depth genomic analysis focusing on antimicrobial ...
João Pedro Rueda Furlan, Eliana Guedes Stehling   +1 more
doaj   +1 more source