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Tn and Sialyl-Tn Antigens as Potential Prognostic Markers in Human Ovarian Carcinoma
Gynecologic and Obstetric Investigation, 2010Objective: Carcinoma-associated Tn and sialyl-Tn antigens have been shown to aid in the prediction of tumor aggressiveness. The purpose of this study was to evaluate the prognostic value of Tn and sialyl-Tn antigen expression in human ovarian carcinoma.
H, Ogawa, M, Ghazizadeh, T, Araki
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Sialyl-Tn antigen as a useful predictor of poor prognosis in patients with advanced stomach cancer
Surgery Today, 1998Sialyl-Tn antigen (STn) expression was studied immunohistochemically in 211 primary advanced gastric carcinomas. The overall rate of positive STn staining was 17% (35/211), and positive STn staining was found not to be correlated with tumor size, depth of invasion, lymph node metastasis, liver metastasis, or peritoneal metastasis.
S, Terashima +6 more
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Correlation of serum sialyl Tn antigen values determined by immunoassay and SRM based method
Analytical Biochemistry, 2018We previously identified four glycan tumor marker candidates using a HPLC-based method. One candidate was sialyl Tn (STN), NeuAcα2-6-GalNAc. In this study, glycans were prepared from sera by hydrazine treatment followed by fluorescent labeling with aminopyridine.
Miki, Tanaka-Okamoto +5 more
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Pediatric Pathology & Molecular Medicine, 2003
Sialyl-Tn antigen (STn) is a mucin-type carbohydrate normally present in goblet cells of small and large bowel. STn expression has been demonstrated to occur in complete and incomplete intestinal metaplasia as well as in many carcinomas but in no normal gastric cell.
Marta, Cohen +2 more
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Sialyl-Tn antigen (STn) is a mucin-type carbohydrate normally present in goblet cells of small and large bowel. STn expression has been demonstrated to occur in complete and incomplete intestinal metaplasia as well as in many carcinomas but in no normal gastric cell.
Marta, Cohen +2 more
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[Heterogeneity of the CA125 antigen that coexpresses sialyl Tn and CA19-9 antigens].
Nihon Sanka Fujinka Gakkai zasshi, 1993High molecular mass glycoproteins detected by the monoclonal antibody OC125 were found in secreted and solubilized materials from the ovarian cancer cell line, HOC-I. The CA125 antigen has been isolated from HOC-I cell extract and conditioned media by perchloric acid precipitation, gel filtration, and OC125 affinity purification.
H, Kobayashi +3 more
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Journal of Cutaneous Pathology, 1999
Keratoacanthoma and squamous cell carcinoma are common skin tumors, especially in immunosuppressed transplant recipients, but the distinction between these two types of epidermal neoplasia may be difficult. Sialyl‐Tn (Sia‐GalNAc‐O‐Ser/Thr) is a cell surface carbohydrate associated with hyperplasia in squamous epithelium, and correlated with poor ...
P, Jensen, O P, Clausen, M, Bryne
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Keratoacanthoma and squamous cell carcinoma are common skin tumors, especially in immunosuppressed transplant recipients, but the distinction between these two types of epidermal neoplasia may be difficult. Sialyl‐Tn (Sia‐GalNAc‐O‐Ser/Thr) is a cell surface carbohydrate associated with hyperplasia in squamous epithelium, and correlated with poor ...
P, Jensen, O P, Clausen, M, Bryne
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International Journal of Gynecological Cancer, 2012
Although CA125 antigen is a useful marker for ovarian cancer, its expression is also elevated in endometriosis. The purpose of this study was to develop an assay method for evaluating differentially glycosylated MUC16 (CA125 core protein) in patients with endometriosis and ovarian cancer.We prepared MUC16-enriched fractions from peritoneal fluid of ...
Kaoru, Akita +9 more
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Although CA125 antigen is a useful marker for ovarian cancer, its expression is also elevated in endometriosis. The purpose of this study was to develop an assay method for evaluating differentially glycosylated MUC16 (CA125 core protein) in patients with endometriosis and ovarian cancer.We prepared MUC16-enriched fractions from peritoneal fluid of ...
Kaoru, Akita +9 more
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Sialyl-Tn antigen expression and O-linked GalNAc-Thr synthesis by Trypanosoma cruzi
Biochemical and Biophysical Research Communications, 2003Most Trypanosoma cruzi O-glycans are linked to Thr/Ser residues via N-acetylglucosamine. We report that the mucin-type carcinoma-associated sialyl-Tn antigen (NeuAc-GalNAc-O-Ser/Thr) is expressed by T. cruzi. A specific MAb allowed us to localize the antigen on the surface of epimastigotes and to identify reactive components in parasite lysates (32, 60,
Teresa, Freire +4 more
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Clinical value of sialyl Tn antigen in patients with gynecologic tumors.
Obstetrics and gynecology, 1990Sialyl Tn antigen was measured by the immunoradiometric competitive inhibition assay in sera from patients with various gynecologic tumors: 49 uterine myomas, 97 cervical cancers, 42 endometrial cancers, 63 benign ovarian tumors, and 59 ovarian cancers including eight cases of borderline malignancy.
M, Inoue +5 more
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Role of Sialyl-Tn Antigen in Cancer Metastasis
2023Ruka Ito, Keisuke Nagao, Kazuaki Ohtsubo
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