, 2017 Key words: Sialyl Tn, drug resistance, antibody-drug conjugates, cancer stem cells OBJECTIVES: A successful therapeutic strategy for ovarian cancer will require direct targeting of inherently chemoresistant tumor cells which are comprised ...
D. Eavarone +6 more
core +1 more source
Association of Sialyl Tn antigen with cervical cancer lymph node status: An NRG oncology/GOG study. [PDF]
Gynecol Oncol, 2023 Benbrook DM +12 more
europepmc +1 more source
Mucin-type sialyl-Tn antigen is associated with PD-L1 expression and predicts poor clinical prognosis in breast cancer. [PDF]
Gland Surg, 2021 Xu F, Zhao H, Li J, Jiang H.
europepmc +1 more source
Siglec-15 recognition of sialoglycans on tumor cell lines can occur independently of sialyl Tn antigen expression. [PDF]
Glycobiology, 2021 Murugesan G +11 more
europepmc +1 more source
Simple mucin-type carbohydrate antigens (T, sialosyl T, Tn and sialosyl-Tn) in breast carcinogenesis
, 1995 Immunohistochemical analysis of the expression of simple mucin-type carbohydrate antigens (Tn, sialyl-Tn and T) was performed in a series of 43 cases of intraductal hyperplasia without atypia, 9 cases of intraductal hyperplasia with atypia, 54 cases of ...
Lacerda, M. [UNESP] +5 more
core +1 more source
PLoS ONEColorectal cancer (CRC) has become a significant global health concern and ranks among the leading causes of morbidity and mortality worldwide. Due to its malignant nature, current immunotherapeutic treatments are used to tackle this issue.
Mohammed Saqif Ahmad +2 more
doaj +1 more source
, 2005 Sialyl-Tn is a carbohydrate antigen overexpressed in several epithelial cancers including breast cancer, and usually associated with poor prognosis. Sialyl-Tn is synthesized by a CMP-Neu5Ac: GalNAc alpha2,6-sialyltransferase: ST6GalNAc I, which catalyzes
Krzewinski-Recchi, Marie-Ange +5 more
core
Preoperative Serum Levels of Sialyl Lewisa, Sialyl Lewisx, and Carcinoembryonic Antigens as Prognostic Factors after Resection for Primary Breast Cancer [PDF]
, 2002 Sialyl Lewisa (CA19-9) and sialyl LewisX antigens (CSLEXI) may play a role in tumor metastasis by serving as functional ligands in the cell adhesion system. To determine their prognostic value, we examined preoperative serum levels of CA19-9, CSLEXI, and
Itoyanagi, Noriaki +7 more
core
Suppression of core 1 Gal-transferase is associated with reduction of TF and reciprocal increase of Tn, sialyl-Tn and Core 3 glycans in human colon cancer cells. [PDF]
, 2013 It has long been presumed, though with surprisingly little evidence, a competition between Core 1 Gal-transferase (C1GalT), Core 3 GlcNAc-transferase (C3GnT) and sialyl-transferase (ST6GalNAc-T) for elongation of O-linked mucin-type glycans initiated ...
Lu-Gang Yu +4 more
core +1 more source
, 2004 The Sialyl-Tn antigen (Neu5Acalpha2-6GaINAc-O-Ser/Thr) is highly expressed in several human carcinomas and is associated with carcinoma aggressiveness and poor prognosis.
Harduin-Lepers, Anne +12 more
core