Results 51 to 60 of about 542,634 (177)

Differential expression of CD175 and CA19-9 in pancreatic adenocarcinoma

Scientific Reports
Alterations in protein glycosylation are observed in many solid tumor types leading to formation of tumor-associated carbohydrate antigens (TACAs). The most common TACA is the Tn antigen (CD175), which is a mucin-type O-GalNAc-Ser/Thr/Tyr glycan in ...
Jane J. Cheng, Yasuyuki Matsumoto, Gabrielle E. Dombek, Kathryn A. Stackhouse, Ana Sofia Ore, Jonathan N. Glickman, Jamie Heimburg-Molinaro, Richard D. Cummings   +7 more
doaj   +1 more source

Protein glycosylation in lung cancer from a mass spectrometry perspective

Mass Spectrometry Reviews, Volume 45, Issue 3, Page 455-475, May/June 2026.
ABSTRACT Lung cancer is a severe disease for which better diagnostic and therapeutic approaches are urgently needed. Increasing evidence implies that aberrant protein glycosylation plays a crucial role in the pathogenesis and progression of lung cancer.
Mirjam Balbisi, Simon Sugár, Lilla Turiák   +2 more
wiley   +1 more source

Chemobacterial Synthesis of a Sialyl-Tn Cyclopeptide Vaccine Candidate.

, 2017
International audienceA conjugatable form of the tumour-associated carbohydrate antigen sialyl-Tn (Neu5Ac-α-2,6-GalNAc) was efficiently produced in Escherichia coli. Metabolically engineered E.
Richard, Emeline, Priem, Bernard, Pifferi, Carlo, Fort, Sébastien, Le Gouellec, Audrey, Emeline Richard, Eric Samain, Sébastien Fort, Carlo Pifferi, Samain, Eric, Fiore, Michele, Renaudet, Olivier, Michele Fiore, Audrey Le Gouëllec, Olivier Renaudet, Bernard Priem   +15 more
core   +1 more source

A Case of Anti‐AMY1‐Positive Lung Squamous Cell Carcinoma With Severe Hyperamylasemia Linked to Disease Progression

Respirology Case Reports, Volume 14, Issue 5, May 2026.
We present a case of anti‐AMY1‐positive lung squamous cell carcinoma (LUSC) with severe hyperamylasemia. To our knowledge, no previous cases of LUSC have been reported with both histological evidence of amylase production and hyperamylasemia. This case provides new evidence that LUSC can produce amylase and cause hyperamylasemia. ABSTRACT A 74‐year‐old
Yusuke Nakamura, Shohei Hara, Noriaki Nishimura, Yuto Goto, Nobuhiko Tsukada, Nana Yazawa, Yoshimasa Nakazato, Yokose Tomoyuki, Kazuyuki Ishida, Yasuo Shimizu, Seiji Niho   +10 more
wiley   +1 more source

Sialyl-Tn Polysaccharide A1 as an Entirely Carbohydrate Immunogen: Synthesis and Immunological Evaluation

, 2016
Sialyl Thomsen-nouveau (STn) is a tumor-associated carbohydrate antigen (TACA) that is overexpressed in a variety of carcinomas such as breast, ovarian, and colon cancer.
Mengchao Shi (3232308), Kristopher A. Kleski (3232305), Kevin R. Trabbic (3232302), Jean-Paul Bourgault (3232311), Peter R. Andreana (1590037)   +4 more
core   +1 more source

GlycoChat Uncovers Glycan–Lectin Circuits in the Tumor Microenvironment of Pancreatic Cancer

Advanced Science, Volume 13, Issue 14, 9 March 2026.
Aberrant glycosylation drives cancer progression, yet its role in the tumor microenvironment remains unclear. We developed GlycoChat to map glycan–lectin circuits at single‐cell resolution. We discovered that cancer cells induce immunosuppressive macrophage differentiation and impair phagocytosis through interactions with CLEC10A and SIGLEC3 ...
Dinh Xuan Tuan Anh, Sunanda Keisham, Arun Burramsetty, Lalhaba Oinam, Koichiro Kumano, Akihiro Kuno, Osamu Shimomura, Tatsuya Oda, Hiroaki Tateno   +8 more
wiley   +1 more source

Fraction A of armadillo submandibular glycoprotein and its desialylated product as sialyl-Tn and Tn receptors for lectins [PDF]

, 1995
Fraction A of the armadillo submandibular glycoprotein (ASG-A) is one of the simplest glycoproteins among mammalian salivary mucins. The carbohydrate side chains of this mucous glycoprotein have one-third of the NeuAcα2→6GalNAc (sialyl-Tn) sequence and ...
Wu, Albert M, Anthony Herp, Albert M Wu, Herp, Anthony, June H Wu, Song, Shuh-Chyung, Shuh-Chyung Song, F-shiun Shen, Wu, June H, Shen, F-shiun   +9 more
core   +1 more source

Separation Methods Affect Glycan Patterns in Extracellular Vesicle Preparations From Canine Osteoblasts and Osteosarcoma Cells

Journal of Extracellular Biology, Volume 5, Issue 2, February 2026.
ABSTRACT Extracellular vesicles (EVs) are nanosized, membrane‐enclosed particles released by cells, facilitating intercellular communication via the transfer of bioactive molecules from producing to recipient cells. EVs are involved in several physiological and pathological processes, including cancer progression.
Daniela Cortes Galvez, Silvio Kau‐Strebinger, Simone Gabner, Ingrid Walter   +3 more
wiley   +1 more source

A combined computational-experimental approach to define the structural origin of antibody recognition of sialyl-Tn, a tumor-associated carbohydrate antigen. [PDF]

, 2018
Anti-carbohydrate monoclonal antibodies (mAbs) hold great promise as cancer therapeutics and diagnostics. However, their specificity can be mixed, and detailed characterization is problematic, because antibody-glycan complexes are challenging to ...
Chen, Xi, Nivedha, Anita K, Norn, Christoffer, Marshanski, Tal, Grant, Oliver C, Woods, Robert J, Leviatan Ben-Arye, Shani, Yu, Hai, Amon, Ron, Glushka, John N, Makeneni, Spandana, Fleishman, Sarel J, Padler-Karavani, Vered   +12 more
core   +1 more source

Native Tn only becomes an antigen when its protein no longer matches the protein of natural innate anti-Tn-reactive IgM

, 2023
   In view of the simultaneous formation of Helix pomatia-specific, Tn/serologically A-like glycolipids with germline-encoded anti-Helix pomatia-, Tn/A cross- reactive  IgM in the ovary of a healthy and fertile mouse, it is suggested that the mammalian ...
Peter Arend (560469)
core   +1 more source