Results 41 to 50 of about 542,634 (177)

Single‐Cell Glycomics of the Pancreatic Tumor Microenvironment: Technologies, Glyco‐Immune Checkpoints, and Tumor–Immune Communication

Advanced Biology, Volume 10, Issue 8, August 2026.
Single‐cell glycomics reveals how epithelial–mesenchymal transition (EMT) remodels the cancer cell glycome and reshapes communication with immune cells. Emerging technologies, including scGR‐seq and GlycoChat, uncover glyco‐immune checkpoints in pancreatic cancer, highlighting glycans as active regulators of tumor–immune interactions and providing a ...
Dinh Xuan Tuan Anh, Hiroaki Tateno
wiley   +1 more source

Beyond Sequence: Posttranslational Remodeling of Antigens in Autoimmunity

Immunological Reviews, Volume 341, Issue 1, August 2026.
ABSTRACT Autoimmune responses are often attributed to failed tolerance to self‐proteins, yet protein expression alone cannot explain why certain antigens dominate disease, why autoreactivity emerges under stress, or why specific HLA alleles shape risk.
Cynthiya Shrestha, Holly M. Weisfelder, Thanh D. Do   +2 more
wiley   +1 more source

Alcohol‐induced altered glycans in human tracheal epithelial cells promote bacterial adhesion

FEBS Open Bio, Volume 16, Issue 6, Page 1142-1149, June 2026.
Alcohol induces altered glycans to promote bacteria adhesion. Heavy alcohol drinking is known to increase the risk of bacterial pneumonia. However, the link between alcohol levels and risk of infection remains underexplored. Recently, we found that alcohol induced α2‐6sialo mucin O‐glycans in human tracheobronchial epithelial cells, which mediated the ...
Pi‐Wan Cheng, Souvik Datta, Derrick R. Samuelson   +2 more
wiley   +1 more source

Circulating Sialyl Lewisa, Sialyl LewisX, and Sialyl Tn Antigens in Patients with Diffuse Type of Gastric Cancer [PDF]

, 2003
The aim of this study was to clarify whether or not preoperative serum levels of sialyl Lewisa (CA19-9), sialyl LewisX (SLX), and sialyl Tn (STN) antigens are predictors for diffuse type gastric cancer.
Nanashima, Atsushi, Tsuji, Takashi, Akiyama, Shinji, Kamihira, Shimeru, Ishikawa, Hiroshi, Sawai, Terumitsu, Takeshita, Hiroaki, Nagayasu, Takeshi, Yamaguchi, Hiroyuki, Nakagoe, Tohru, Tanaka, Kenji, Hidaka, Shigekazu, Ohbatake, Masayuki, Yasutake, Toru   +13 more
core   +2 more sources

A Rational Optimization Approach for the Development of a Multiplexed Lateral Flow Immunoassay: Detection of Nonepithelial Ovarian Cancer Markers in Human Serum

Advanced Science, Volume 13, Issue 31, 4 June 2026.
This study outlines the developmental pipeline of a multiplexed nanozyme‐based lateral flow immunoassay for the purpose of ovarian germ cell tumor detection. It demonstrates the application of a design of experiments optimization approach for nanozyme probe conjugate development.
Aida Abdelwahed, Carl E. Eskildsen, Luca Panariello, André Shamsabadi, Christy J. Sadler, Edmund H. Wilkes, Federico Galvanin, Yuxi Cheng, Sara Carvalho, Srdjan Saso, Molly M. Stevens   +10 more
wiley   +1 more source

Abnormal Protein Glycosylation and Activated PI3K/Akt/mTOR Pathway: Role in Bladder Cancer Prognosis and Targeted Therapeutics.

PLoS ONE, 2015
Muscle invasive bladder cancer (MIBC, stage ≥T2) is generally associated with poor prognosis, constituting the second most common cause of death among genitourinary tumours.
Céu Costa, Sofia Pereira, Luís Lima, Luís Lima, Andreia Peixoto, Elisabete Fernandes, Diogo Neves, Manuel Neves, Cristiana Gaiteiro, Ana Tavares, Rui M Gil da Costa, Ricardo Cruz, Teresina Amaro, Paula A Oliveira, José Alexandre Ferreira, Lúcio L Santos   +15 more
doaj   +1 more source

Reprogramming the Immune Landscape of Inflammatory Breast Cancer

Advanced Science, Volume 13, Issue 36, 29 June 2026.
Inflammatory breast cancer is the most lethal subtype of breast cancer and is characterized by an immunosuppressive tumor microenvironment (TME) driven by a complex network of immune cells and inflammatory cytokines, contributing to its aggressiveness and treatment challenges. Immune checkpoint inhibitors, either alone or in combination, show potential
Verena Martinez‐Rodriguez, Suguru Ogata, Xiaoping Wang, Naoto T. Ueno   +3 more
wiley   +1 more source

Response of high-risk of recurrence/progression bladder tumours expressing sialyl-Tn and sialyl-6-T to BCG immunotherapy. [PDF]

, 2013
Background: High risk of recurrence/progression bladder tumours is treated with Bacillus Calmette-Gue ́ rin (BCG) immunotherapy after complete resection of the tumour.
Videira PA, DALL'OLIO, FABIO, Amaro T, Severino PF, Tavares A, Santos L, Fernandes E, Ferreira JA, Cruz R, Silva M, Pereira S, Reis CA, Lima L, Miranda A, Amado F   +14 more
core   +3 more sources

Sialyl-Tn Antigen-Imprinted Dual Fluorescent Core–Shell Nanoparticles for Ratiometric Sialyl-Tn Antigen Detection and Dual-Color Labeling of Cancer Cells

Sialyl-Tn (STn or sialyl-Thomsen-nouveau) is a carbohydrate antigen expressed by more than 80% of human carcinomas. We here report a strategy for ratiometric STn detection and dual-color cancer cell labeling, particularly, by molecularly imprinted ...
Sandra Behren (2873045), Ulrika Westerlind (1710604), Shan Jiang (121292), Kornelia Gawlitza (1421098), Jenny L. Persson (5175584), Tianyan Wang (14129038), Knut Rurack (1416820)   +6 more
core   +1 more source

MGL‐Based Drug Conjugate: A Novel Glycan‐Targeting Strategy for Potential Precision Cancer Therapy

ChemistryEurope, Volume 4, Issue 5, May 2026.
An engineered macrophage galactose‐type lectin (MGL)‐based conjugate (mMGL‐vcMMAE), incorporating an exposed cysteine for site‐specific drug linkage, preserves stability, binding profile, and affinity of the native MGL carbohydrate recognition domain. It also selectively targets Tn/STn‐expressing cancer cells and shows recognition of colorectal cancer ...
Carlos D. L. Lima, Rafaela Abrantes, Victor Lorrain, Joana Gomes, Reyes Núñez‐Franco, João P. M. António, Catarina Gomes, Ana Gimeno, Benedita A. Pinheiro, Angelina S. Palma, Jesús Jiménez‐Barbero, Pedro M. P. Gois, Gonzalo Jiménez‐Osés, Sandra J. van Vliet, Celso A. Reis, Filipa Marcelo   +15 more
wiley   +1 more source