Results 61 to 70 of about 542,634 (177)

Effect of C1GalT siRNA on cellular TF, Tn, sialyl-Tn and Core 3 glycan expressions in SW620 cells.

, 2013
Sub-confluent SW620 cells cultured in 8-well glass chamber slides were treated without or with C1GalT siRNA or control non-targeting siRNA for 48 hr before the expressions of cell TF, Tn, sialyl-Tn and GSL-II binding (Core 3-associated) glycans were ...
Lu-Gang Yu (394218), Hannah Barrow (394214), Carrie A. Duckworth (394216), Jonathan M. Rhodes (394217), Benjamin Tam (394215)   +4 more
core   +1 more source

Glycopattern comparison of sperm and exosomes from conventional in vitro fertilization and rescue intracytoplasmic sperm injection: Enhancing sperm motility through exosome‐mediated glycan modulation

View
Infertility is a global issue, with male factors contributing to approximately 50% of cases. While assisted reproductive technologies (ART) resolve 30%–50% of cases, 2%–5% of IVF failures require rescue intracytoplasmic sperm injection (RICSI).
Muhammad Anas Ramzan, Zhedong Yang, Li Cao, Jinyuan Zhang, Fei Wu, Miaomiao Xin, Bo Guo, Lumin Wang, Lingyu Zhao, Yannan Qin, Chengcheng Liu   +10 more
doaj   +1 more source

Sialyl-Tn glycan epitope as a target for pancreatic cancer therapies

Frontiers in Oncology
Pancreatic cancer (PC) is the sixth leading cause of cancer-related deaths worldwide, primarily due to late-stage diagnosis and limited treatment options.
Rafaela Abrantes, Rafaela Abrantes, Rafaela Abrantes, Joanne Lopes, Daniel Lopes, Joana Gomes, Joana Gomes, Sónia A. Melo, Sónia A. Melo, Sónia A. Melo, Celso A. Reis, Celso A. Reis, Celso A. Reis, Celso A. Reis, Celso A. Reis   +14 more
doaj   +1 more source

The Role of Sialyl-Tn in Cancer

, 2016
Activation of an aberrant glycosylation pathway in cancer cells can lead to expression of the onco-foetal sialyl-Tn (sTn) antigen. STn is a truncated O-glycan containing a sialic acid α-2,6 linked to GalNAc α-O-Ser/Thr and is associated with an adverse ...
Jennifer Munkley
core   +1 more source

MCT1 lactate transporter blockade re-invigorates anti-tumor immunity through metabolic rewiring of dendritic cells in melanoma

Nature Communications
Dendritic cells (DC) are key players in antitumor immune responses. Tumors exploit their plasticity to escape immune control; their aberrant surface carbohydrate patterns (e.g., glycans) shape immune responses through lectin binding, and manipulate the ...
Camille Niveau, Mélanie Cettour-Cave, Stéphane Mouret, Eleonora Sosa Cuevas, Mylene Pezet, Benoît Roubinet, Hugo Gil, Florence De Fraipont, Ludovic Landemarre, Julie Charles, Philippe Saas, Caroline Aspord   +11 more
doaj   +1 more source

Abstracts

Molecular Oncology, Volume 20, Issue S1, Page 1-692, August 2026.
Abstracts submitted to the ‘EACR 2026 Congress: Innovative Cancer Science’, from 08–11 June 2026 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley   +1 more source

Clinical evaluation of circulating serum sialyl Tn antigen levels in patients with epithelial ovarian cancer.

, 1991
Sialyl Tn antigen (NeuAc alpha 2----6GalNac alpha 1----0-Ser/Thr [STN]) with antigenic specificity in the core structure of mucin-type carbohydrate chains has been determined.
T Terao, H Kobayashi, Y Kawashima
core   +1 more source

L'antigène sialyl-Tn dans le cancer du sein (étude de la O-glycosylation et de son influence sur la croissance de lignées cellulaires sialyl-Tn positives) [PDF]

, 2004
Le cancer du sein est le premier cancer féminin en France, en termes de fréquence et de mortalité. L'antigène sialyl-Tn, une structure O-glycannique détectée chez 40% des patientes, est associé à une diminution du taux de survie.
JULIEN, Sylvain, DELANNOY, Philippe, LE BOURHIS, Xuefen   +2 more
core  

Mucoepidermoid carcinoma-associated expression of MUC5AC, MUC5B and mucin-type carbohydrate antigen sialyl-Tn in the parotid gland

, 2017
Objectives The aberrant expression of mucins and mucin-type carbohydrates has been described in many types of cancer, including mucoepidermoid carcinoma (MEC), a malignant salivary gland tumor.
Bolscher, J.G.M., Matse, J.H., Wiresh K. Bharos, Jan G.M. Bolscher, Veerman, E.C.I., Johannes H. Matse, Elisabeth Bloemena, Bolscher, Jan G.M., Matse, Johannes H., Veerman, Enno C.I., Bharos, Wiresh K., Bloemena, Elisabeth, Bharos, W.K., Enno C.I. Veerman, Bloemena, E.   +14 more
core   +1 more source

Oxygen by Carbon Replacement at the Glycosidic Linkage Modulates the Sugar Conformation in Tn Antigen Mimics [PDF]

, 2018
N-Acetylgalactosamine (GalNAc) α-O-linked to l-threonine (Thr) (Tn antigen) and several mimics of this Tn antigen have been synthesized to explore the impact of the underlying amino acid in the presentation mode of the carbohydrate moiety. The structural
Alberto Avenoza (1470724), Corzana, Francisco [0000-0001-5597-8127], Matías, Cristina, Iris A. Bermejo (4677730), Gonzalo Jiménez-Osés, Jesús M. Peregrina, Jesús H. Busto (1470733), Bermejo, Iris A. [0000-0001-8864-4852], Claudio D. Navo (1470727), Pablo Tovillas, Cristina Matías (6116069), Busto, Jesús H. [0000-0003-4403-4790], Francisco Corzana (1470730), Alberto Avenoza, Francisco Corzana, Pablo Tovillas (5099498), Navo, Claudio D. [0000-0003-0161-412X], Peregrina, Jesús M. [0000-0003-3778-7065], Cristina Matías, Claudio D. Navo, Companón, Ismael, Paula Oroz (5099504), Ismael Compañón, Gonzalo Jiménez-Osés (1340502), Avenoza, Alberto [0000-0002-5465-3555], Ismael Compañón (1858135), Paula Oroz, María M. Zurbano, Jiménez-Osés, Gonzalo [0000-0003-0105-4337], Oroz, Paula [0000-0003-0854-5059], Tovillas, Pablo, Zurbano, María M. [0000-0001-6370-3537], Jesús M. Peregrina (1470736), Jesús H. Busto, María M. Zurbano (1830772), Iris A. Bermejo   +35 more
core   +1 more source