Results 31 to 40 of about 542,634 (177)
PLoS ONE, 2020 Mucin-type O-glycans are involved in cancer initiation and progression, although details of their biological and clinicopathological roles remain unclear.
Noriteru Doi +5 more
doaj +1 more source
Expression of ST6GalNAc1 and sialyl-Tn antigen enhances endometrial receptivity [PDF]
, 2020 Abstract BackgroundTo characterize molecular mechanism underlying the regulation of sialylated glycan expression and its roles for endometrial receptivity and embryo implantation. Here, we characterized the role of a truncated form of sialylated O-glycan, sialyl-Tn, for endometrial receptivity.MethodsThe transcriptomes of human endometrium at ...
Hee-Jung Choi +10 more
openaire +1 more source
Monoclonal Antibodies Recognising Sialyl-Tn: Production and Application to Immunochemistry [PDF]
, 1994 In order to develop reagents that can detect the exposed sialyl-Tn antigen (NeuAcα2,6GalNAcαl-O-Ser/Thr) on tumour-associated mucins, we have prepared monoclonal antibodies (mabs 3C2 and 3D1, both IgM) against ovine submaxillary mucin (OSM; >98% of ...
Shield, Paul W. +3 more
core +1 more source
Cancer Management and Research, 2020 Feng Xu,1,* Dong Wang,2,* JianXiu Cui,1 Jie Li,1 Hongchuan Jiang1 1Department of Breast Surgery, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, People’s Republic of China; 2Department of Oncology, Affiliated Hospital of ...
Xu F, Wang D, Cui J, Li J, Jiang H
doaj
Frontiers in Immunology, 2018 Impressive clinical efficacy of chimeric antigen receptor (CAR)-engineered T cell therapy for hematological malignancies have prompted significant efforts in achieving similar responses in solid tumors. The lack of truly restricted and uniform expression
John P. Murad +14 more
doaj +1 more source
Extended half-life target module for sustainable UniCAR T-cell treatment of STn-expressing cancers
Journal of Experimental & Clinical Cancer Research, 2020 Background Adapter chimeric antigen receptor (CAR) approaches have emerged has promising strategies to increase clinical safety of CAR T-cell therapy. In the UniCAR system, the safety switch is controlled via a target module (TM) which is characterized ...
Liliana R. Loureiro +10 more
doaj +1 more source
Carbohydrate receptor-mediated gene transfer to human T leukaemic cells [PDF]
, 1994 The mucin-type carbohydrate Tn cryptantigen (GalNAcα1-O-Ser/Thr, where GalNAc is N-acetyl-D-galactosamine) is expressed in many carcinomas, in haemopoietic disorders including the Tn syndrome, and on human immunodeficiency virus (HIV) coat glycoproteins,
Berger, Eric G. +12 more
core +1 more source
Mass Spectrometry Reviews, EarlyView.ABSTRACT The use of MALDI mass spectrometry for the analysis of carbohydrates and glycoconjugates is a well‐established technique and this comprehensive review is the twelfth update of the original article published in 1999 and brings coverage of the literature to the end of 2024.
David J. Harvey
wiley +1 more source
Angewandte Chemie, Volume 138, Issue 39, 21 September 2026.Anti‐Glykan‐Antikörper spielen sowohl bei Gesundheit als auch bei Krankheit eine wesentliche Rolle. Der Zugang zu neuartigen Glykanstrukturen ermöglicht Fortschritte bei der Antikörpercharakterisierung für die Entdeckung von Biomarkern, die Antikörperentwicklung und das Impfstoffdesign.
Fabienne Weber +4 more
wiley +1 more source
Journal of Biomedical Materials Research Part A, Volume 114, Issue 9, September 2026.ABSTRACT Type I collagen (Col‐I) is widely used in biomaterials and cell biology, yet the glycosignature of commercial Col‐I preparations remains poorly characterized. Here, we established an integrated lectin‐based workflow to profile the glycan landscape of commercially sourced bovine pepsin‐soluble Col‐I as supplied for biomaterial use.
Mohamed EL‐Melegy +2 more
wiley +1 more source