Results 11 to 20 of about 542,634 (177)

ST6GalNAc-I controls expression of sialyl-Tn antigen in gastrointestinal tissues

Frontiers in Bioscience, 2011
Sialyl-Tn is a simple mucin-type carbohydrate antigen aberrantly expressed in gastrointestinal adenocarcinomas and in the precursor lesion intestinal metaplasia. Sialyl-Tn tumour expression is an independent indicator of poor prognosis. We have previously shown in vitro that ST6GalNAc-I and ST6GalNAc-II sialyltransferases can synthesize sialyl-Tn.
Marcos, Nuno, Bennett, Eric, Gomes, Joana, Magalhaes, Ana, Gomes, Catarina, David, Leonor, Dar, Imran, Jeanneau, Charlotte, DeFrees, Shawn, Krustrup, Dorrit, Vogel, Lotte, Kure, Elin, Burchell, Joy, Taylor-Papadimitriou, Joyce, Clausen, Henrik, Mandel, Ulla, Reis, Celso   +16 more
core   +9 more sources

Overexpression of tumour‐ssociated carbohydrate antigen sialyl‐Tn in advanced bladder tumours [PDF]

Molecular Oncology, 2013
Little is known on the expression of the tumour‐associated carbohydrate antigen sialyl‐Tn (STn), in bladder cancer. We report here that 75% of the high‐grade bladder tumours, presenting elevated proliferation rates and high risk of recurrence/progression expressed STn.
Ferreira J. A., Videira P. A., Lima L., Pereira S., Silva M., Carrascal M., SEVERINO, PAULO, Fernandes E., Almeida A., Costa C., Vitorino R., Amaro T., Oliveira M. J., Reis C. A., DALL'OLIO, FABIO, Amado F., Santos L. L.   +16 more
core   +7 more sources

The Critical Role of GALNTs-Regulated O-GalNAc Glycosylation in Cancer Malignancy. [PDF]

FASEB J
The GALNT family initiates mucin‐type O‐GalNAc glycosylation in the Golgi apparatus and how regulatory mechanisms, including GALNT relocalization and microRNA control, modulate this process. Dysregulated O‐GalNAc glycosylation alters key cellular behaviors and promotes cancer malignancy, highlighting its relevance to tumor progression as well as its ...
Liu J, Wu S, Zhang G, Li J, Yin Y, Uiiah A, Peng S, Fu Y.   +7 more
europepmc   +2 more sources

Therapeutic targeting of cancer stem cell-specific surface glycans and glycoproteins [PDF]

Discover Oncology
Cancer stem cells (CSCs) represent a critical subpopulation within tumors, driving malignancy, metastasis, and therapeutic resistance. Their unique biological attributes, particularly the distinctive landscape of surface glycans and glycoproteins, offer ...
Mutaz Jamal Al-khreisat, Waleed K. Abdulsahib, Ihsan Khudhair Jasim, H. Malathi, Priya Priyadarshini Nayak, D. Alex Anand, Gunjan Mukherjee, Aashna Sinha, Gulsara Ruziyeva   +8 more
doaj   +2 more sources

Pan-carcinoma sialyl-Tn-targeting expands CAR therapy to solid tumors [PDF]

Cell Reports Medicine
Summary: Accurate identification of tumor-specific markers is vital for developing chimeric antigen receptor (CAR)-based therapies. While cell surface antigens are seldom cancer-restricted, their post-translational modifications (PTMs), particularly ...
Rafaela Abrantes, Christopher Forcados, David J. Warren, Liliana Santos-Ferreira, Karianne Giller Fleten, Emanuel Senra, Ana Filipa Costa, Klara Krpina, Rui Henrique, Ann Magritt Liberg, Puneet Rawat, Pascal Gelebart, Emmet McCormack, Line Bjørge, Ben Davidson, Victor Greiff, Daniela Elena Costea, Filipe Pinto, Kjersti Flatmark, Catarina Gomes, Else Marit Inderberg, Celso A. Reis, Sébastien Wälchli   +22 more
doaj   +2 more sources

From Lock-and-Key to Velcro: Glycan-Dependent T Cell Recruiter Redefines Cancer Cell Targeting With Density-Dependent Recognition. [PDF]

MedComm (2020)
MedComm, Volume 7, Issue 2, February 2026.
Wei P, Tong A, Zhao L.
europepmc   +2 more sources

Sialyl-Tn expression correlates with reduced c-Myc and immune modulation in triple negative breast cancer [PDF]

Scientific Reports
Triple negative breast cancer (TNBC) is an aggressive, heterogeneous cancer with lack of targeted therapies. The cancer-associated sialyl-Tn (STn) antigen has a significant role in cancer, yet its involvement in TNBC remains unexplored.
Rita Adubeiro Lourenço, Daniela Ferreira Barreira, Carla Lopes, Pedro Granjo, Ana Sofia Rodrigues, Zélia Silva, Manuela Martins, Ana Rita Grosso, Paula A. Videira   +8 more
doaj   +2 more sources

Targeted O-glycoproteomics for the development of diagnostic markers for advanced colorectal cancer

Frontiers in Oncology, 2023
Aberrant glycosylation is a prominent feature of cancer, that can be used as targets to improve the existing cancer biomarkers, and help to assess metastasis risks, and therapeutic effects.
Daisuke Takakura, Shoko Ohashi, Noritoshi Kobayashi, Motohiko Tokuhisa, Yasushi Ichikawa, Nana Kawasaki   +5 more
doaj   +1 more source

Combined Action of Anti-MUC1 Monoclonal Antibody and Pyrazole-Platinum(II) Complexes Reveals Higher Effectiveness towards Apoptotic Response in Comparison with Monotherapy in AGS Gastric Cancer Cells

Pharmaceutics, 2021
MUC1 mucin is a transmembrane glycoprotein aberrantly overexpressed and underglycosylated in most epithelium origin cancers. Combining chemotherapeutics with monoclonal antibodies toward cancer-related antigens is one of the new strategies in cancer ...
Katarzyna Supruniuk, Robert Czarnomysy, Anna Muszyńska, Iwona Radziejewska   +3 more
doaj   +1 more source

Sialyl-tn antigen expression in Crohn's colitis [PDF]

Inflammatory Bowel Diseases, 1997
: Expression of the mucin-associated sialyl-Tn (STn) antigen is correlated with malignant progression in the colon. In patients with longstanding ulcerative colitis (UC) who never exhibited colonic dysplasia, STn was expressed in fewer than 15% of nondysplastic surveillance colonoscopic biopsies, whereas matched patients who developed colon cancer ...
A, Ta, N, Harpaz, C, Bodian, A, Roston, L, Oberman, A, Chen, S, Itzkowitz   +6 more
openaire   +2 more sources