Results 21 to 30 of about 542,634 (177)

Polymeric nanoparticles targeting Sialyl-Tn in gastric cancer: A live tracking under flow conditions

Materials Today Bio, 2022
Drug delivery using nanoparticles (NPs) represents a potential approach for therapy in cancer, such gastric cancer (GC) due to their targeting ability and controlled release properties.
Francisca Diniz, Maria Azevedo, Flávia Sousa, Hugo Osório, Diana Campos, Paula Sampaio, Joana Gomes, Bruno Sarmento, Celso A. Reis   +8 more
doaj   +1 more source

Development of an automated chemiluminescent immunoassay for cancer antigen 72–4 and the evaluation of its analytical performance

Practical Laboratory Medicine, 2023
Objectives: Cancer antigen (CA) 72–4 assay is widely used for monitoring gastric and ovarian cancers. The antigen is a mucin-like, tumor-associated glycoprotein known as TAG-72.
Fusamitsu Yanagihara, Hideaki Okura, Hisashi Ichikawa, Takuma Shirakawa, You Pan, Bailin Tu, Zhihong Lin, Ryan Bonn, Sridevi Kurella, Beth Schodin, Toru Yoshimura   +10 more
doaj   +1 more source

Diagnostic value of tumor markers in identifying favorable or unfavorable subsets in patients with cancer of unknown primary: a retrospective study

BMC Cancer, 2022
Background Routine measurement of tumor markers is not recommended in daily clinical practice for patients with cancer of unknown primary (CUP). We evaluated the diagnostic value of tumor markers in identifying favorable or unfavorable subsets in ...
Shigemasa Takamizawa, Tatsunori Shimoi, Masayuki Yoshida, Momoko Tokura, Shu Yazaki, Chiharu Mizoguchi, Ayumi Saito, Shosuke Kita, Kasumi Yamamoto, Yuki Kojima, Hitomi Sumiyoshi-Okuma, Tadaaki Nishikawa, Emi Noguchi, Kazuki Sudo, Kan Yonemori   +14 more
doaj   +1 more source

Different expression of Tn and sialyl-Tn antigens between normal and diseased human gastric epithelial cells. [PDF]

, 1998
Thomsen-Friedenreich antigen (T antigen) has been supposed to be a cancer-specific carbohydrate antigen. We have previously shown that one third of the Japanese population normally expressed T antigen in gastric surface epithelia and the other two thirds
Tsuji, Takao, Nakatou, Tatsuaki, Sotozono, Masaaki, Yoshida, Atushi, Okada, Yoshio   +4 more
core   +1 more source

Shigella flexneri targets human colonic goblet cells by O antigen binding to Sialyl-Tn and Tn antigens via glycan-glycan interactions

, 2020
Shigella flexneri targets colonic cells in humans to initiate invasive infection processes that lead to dysentery, and direct interactions between their lipopolysaccharide O antigens and blood group A related glycans are involved in the cell adherence ...
Tran, ENH, Poole, J., Tran, E.N.H., Tse, E., Jennings, M.P., Morona, R, Poole, J, Tse, E, Day, C.J., McCartney, E., Day, CJ, Jennings, MP, McCartney, E, Morona, R.   +13 more
core   +1 more source

Humanized anti-Sialyl-Tn antibodies for the treatment of ovarian carcinoma. [PDF]

PLoS ONE, 2018
The expression of Sialyl-Tn (STn) in tumors is associated with metastatic disease, poor prognosis, and reduced overall survival. STn is expressed on ovarian cancer biomarkers including CA-125 (MUC16) and MUC1, and elevated serum levels of STn in ovarian ...
David A Eavarone, Linah Al-Alem, Alexey Lugovskoy, Jillian M Prendergast, Rawan I Nazer, Jenna N Stein, Daniel T Dransfield, Jeff Behrens, Bo R Rueda   +8 more
doaj   +1 more source

Demethylation of the Cosmc Promoter Alleviates the Progression of Breast Cancer Through Downregulation of the Tn and Sialyl-Tn Antigens [Retraction]

Cancer Management and Research, 2022
Xu F, Wang D, Cui J, Li J, Jiang H. Cancer Manag Res. 2020;12:1017–1027. At the authors request, the Editor and Publisher of Cancer Management and Research wish to retract the published article.
Xu F, Wang D, Cui J, Li J, Jiang H
doaj  

Diagnostic value of sialyl‐Tn immunocytochemistry in breast cancer presenting with pathological nipple discharge

Cancer Medicine, 2021
Background Mucin‐associated sialyl‐Tn (sTn) antigen is overexpressed and related with adverse outcome in breast cancer (BC). The role of sTn in BC has not been well defined in pathological nipple discharge (PND) cytology.
Feng Xu, Yue Gao, Xiaoli Diao, Jie Li, Hongchuan Jiang, Hongying Zhao   +5 more
doaj   +1 more source

O-glycans truncation modulates gastric cancer cell signaling and transcription leading to a more aggressive phenotypeResearch in context

EBioMedicine, 2019
Background: Changes in glycosylation are known to play critical roles during gastric carcinogenesis. Expression of truncated O-glycans, such as the Sialyl-Tn (STn) antigen, is a common feature shared by many cancers and is associated with cancer ...
Daniela Freitas, Diana Campos, Joana Gomes, Filipe Pinto, Joana A. Macedo, Rita Matos, Stefan Mereiter, Marta T. Pinto, António Polónia, Fátima Gartner, Ana Magalhães, Celso A. Reis   +11 more
doaj   +1 more source

Sialyl-Tn in Cancer: (How) Did We Miss the Target?

Biomolecules, 2012
Sialyl-Tn antigen (STn) is a short O-glycan containing a sialic acid residue a2,6-linked to GalNAca-O-Ser/Thr. The biosynthesis of STn is mediated by a specific sialyltransferase termed ST6GalNAc I, which competes with O-glycans elongating ...
Philippe Delannoy, Paula A. Videira, Sylvain Julien   +2 more
doaj   +1 more source