Results 121 to 130 of about 7,429 (165)

Expression of Sialyl Lewisx Antigen on Human T Cells

Cellular Immunology, 1993
Sialyl Lewis(x) (sLe(x)) antigen, which has been introduced as tumor-associated cell surface carbohydrates, was demonstrated to be expressed on a subpopulation of human CD4+ and CD8+ T cells. It was also demonstrated that the majority of gamma delta T cells as well as natural killer cells expressed a high level of sLe(x) antigen.
S, Ohta, N, Hanai, S, Habu, T, Nishimura
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[Clinical value of carbohydrate antigens, sialyl Lewis-x and sialyl Lewis-a in gastrointestinal cancer].

Nihon Geka Gakkai zasshi, 1996
To evaluate clinical importance of the expression of sialyl Lewis-X (sLe(x)) and sialyl Lewis-a antigen (sLe(a)) in gastrointestinal cancers, we examined immunohistochemically expression of the two antigens in esophageal, gastric, colorectal, and pancreatic cancer.
S, Nakamori, I, Arai, S, Okamura, S, Imaoka, H, Furukawa, T, Kabuto, O, Ishikawa, Y, Sasaki, M, Kameyama, T, Iwanaga   +9 more
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Endothelial-selectin ligands sialyl Lewisx and sialyl Lewisa are differentiation antigens immunogenic in human melanoma

Cancer, 1997
Sialyl Lewis(x) (sLe(x)) and sialyl Lewis(a) (sLe(a)), the endothelial-selectin ligands involved in extravasation of neutrophils and carcinomas, have been identified in human melanoma. This study explored the following issue: If these ligands are immunogenic tumor-differentiation antigens, they would be potential targets for immunotherapy because of ...
M H, Ravindranath, A A, Amiri, P M, Bauer, M C, Kelley, R, Essner, D L, Morton   +5 more
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Expression of the blood-group-related antigens Sialyl Lewis a, Sialyl Lewis x and Lewis y in term placentas of normal, preeclampsia, IUGR- and HELLP-complicated pregnancies

Histochemistry and Cell Biology, 2007
Lewis antigens belong to the blood group of antigens and mediate cellular adhesion through interaction with selectins. Invasive trophoblasts use an array of adhesion molecules to facilitate cell-cell and cell-extracellular matrix interactions. Here, we examined immunohistochemically the expression of Sialyl Lewis a (sLe(a)), Sialyl Lewis x (sLe(x)) and
Vassilis, Minas, Ioannis, Mylonas, Barbara, Schiessl, Doris, Mayr, Sandra, Schulze, Klaus, Friese, Udo, Jeschke, Antonis, Makrigiannakis   +7 more
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Contribution of carbohydrate antigens sialyl Lewis A and sialyl Lewis X to adhesion of human cancer cells to vascular endothelium.

Cancer research, 1993
The carbohydrate antigen, sialyl Lex, is known to be a ligand for the cell adhesion molecule called ELAM-1 (E-selectin, endothelial cell leukocyte adhesion molecule-1), which is present on cytokine-activated human endothelial cells. Recently, we reported that another carbohydrate antigen, sialyl Lea, can also serve as a ligand for ELAM-1 (A. Takada, K.
A, Takada, K, Ohmori, T, Yoneda, K, Tsuyuoka, A, Hasegawa, M, Kiso, R, Kannagi   +6 more
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[Sialylated Lewis x as a tumor-associated antigen in stomach cancer].

Gan no rinsho. Japan journal of cancer clinics, 1987
Sialylated Lewis (S-Lex) has been studied histologically and serologically in stomach cancer by the CSLEX1 monoclonal antibody. S-Lex was expressed in 73.9% of 46 stomach cancer tissues, 29.4% of metaplastic parts adjacent to cancer, and none of six gastric ulcer tissues including metaplasia. Serologically positive percentages were as follows: 26.0% of
M, Hirota, K, Fukushima, K, Hiratani, S, Funatsu, N, Suyama, A, Yokoyama, M, Hayashida, A, Tomonaga, N, Nakamura, K, Makiyama   +9 more
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Significance of Carbohydrate Antigen Sialyl-Lewis X, Sialyl-Lewis A, and Possible Unknown Ligands to Adhesion of Human Urothelial Cancer Cells to Activated Endothelium

Urologia Internationalis, 2000
<i>Objective:</i> To assess the contribution of the carbohydrate antigens, sialyl-Lewis X (sLe^x) and sialyl-Lewis A (sLe^a), which are known to be ligands for E-selectin, to the adhesion between human urothelial cancer cells and cytokine-activated human endothelial cells.
Y, Fujii, M, Yoshida, L J, Chien, K, Kihara, Y, Kageyama, Y, Yasukochi, H, Oshima   +6 more
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Prevention of experimental autoimmune encephalomyelitis by targeting 6-sulfo sialyl Lewis X glycans involved in lymphocyte homing.

International Immunology
Lymphocyte homing to peripheral lymph nodes (PLN) is critical for immune surveillance. However, autoimmune diseases such as multiple sclerosis (MS) can occur due to excessive immune responses in the PLN.
Qianqian Liu, Wei Xiong, Sachiyo Obara, Hirohito Abo, Hiroko Nakatsukasa, Hiroto Kawashima   +5 more
semanticscholar   +1 more source

A versatile synthesis of the lactoneo-series antigens — synthesis of sialyl dimer Lewis X and of dimer Lewis Y

Tetrahedron Letters, 1997
Abstract Readily available fucosyl α(1–3)azidoglucose disaccharide 6 is transformed with galactosyl donors 7 and 8 into Lewis X trisaccharide building blocks 9 and 12 , respectively, in high yield. Their suitability for the construction of the lactoneo -series glycosphingolipids is demonstrated.
Gerd Hummel, Richard R Schmidt
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Involvement of carbohydrate antigen sialyl Lewisx in colorectal cancer metastasis

Diseases of the Colon & Rectum, 1997
Recognition of metastatic tumor cells with distinct biochemical phenotypes predominant in the primary tumors should be useful not only for establishment of new therapeutic approaches but also for identification of high-risk or low-risk patients for relapse. We examined whether carbohydrate antigens, sialyl Lewis(x) (sLe(x)) and sialyl Lewis(a) (sLe(a))
S, Nakamori, M, Kameyama, S, Imaoka, H, Furukawa, O, Ishikawa, Y, Sasaki, Y, Izumi, T, Irimura   +7 more
openaire   +2 more sources