Results 101 to 110 of about 17,651 (213)

Neisseria gonorrhoeae scavenges host sialic acid for Siglec-mediated, complement-independent suppression of neutrophil activation

mBio
Gonorrhea, caused by the bacterium Neisseria gonorrhoeae (Gc), is characterized by neutrophilic influx to infection sites. Gc has developed mechanisms to resist killing by neutrophils that include modifications to its surface lipooligosaccharide (LOS ...
Amaris J. Cardenas, Keena S. Thomas, Mary W. Broden, Noel J. Ferraro, Marcos M. Pires, Constance M. John, Gary A. Jarvis, Alison K. Criss   +7 more
doaj   +1 more source

Sialylation-associated long non-coding RNA signature predicts the prognosis, tumor microenvironment, and immunotherapy and chemotherapy options in uterine corpus endometrial carcinoma

Cancer Cell International
Background Sialylation in uterine corpus endometrial carcinoma (UCEC) differs significantly from apoptotic and ferroptosis pathways. It plays a crucial role in cancer progression and immune response modulation.
Jun Chen, Tingting Wu, Yongwen Yang
doaj   +1 more source

Supplementing sialic acid analogs overcomes radiotherapy resistance in triple-negative breast cancer by exacerbating ER stress

Redox Biology
Radiotherapy is a cornerstone treatment for triple-negative breast cancer (TNBC), and its incorporation has significantly delayed tumor recurrence.
Muwen Yang, Dongni Shi, Jianbo Lyu, Yibing Pan, Yiyang Lyv, Xiangfu Chen, Ying Ouyang, Yajie Liu, Yue Li, Libing Song   +9 more
doaj   +1 more source

Supplementary Data from Protein Sialylation by Sialyltransferase Involves Radiation Resistance

, 2008
Supplementary Data from Protein Sialylation by Sialyltransferase Involves Radiation ...
Minyoung Lee (484115), Sangwoo Bae (5674433), Hae-June Lee (510693), Yun-Sil Lee (510698)   +3 more
core   +1 more source

Enzymatic basis forn-glycan sialylation

, 2018
Background: Specificity and enzymology of glycan sialylation is poorly understood, despite its importance in biological recognition. Results: ST6GAL1 structure was determined, and substrate binding was modeled to probe active site specificity. Conclusion:
Seetharaman, Jayaraman, Moremen, Kelley W., Moniz, Heather, Kornhaber, Gregory, Tong, Liang, Wells, Lance, Forouhar, Farhad, Meng, Lu, Milaninia, Sahand, Thieker, David, Montelione, Gaetano T., Ramiah, Annapoorani, Woods, Robert J., Veillon, Lucas, Su, Min, Xiang, Yong, Gao, Zhongwei, Bridger, Robert, Azadi, Parastoo   +18 more
core  

Apoptotic signaling by TNFR1 is inhibited by the α2-6 sialylation, but not α2-3 sialylation, of the TNFR1 N-glycans

The TNF-TNFR1 signaling pathway plays a pivotal role in regulating the balance between cell survival and cell death. Upon binding to TNF, plasma membrane-localized TNFR1 initiates survival signaling, whereas TNFR1 internalization promotes caspase ...
Rao, Tejeshwar C., Tao, Jiahui, Sha, Bingdong, Narimatsu, Yoshiki, Clausen, Henrik, Hwang, Jihye, Mattheyses, Alexa L., Bellis, Susan L.   +7 more
core   +1 more source

Dehydrative Sialylation with C2-Hemiketal Sialyl Donors

, 2016
A new method for sialylation involving the dehydrative coupling of sialyl donors with the reagent combination of (p-nitrophenyl)(phenyl) sulfoxide and triflic anhydride is reported.
David Y. Gin (268751), Jannine M. Haberman (3063906)   +1 more
core   +1 more source

Exploring serum N-glycome patterns as candidate non-invasive biomarkers in inguinal hernia

Heliyon
Introduction: Although inguinal hernia (IH) is prevalent in elderly males, research on its specific diagnostic biomarkers is limited. Protein N-glycosylation is one of the most important and ubiquitous post-translational modifications and often results ...
Zhen Cao, Zejian Zhang, Yuanyang Wang, Yilin Zhu, Zepeng Li, Xiaobin Li, Yingmo Shen, Jie Chen, Ziwen Liu   +8 more
doaj   +1 more source

Sialylation-related gene signature predict prognosis and immunotherapy efficacy in low- and high-grade glioma: a PCA-based stratification study

Frontiers in Oncology
BackgroundSialylation is a crucial glycosylation modification of eukaryotic cell surface proteins. Tumor cell growth, immune evasion, and drug resistance are driven by excessive sialylation.
Guidong Zhu, Yan Liu, Rui Liu, Guoqiang Xin, Chengke Zhang, Chengwei Wang   +5 more
doaj   +1 more source

The prognostic value of sialylation-related long non-coding RNAs in lung adenocarcinoma

Scientific Reports
There has been increasing interest in the role of epigenetic modification in cancers recently. Among the various modifications, sialylation has emerged as a dominant subtype implicated in tumor progression, metastasis, immune evasion, and chemoresistance.
Beiru Wang, Chengyu Hou, Xiang Yu, Jiaxin Liu, Jiyong Wang   +4 more
doaj   +1 more source