Results 81 to 90 of about 17,651 (213)

Identification of the Genomic Etiology of Unexplained Congenital Problems in Pediatric Patients: First Reported Case With Coffin–Siris Syndrome and Sialuria From India

Clinical Case Reports, Volume 14, Issue 9, September 2026.
ABSTRACT Coffin–Siris syndrome (CSS) (OMIM:614608) is a rare genetic disorder characterized by global developmental delay (GDD), speech impediment, coarse facial features, and hypoplastic or absent fifth fingernails/toenails. Genetic variants in the SMARCB1 gene are associated with CSS, benign tumors (schwannomas), and rhabdoid tumor predisposition ...
Aparna Bhanushali, Archana Kawalakatt, Smita Kulkarni, Preethi Nair, Ankita Mali, Ashlesha Pradhan, Anirvan Chatterjee   +6 more
wiley   +1 more source

Enzymatic basis forn-glycan sialylation

, 2013
Background: Specificity and enzymology of glycan sialylation is poorly understood, despite its importance in biological recognition. Results: ST6GAL1 structure was determined, and substrate binding was modeled to probe active site specificity. Conclusion:
Seetharaman, Jayaraman, Moremen, Kelley W., Moniz, Heather, Kornhaber, Gregory, Tong, Liang, Wells, Lance, Forouhar, Farhad, Meng, Lu, Milaninia, Sahand, Thieker, David, Montelione, Gaetano T., Ramiah, Annapoorani, Woods, Robert J., Veillon, Lucas, Su, Min, Xiang, Yong, Gao, Zhongwei, Bridger, Robert, Azadi, Parastoo   +18 more
core   +1 more source

Glycoengineering of Chinese Hamster ovary cell for modulating glycoprotein Nlinked sialylation [PDF]

, 2016
Erythropoietin (EPO), a highly glycosylated protein was widely used in anemia of kidney failure. It has been confirmed that enhancing sialic content on EPO can prolong its circulatory half-life, improving EPO therapeutic efficacy.
Chung, Chengyu
core   +1 more source

High-throughput quantification of glycoprotein sialylation [PDF]

, 2011
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemical Engineering, 2011.Cataloged from PDF version of thesis.Includes bibliographical references (p.
Markely, Lam Raga Anggara
core  

Mechanism of action for Troxerutin targeting the sialylation-related gene EGLN3 for the treatment of LUAD

Scientific Reports
Studies have demonstrated that sialylation changes play a vital part in lung adenocarcinoma (LUAD), yet the specific mechanism is uncertain. Hence, in the present research, we screened sialylation-related biomarkers in LUAD using the bioinformatic ...
Yanan Wu, Yanlei Ge, Junqing Gan, Ye Jin, Yishuang Cui, Xuan Zheng, Xuemin Yao, Guogui Sun   +7 more
doaj   +1 more source

Profiling the Glycosignature of Commercial Pepsin‐Soluble Type I Collagen Preparations: A MultiModal Lectin Strategy Reveals Latent Batch Variability

Journal of Biomedical Materials Research Part A, Volume 114, Issue 9, September 2026.
ABSTRACT Type I collagen (Col‐I) is widely used in biomaterials and cell biology, yet the glycosignature of commercial Col‐I preparations remains poorly characterized. Here, we established an integrated lectin‐based workflow to profile the glycan landscape of commercially sourced bovine pepsin‐soluble Col‐I as supplied for biomaterial use.
Mohamed EL‐Melegy, Amir M. Alsharabasy, Abhay Pandit   +2 more
wiley   +1 more source

Identification and experimental validation of a sialylation–related long noncoding RNA signature for prognosis of bladder cancer

BMC Urology
Background The dysregulation of sialylation plays a pivotal role in cancer progression and metastasis, impacting various aspects of tumor behavior. This study aimed to investigate the prognostic significance of long non-coding RNAs (lncRNAs) in relation ...
Yi Qiao, Xintao Tian, Shengxian Li, Haitao Niu   +3 more
doaj   +1 more source

Galectin‐4: A Novel Mediator of Human Intervertebral Disc Degeneration

JOR SPINE, Volume 9, Issue 3, September 2026.
Galectin‐4 correlates with intervertebral disc degeneration, independent of age, sex, or underlying pathology. Functionally, it activates NF‐κB signaling and induces pro‐inflammatory and matrix‐degrading responses, with stronger effects in nucleus pulposus cells, identifying it as a novel molecular player in disc degeneration.
Christine Strauss, Daniel Djojic, Johannes Stadlmann, Josef Georg Grohs, Jürgen Alphonsus, Sebastian Schmidt, Sabine André, Katharina Margareta Pichler, Sara Savic‐Ivanovic, Melanie Cezanne, Mario Rothbauer, Reinhard Windhager, Stefan Toegel   +12 more
wiley   +1 more source

Integrating single-cell sequencing and transcriptome analysis to unravel the mechanistic role of sialylation-related genes in sepsis-induced acute respiratory distress syndrome

Frontiers in Immunology
BackgroundStudies have shown that sialylation of C1 esterase inhibitors is crucial for their interaction with histones, and histone-C1 esterase inhibitor complexes are detected in acute respiratory distress syndrome (ARDS), suggesting a potential role of
Xiaobing Liu, Yake Huang, Hao Zhang, Xia Yang, Quanxing Liu, Jigang Dai   +5 more
doaj   +1 more source

Protein Posttranslational Modifications in Immunity: Molecular Mechanisms and Therapeutic Targets

MedComm, Volume 7, Issue 9, September 2026.
Protein posttranslational modifications, including phosphorylation, ubiquitination, SUMOylation, acetylation, methylation, glycosylation, and other new types, dynamically regulate antigen presentation and recognition, immune signal transduction, antibody production and class switching, immune contraction, immune memory establishment, as well as immune ...
Yuxing Yao, Jinxiu Qian, Qiqiong Liu, Wanting Ye, Ying Xing, Xiuyun Bai, Rongjun Deng, Jue Yang, Cheng Lu, Cheng Xiao, Yuanyan Liu   +10 more
wiley   +1 more source