Results 71 to 80 of about 17,651 (213)

Sialyl Transferase in Human Semen [PDF]

Archives of Andrology, 1988
The activity of the enzyme sialyl transferase, which is responsible for the transfer of sialic acid, has been examined in the following human seminal plasma: (1) originating from semen with sperm counts above 30 X 10(6)/ml and exhibiting normal values of other andrological parameters; (2) from semen with sperm counts below 25 X 10(6)/ml and with other ...
R, Singer, H, Levinsky, M, Sagiv, Z, Zukerman, A, Shoenfeld, D, Allalouf   +5 more
openaire   +2 more sources

The histone deacetylase inhibitor, suberoylanilide hydroxamic acid, restores blood–brain barrier integrity in a human stem cell‐based model of ischaemic stroke

British Journal of Pharmacology, Volume 183, Issue 19, Page 5791-5812, October 2026.
Ischaemic stroke is characterised by acute cerebrovascular occlusion and blood–brain barrier (BBB) breakdown. Our results indicated that the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) ameliorated the loss of BBB integrity, changed the morphology of brain endothelial cells, increased the level of basement membrane and ...
Anikó Szecskó, Koppány Párdi, Zuhao Cui, Gergő Porkoláb, Zsófia Hoyk, Csilla Kovács, Janet F. Adegbite, Virág Fodor, Nárcisz M. Cser, László Dér, Krisztina Nagy, Csilla Sajben, Roland Tengölics, Mária A. Deli, Szilvia Veszelka   +14 more
wiley   +1 more source

Protein O‐Glycosylation Shapes Lymphatic Endothelia and Lymph Node Macrophage Populations

The FASEB Journal, Volume 40, Issue 18, 30 September 2026.
To study the functional roles of O‐glycans on lymphatic endothelia, we deleted Cosmc, the chaperone required for core‐1 O‐glycan synthesis. Loss of core‐1 O‐glycans entailed major changes in glycoprotein composition of lymphatic endothelial cells (LEC), including reduced podoplanin (Pdpn), CD44, and Lyve‐1, and increased ICAM‐1; reduced CD44 was caused
Jasmin Frey, Annkathrin Ratter, Finn Brigger, Louie Cielen, Pascal Kunz, Ea Tulin, Kinga Mikos, Lothar Dieterich, Marco D'Addio, Cornelia Halin, Richard D. Cummings, Vivianne I. Otto   +11 more
wiley   +1 more source

E-cadherin sialylation status.

, 2014
Immunoprecipitation of E-cadherin followed by α2,6- or α2,3-sialylation recognition using Sambucus nigra agglutinin (A) or Maackia amurensis lectin II (MAL-II) (B) lectins, respectively.
Joan Figueras (570237), Sònia Bassagañas (570235), Celso A. Reis (158314), Marta Pérez-Garay (362079), Ana M. Dias (489190), M. Rosa Ortiz (570236), Rosa Peracaula (362084), Salomé S. Pinho (329642), Sandra Carvalho (242319)   +8 more
core   +1 more source

Haemophilus parasuis α-2,3-sialyltransferase-mediated lipooligosaccharide sialylation contributes to bacterial pathogenicity

Virulence, 2018
Bacterial lipooligosaccharide (LOS) is an important virulence-associated factor, and its sialylation largely confers its ability to mediate cell adhesion, invasion, inflammation, and immune evasion.
Huan Wang, Lu Liu, Qi Cao, Weiting Mao, Yage Zhang, Xinyi Qu, Xuwang Cai, Yujin Lv, Huanchun Chen, Xiaojuan Xu, Xiangru Wang   +10 more
doaj   +1 more source

Using Synthetic Glycans to Investigate Anti‐Glycan Antibodies and Explore Their Medical Potential

Angewandte Chemie International Edition, Volume 65, Issue 39, 21 September 2026.
Anti‐glycan antibodies are essential in health and disease. Access to novel glycan structures paves the way for progress in antibody profiling for biomarker discovery, antibody development, and vaccine design. We summarize the strategies to synthesize and utilize synthetic glycans for the development and application of anti‐glycan antibodies in basic ...
Fabienne Weber, Aina Valenti, Jiří Ledvinka, Oren Moscovitz, Peter H. Seeberger   +4 more
wiley   +1 more source

Biological function of sialic acid and sialylation in human health and disease

Cell Death Discovery
Sialic acids are predominantly found at the terminal ends of glycoproteins and glycolipids and play key roles in cellular communication and function. The process of sialylation, a form of post-translational modification, involves the covalent attachment ...
Wengen Zhu, Yue Zhou, Linjuan Guo, Shenghui Feng   +3 more
doaj   +1 more source

Regulatory Mechanisms and Functions of Neural Sialylation in Diverse Biological Systems [PDF]

, 2020
Defects in sialylation cause numerous human pathologies including heart disease, cancer, immune system dysfunction, and neurological abnormalities.
Allen, Brooke Ashley
core   +1 more source

Increased branching and sialylation of N-linked glycans correlate with an improved pharmacokinetic profile for BAY 81–8973 compared with other full-length rFVIII products

, 2019
John M Teare,1 David S Kates,1 Anita Shah,2 Stephen Garger1 1Biological Development, Bayer US LLC Pharmaceuticals, Berkeley, CA, USA; 2Pharmacokinetics Pharmacodynamics Hematology, Bayer US LLC Pharmaceuticals, Whippany, NJ, USA Background: BAY 81 ...
Teare JM, Shah A, Kates DS, Garger S
core  

Deficient extravillous trophoblast invasion caused by impaired sialylation–Siglec-7 interaction contributes to recurrent pregnancy loss

Cell Death and Disease
Successful pregnancy requires precise immune interactions between fetal extravillous trophoblasts (EVT) and maternal decidual immune cells at the maternal–fetal interface.
Linyu Zhang, Ying Feng, Peng Wu, Liuyan Chen, Nan Jiang, Xue Ma, Qianhong Ma, Hao-Jie Lu, Xue Xiao, Fang Ma   +9 more
doaj   +1 more source