Results 1 to 10 of about 17,841 (204)

Expression of active human sialyltransferase ST6GalNAcI in Escherichia coli [PDF]

Microbial Cell Factories, 2009
Background The presence of terminal, surface-exposed sialic acid moieties can greatly enhance the in vivo half-life of glycosylated biopharmaceuticals and improve their therapeutic efficacy.
Schwartz Marc F, DeFrees Shawn, Carroll Sean, Skretas Georgios, Johnson Karl F, Georgiou George   +5 more
doaj   +5 more sources

The Emerging Role of Sialic Acids in Obesity and Diabetes: Molecular Mechanisms and Therapeutic Perspectives [PDF]

Biomolecules
Sialic acids are terminal monosaccharides that cap glycans on glycoconjugates. Accumulating clinical and experimental evidence shows that obesity, insulin resistance, and diabetes are accompanied by changes in sialic-acid levels. In these conditions, the
Xinyi Peng, Haojun Li, Qingwen Wang, Peng George Wang, Yang Ji   +4 more
doaj   +2 more sources

Possible involvement of sialidase and sialyltransferase activities in a stage-dependent recycling of sialic acid in some organs of type 1 and type 2 diabetic rats [PDF]

Frontiers in Endocrinology
BackgroundType 1 (T1D) and type 2 (T2D) diabetes lead to an aberrant metabolism of sialoglycoconjugates and elevated free serum sialic acid (FSSA) level.
Osas Graham Erhabor, Peter Obochi, Murtala Bindawa Isah, Mohammed Aliyu Usman, Ismaila Alhaji Umar, Mthokozisi B. C. Simelane, Mohammed Nasir Shuaibu, Md. Shahidul Islam, Mohammed Auwal Ibrahim   +8 more
doaj   +2 more sources

Glycosyltransferases: glycoengineers in human milk oligosaccharide synthesis and manufacturing [PDF]

Frontiers in Molecular Biosciences
Human milk oligosaccharides (HMOs) are a diverse group of complex carbohydrates that play crucial roles in infant health, promoting a beneficial gut microbiota, modulating immune responses, and protecting against pathogens.
Alanna S. Slater, Alanna S. Slater, Andrew G. McDonald, Rita M. Hickey, Gavin P. Davey   +4 more
doaj   +2 more sources

alpha2,3-sialyltransferase ST3Gal III modulates pancreatic cancer cell motility and adhesion in vitro and enhances its metastatic potential in vivo. [PDF]

PLoS ONE, 2010
BACKGROUND: Cell surface sialylation is emerging as an important feature of cancer cell metastasis. Sialyltransferase expression has been reported to be altered in tumours and may account for the formation of sialylated tumour antigens.
Marta Pérez-Garay, Beatriz Arteta, Lluís Pagès, Rafael de Llorens, Carme de Bolòs, Fernando Vidal-Vanaclocha, Rosa Peracaula   +6 more
doaj   +3 more sources

Stromal cells modulate innate immune cell phenotype and function in colorectal cancer via the Sialic acid/Siglec axis [PDF]

Journal for ImmunoTherapy of Cancer
Background The immunosuppressive tumor microenvironment reduces immune response effectiveness in stromal-rich tumors, including consensus molecular subtype 4 colorectal cancer (CRC).
Seán O Hynes, Laurence J Egan, Philip D Dunne, Oliver Treacy, Hannah Egan, Thomas Ritter, Margaret Sheehan, Aideen E Ryan, Linda Howard, Li Peng, Michael O’Dwyer, Lizhi Cao, Jenny Che, Shania M Corry, Niamh A Leonard, Aoife Canney, Eileen Reidy, Aoise O’Neill, Kevin Culligan, Norashikin Zakaria, Courtney Bull, Clodagh O’Meara, Anastasija Walsh, Aisling M Hogan   +23 more
doaj   +2 more sources

Sialyltransferase Inhibitors for the Treatment of Cancer Metastasis: Current Challenges and Future Perspectives

Molecules, 2021
Potent, cell-permeable, and subtype-selective sialyltransferase inhibitors represent an attractive family of substances that can potentially be used for the clinical treatment of cancer metastasis.
Ser John Lynon P. Perez, Chih-Wei Fu, Wen-Shan Li   +2 more
doaj   +1 more source

Multi-Faceted Effects of ST6Gal1 Expression on Precursor B-Lineage Acute Lymphoblastic Leukemia

Frontiers in Oncology, 2022
Normal early human B-cell development from lymphoid progenitors in the bone marrow depends on instructions from elements in that microenvironment that include stromal cells and factors secreted by these cells including the extracellular matrix ...
Mingfeng Zhang, Tong Qi, Lu Yang, Daniel Kolarich, Daniel Kolarich, Nora Heisterkamp   +5 more
doaj   +1 more source

An efficient and robust HPLC method to determine the sialylation levels of human epithelial cells.

PLoS ONE, 2022
Sialyltransferase, an enzyme responsible for attaching sialic acid to the cell surface, is reported to play a key role in cancer, making sialyltransferase a potential therapeutic target in drug development. Several methods have been developed to quantify
Hyo Jeong Kim, Stephanie Schweiker, Katie Powell, Stephan Levonis   +3 more
doaj   +1 more source

ST6Gal1: Oncogenic signaling pathways and targets

Frontiers in Molecular Biosciences, 2022
The Golgi-sialyltransferase ST6Gal1 (βgalactosidase α2,6 sialyltransferase 1), adds the negatively charged sugar, sialic acid, to the terminal galactose of N-glycosylated proteins.
Sajina GC, Susan L. Bellis, Anita B. Hjelmeland   +2 more
doaj   +1 more source