Sialidase and Sialyltransferase Inhibitors: Targeting Pathogenicity and Disease
Frontiers in Molecular Biosciences, 2021 Sialidases (SAs) and sialyltransferases (STs), the enzymes responsible for removing and adding sialic acid to other glycans, play essential roles in viruses, bacteria, parasites, and humans.
William H. D. Bowles, Tracey M. Gloster
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The trans-sialidase from Trypanosoma cruzi induces thrombocytopenia during acute Chagas' disease by reducing the platelet sialic acid contents [PDF]
, 2005 Strong thrombocytopenia is observed during acute infection with Trypanosoma cruzi, the parasitic protozoan agent of American trypanosomiasis or Chagas' disease.
Campetella, O. +4 more
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B cells suppress medullary granulopoiesis by an extracellular glycosylation-dependent mechanism
eLife, 2019 The immune response relies on the integration of cell-intrinsic processes with cell-extrinsic cues. During infection, B cells vacate the marrow during emergency granulopoiesis but return upon restoration of homeostasis.
Eric E Irons +5 more
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A new assay for determining ganglioside sialyltransferase activities lactosylceramide-2,3-sialyltransferase (SAT I) and monosialylganglioside-2,3-sialyltransferase (SAT IV). [PDF]
PLoS ONE, 2014 A new assay for the determination of lactosylceramide-2,3-sialyltransferase (SAT I, EC 2.4.99.9) and monosialoganglioside sialyltransferase (SAT IV, EC 2.4.99.2) is described.
Cynthia Q Sun +4 more
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Advances in Cancer Biology - Metastasis, 2021 Aberrant glycosylation, particularly sialylation is considered a significant characteristic of malignancy. Aberrant sialylation has been connected with several neoplastic disorders. The role of abnormal sialylation in oral cancer blood, on the other hand,
Mallikarjun Goni +5 more
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Combination of automated solid-phase and enzymatic oligosaccharide synthesis provides access to α(2,3)-sialylated glycans [PDF]
, 2015 A synthetic strategy combining automated solid-phase chemical synthesis and enzymatic sialylation was developed to access α(2,3)-sialylated glycans.
Fair, Richard J. +2 more
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Altered Sialylation and Sialyltransferase Expression in Gynecologic Cancers
Taiwanese Journal of Obstetrics & Gynecology, 2004 Sialic acids and their derivatives are ubiquitous at the terminal positions of the oligosaccharides of glycoproteins that play roles in a variety of biologic processes, such as cell-cell communication, cell-matrix interaction, adhesion, and protein ...
Peng-Hui Wang
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Molecular Therapy: Oncolytics, 2020 Follicular thyroid carcinoma (FTC) is a common endocrine malignancy with highly aggressive features. In this study, next-generation sequencing technology was used to identify aberrant expression of sialyltransferase (ST) family members in FTC.
Gaoran Xu +8 more
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Induced Stem Cells as a Novel Multiple Sclerosis Therapy. [PDF]
, 2016 Stem cell replacement is providing hope for many degenerative diseases that lack effective therapeutic methods including multiple sclerosis (MS), an inflammatory demyelinating disease of the central nervous system. Transplantation of neural stem cells or
Guan, Yang-Tai +3 more
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JIMD Reports, 2023 GM3 synthase deficiency (GM3SD) is caused by biallelic variants in ST3GAL5. The ganglioside GM3, enriched in neuronal tissues, is a component of lipid rafts and regulates numerous signaling pathways.
Natasha Rudy +7 more
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