Results 81 to 90 of about 17,841 (204)

Tumor sialylation impedes T cell mediated anti-tumor responses while promoting tumor associated-regulatory T cells [PDF]

, 2016
The increased presence of sialylated glycans on the tumor surface has been linked to poor prognosis, yet the effects on tumor-specific T cell immunity are hardly studied.
Boon, L. (Louis), Cornelissen, L.A.M. (Lenneke A.M.), Engels, S. (Steef), Geerts, D. (Dirk), Kooyk, Y. (Yvette) van, Perdicchio, M. (Maurizio), Streng-Ouwehand, I. (Ingeborg), Unger, W.W.J. (Wendy), Verstege, M.I. (Marleen I.)   +8 more
core   +2 more sources

Bioorthogonal Chemistry in Biomolecule Quantification: A Review of Reactions and Strategies

Chemistry – A European Journal, Volume 32, Issue 1, 2 January 2026.
This review summarizes the application of catalyst‐free bioorthogonal reactions: Staudinger ligation, strain promoted azide alkyne cycloaddition, inverse electron‐demand Diels–Alder, and 2‐cyanobenzothiazole cysteine condensation in the semi‐quantitative and quantitative analysis of biomolecules.
Mingze Yang, Shiqi Wang
wiley   +1 more source

Supplementary Figure S5 from An <i>In Vivo</i> Functional Screen Identifies ST6GalNAc2 Sialyltransferase as a Breast Cancer Metastasis Suppressor [PDF]

, 2023
Nirupa Murugaesu, Marjan Iravani, Antoinette van Weverwijk, Aleksandar Ívetic, Damian A. Johnson, Aristotelis Antonopoulos, Antony Fearns, Mariam Jamal‐Hanjani, David Sims, Kerry Fenwick, Costas Mitsopoulos, Qiong Gao, Nick Orr, Marketa Zvelebil, Stuart M. Haslam, Anne Dell, Helen Yarwood, Christopher J. Lord, Alan Ashworth, Clare M. Isacke   +19 more
openalex   +1 more source

Intestinal Neutral Ceramidase Deficiency Triggers Regulatory T Cell Response via Gd3 to Protect the Host from Intestinal Inflammation

Advanced Science, Volume 13, Issue 5, 27 January 2026.
Deletion of ASAH2 in intestinal epithelial cells induces the accumulation of ganglioside GD3 via regulating ST8SIA1. GD3 is identified as the glycolipid ligand for the inhibitory receptor Siglec‐E on macrophages. GD3/Siglec‐E ligation polarizes macrophages and promotes the proliferation of colonic ST2+ T regulatory cells via the induction of IL‐33. The
Zhishan Xu, Chao Lei, Mukesh K Sriwastva, Ting Wang, Amanguli Tuohongerbieke, Xiaotong Song, Collin Noud, Shannon Derkson, Yi Tan, Gerald Dryden, Craig J McClain, Zhongbin Deng   +11 more
wiley   +1 more source

Human β-galactoside α-2,3-sialyltransferase (ST3Gal III) attenuated Taxol-induced apoptosis in ovarian cancer cells by downregulating caspase-8 activity [PDF]

, 2009
Taxol triggers apoptosis in a variety of cancer cells, but it also upregulates cytoprotective proteins and/or pathways that compromise its therapeutic efficacy.
Choi, Mi-Ran, Day, Travis W., Huang, Su, Safa, Ahmad R.   +3 more
core   +2 more sources

The physiological and pathological effects of sphingolipid metabolism and signaling in the central nervous system

Brain Pathology, Volume 36, Issue 1, January 2026.
Sphingolipids are vital components of cell membranes. Metabolic disruptions of sphingolipids, including ceramide and sphingosine‐1‐phosphate, are linked to neurological disorders. This article summarizes the classification, structure, and metabolic processes of sphingolipids, and the physiological and pathological effects of sphingolipid metabolism and
Tian Li, Haoying He, Ejuan Zhang, Fengjiao Hu, Zhuo Wang, Jian Xu, Mengliu Zeng, Biwen Peng   +7 more
wiley   +1 more source

The alteration and role of glycoconjugates in Alzheimer’s disease

Frontiers in Aging Neuroscience
Alzheimer’s disease (AD) is a prevalent neurodegenerative disorder characterized by abnormal protein deposition. With an alarming 30 million people affected worldwide, AD poses a significant public health concern.
Yue Kang, Qian Zhang, Silu Xu, Yue Yu
doaj   +1 more source

Regulation of inflammatory signaling by the ST6Gal-I sialyltransferase.

PLoS ONE, 2020
The ST6Gal-I sialyltransferase, an enzyme that adds α2-6-linked sialic acids to N-glycosylated proteins, regulates multiple immunological processes. However, the contribution of receptor sialylation to inflammatory signaling has been under-investigated ...
Andrew T Holdbrooks, Katherine E Ankenbauer, Jihye Hwang, Susan L Bellis   +3 more
doaj   +1 more source

Sialyltransferases and Neuraminidases: Potential Targets for Cancer Treatment [PDF]

, 2022
Sagorika Nag, Abhimanyu Mandal, Aryaman Joshi, Neeraj Jain, Ravi Shanker Srivastava, Sanjay Singh, Arun Khattri   +6 more
openalex   +1 more source

Evidence for the involvement of lipid rafts localized at the ER-mitochondria associated membranes in autophagosome formation [PDF]

, 2016
Mitochondria-associated membranes (MAMs) are subdomains of the endoplasmic reticulum (ER) that interact with mitochondria. This membrane scrambling between ER and mitochondria appears to play a critical role in the earliest steps of autophagy.
Faggioni, Alberto, Gambardella, Lucrezia, Garofalo, Tina, Malorni, Walter, Manganelli, Valeria, Marconi, Matteo, Matarrese, Paola, Misasi, Roberta, Sorice, Maurizio, Tinari, Antonella   +9 more
core   +2 more sources