Results 71 to 80 of about 11,605 (209)
Accumulation of GD1α Ganglioside in MDA-MB-231 Breast Cancer Cells Expressing ST6GalNAc V
Molecules, 2015 α-Series gangliosides define a particular sub-class of glycosphingolipids containing sialic acid α2,6-linked to GalNAc residue that was isolated as a minor compound from the brain.
Sandy Vandermeersch +7 more
doaj +1 more source
Regulation of inflammatory signaling by the ST6Gal-I sialyltransferase.
PLoS ONE, 2020 The ST6Gal-I sialyltransferase, an enzyme that adds α2-6-linked sialic acids to N-glycosylated proteins, regulates multiple immunological processes. However, the contribution of receptor sialylation to inflammatory signaling has been under-investigated ...
Andrew T Holdbrooks +3 more
doaj +1 more source
Using Synthetic Glycans to Investigate Anti‐Glycan Antibodies and Explore Their Medical Potential
Angewandte Chemie International Edition, Volume 65, Issue 39, 21 September 2026.Anti‐glycan antibodies are essential in health and disease. Access to novel glycan structures paves the way for progress in antibody profiling for biomarker discovery, antibody development, and vaccine design. We summarize the strategies to synthesize and utilize synthetic glycans for the development and application of anti‐glycan antibodies in basic ...
Fabienne Weber +4 more
wiley +1 more source
Expression of active human sialyltransferase ST6GalNAcI in
Microbial Cell Factories, 2009 Background The presence of terminal, surface-exposed sialic acid moieties can greatly enhance the in vivo half-life of glycosylated biopharmaceuticals and improve their therapeutic efficacy.
Schwartz Marc F +5 more
doaj +1 more source
Supplementary Data from Protein Sialylation by Sialyltransferase Involves Radiation Resistance
, 2008 Supplementary Data from Protein Sialylation by Sialyltransferase Involves Radiation ...
Minyoung Lee (484115) +3 more
core +1 more source
α-2,3-Sialyltransferase Functionalized Magnetic Nanoparticle and its Application
, 2011 [[abstract]]本論文中為發展蛋白質的快速純化和酵素的重複使用，以pTYB1及pTXB1此intein系列之載體分別表達，eGFP-intein及α-2,3-sialyltransferase-intein這兩種融合蛋白，利用intein 之特性，分別在eGFP及α-2,3-sialyltransferase之C端進行修飾，以利其專一位相固化於磁性奈米粒子上。透過磁鐵與磁性奈米粒子之間的磁力吸引，可從表現完之混合蛋白質，快速的純化出eGFP及α-2,3-sialyltransferase ...
柯嘉玲
core
Quantum Mechanics/Molecular Mechanics Study of the Sialyltransferase Reaction Mechanism
, 2016 The sialyltransferase is an enzyme that transfers the sialic acid moiety from cytidine 5′-monophospho-N-acetyl-neuraminic acid (CMP-NeuAc) to the terminal position of glycans.
Masanori Tachikawa (331224) +2 more
core +1 more source
BiomoleculesSialic acids are terminal monosaccharides that cap glycans on glycoconjugates. Accumulating clinical and experimental evidence shows that obesity, insulin resistance, and diabetes are accompanied by changes in sialic-acid levels. In these conditions, the
Xinyi Peng +4 more
doaj +1 more source
Cancer Management and Research, 2018 Christian Garbar,1,2 Corinne Mascaux,1,2 Yacine Merrouche,1,2 Armand Bensussan3 1Biopathology Department, Institut Jean Godinot – Unicancer, Reims, France; 2DERM-I-C EA7319, Université de Reims Champagne – Ardenne, Reims, France ...
Garbar C +3 more
doaj
Recombinant Sialyltransferase Infusion Mitigates Infection-Driven Acute Lung Inflammation
Frontiers in Immunology, 2019 Inappropriate inflammation exacerbates a vast array of chronic and acute conditions with severe health risks. In certain situations, such as acute sepsis, traditional therapies may be inadequate in preventing severe organ damage or death.
Mehrab Nasirikenari +7 more
doaj +1 more source