Results 81 to 90 of about 11,605 (209)
Movement Disorders, Volume 41, Issue 9, Page 2349-2356, September 2026.Abstract Background Lysosomal dysfunction is central to Parkinson's disease (PD) pathogenesis, with GBA1 representing the strongest established genetic risk factor. Numerous other genes involved in lysosomal sphingolipid, glycosphingolipid, and ceramide metabolism have been proposed as contributors to PD, highlighting the need for genetic analyses ...
Konstantin Senkevich +21 more
wiley +1 more source
Journal of Lipid Research, 1989 Six naturally occurring and three synthetic molecular species of lactosylceramide (LacCer) were used to examine the molecular species specificity of CMP-N-acetylneuraminate:lactosylceramide alpha 2,3-sialyltransferase in a Golgi-rich fraction of rat ...
H Kadowaki +3 more
doaj +1 more source
Biosynthesis and intracellular transport of alpha-2,6-sialyltransferase in rat hepatoma cells.
, 1992 We investigated biosynthesis, intracellular transport and release of beta-galactoside alpha-2,6-sialyltransferase in a dexamethasone-inducible rat hepatoma cell line.
Bosshart H, Berger EG
core +1 more source
Sialylmotifs of sialyltransferases.
Indian journal of biochemistry & biophysics, 1997 The sialyl moiety of sialylated glycoconjugates expressed on the cell surface are increasingly recognized as the key determinants of various biological recognition events. The transfer of sialic acid to these glycoconjugates are catalyzed by sialyltransferases, a group of 15 or more Golgi enzymes.
A K, Datta, J C, Paulson
openaire +1 more source
, 2016 A multifunctional sialyltransferase has been cloned from Pasteurella multocida strain P-1059 and expressed in E. coli as a truncated C-terminal His6-tagged recombinant protein (tPm0188Ph).
Harshal Chokhawala (2050390) +8 more
core +1 more source
Human liver and human placenta both contain CMP-NeuAc:Galβ1→4GlcNAc-R α2→3- as well as α2→6-sialyltransferase activity [PDF]
, 1992 A high pH anion exchange chromatographic (HPAEC) system for the separation of isomeric sialo-oligosaccharide products was developed. Employing this system, using Galβ1→4GlcNAcβ1→2Manα1→6Manβ1→4GlcNAc as a substrate, a Galβ1→4GlcNAc-R α2→3 ...
Nemansky, Martin +7 more
core +1 more source
Radiation Oncology, 2012 Background Previously, we found that β-galactoside α2,6-sialyltransferase (ST6Gal I), an enzyme that adds sialic acids to N-linked oligosaccharides of glycoproteins and is frequently overexpressed in cancer cells, is up-regulated by ionizing radiation ...
Lee Minyoung +3 more
doaj +1 more source
PmST2: A novel Pasteurella multocida glycolipid α2-3-sialyltransferase
, 2011 Pasteurella multocida (Pm) is a multi-species pathogen that causes diseases in animals and humans. Sialyltransferase activity has been detected in multiple Pm strains and sialylation has been shown to be important for the pathogenesis of Pm.
Lau, Kam +9 more
core +1 more source
, 1989 The sialyltransferase activities of 10 human colorectal specimens were compared with those of the corresponding adjacent normal mucosa. Using asialofetuin as an acceptor we found, in tumor tissues of 9 out of 10 patients, an increased sialyltransferase ...
Serafini, F +5 more
core +1 more source
Biological Research, 2015 BACKGROUND: Glycoproteins play a critical role in the cellular activities of eukaryotes. Sialic acid is typically the outermost monosaccharide of glycolipids and glycoproteins, and is necessary for normal development.
Yangui Liang +4 more
doaj +1 more source