Results 81 to 90 of about 10,746,438 (360)

A Phase 3 Trial of l‐Glutamine in Sickle Cell Disease

New England Journal of Medicine, 2018
BACKGROUND Oxidative stress contributes to the complex pathophysiology of sickle cell disease. Oral therapy with pharmaceutical‐grade l‐glutamine (USAN, glutamine) has been shown to increase the proportion of the reduced form of nicotinamide adenine ...
Y. Niihara, Scott T. Miller, J. Kanter, S. Lanzkron, Wally R. Smith, L. Hsu, V. Gordeuk, K. Viswanathan, S. Sarnaik, I. Osunkwo, Edouard Guillaume, S. Sadanandan, L. Sieger, Joseph L. Lasky, E. Panosyan, Osbourne A. Blake, T. New, R. Bellevue, Lan T. Tran, R. Razon, C. Stark, L. Neumayr, E. Vichinsky   +22 more
semanticscholar   +1 more source

Online decision aids for contraceptive choices in women with chronic conditions: A systematic review

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Background Women with chronic conditions face increased risks of unintended pregnancy and adverse maternal and perinatal outcomes. Tailored, online contraceptive decision aids might improve informed decision‐making and support reproductive health by promoting patient‐centered care in this population.
Begashaw Melaku Gebresillassie, Nicole Doley, Melissa L. Harris   +2 more
wiley   +1 more source

Mechanistic Consequences of Piezo1 Gain‐of‐Function Variants for Decreased Red Cell Survival in Hereditary Xerocytosis

American Journal of Hematology, EarlyView.
Asya Makhro, Rick Huisjes, Elena Seiler, Min Qiao, Marije Bartels, Inga Hegemann, Patrick Eppenberger, Nicole Bender, Isabel Dorn, Anna Bogdanova, Richard van Wijk, Lars Kaestner   +11 more
wiley   +1 more source

The impact of low‐dose aspirin on hemoglobin levels in pregnancy: A secondary analysis of a randomized controlled trial for prevention of hypertensive disorders of pregnancy

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objectives This study evaluates the association of low‐dose aspirin (LDA) with hemoglobin (Hb) levels during pregnancy and explores how changes in Hb levels relate to hypertensive disorders of pregnancy (HDP). Methods This secondary analysis of a randomized controlled trial comprised 249 pregnant women recruited from a regional hospital in ...
N. M. Ngcobo, V. Dorsamy, C. Bagwandeen, P. Z. Mkhize, J. Moodley   +4 more
wiley   +1 more source

Sickle-cell disease [PDF]

Nature, 2014
Lauren, Gravitz, Stephen, Pincock
openaire   +4 more sources

Invasive Pulmonary Aspergillosis in a Sickle Cell Patient Transplant Recipient: A Successful Treatment

Mediterranean Journal of Hematology and Infectious Diseases, 2015
Sickle Cell Anaemia (SCA) is the most common inherited blood disorder and is associated with severe morbidity and decreased survival. Allogeneic Haematopoietic Stem Cell Transplantation (HSCT) is the only curative approach.
Katia Paciaroni, Gioia De Angelis, Cristiano Gallucci, Cecilia Alfieri, Michela Ribersani, Andrea Roveda, Antonella Isgrò, Marco Marziali, Ivan Pietro Aloi, Alessandro Inserra, Javid Gaziev, Pietro Sodani, Guido Lucarelli   +12 more
doaj   +1 more source

Highly efficient editing of the β-globin gene in patient-derived hematopoietic stem and progenitor cells to treat sickle cell disease

Nucleic Acids Research, 2019
Sickle cell disease (SCD) is a monogenic disorder that affects millions worldwide. Allogeneic hematopoietic stem cell transplantation is the only available cure.
S. H. Park, Ciaran M. Lee, D. Dever, Timothy H. Davis, J. Camarena, W. Srifa, Yankai Zhang, Alireza Paikari, Alicia K Chang, M. Porteus, V. Sheehan, Gang Bao   +11 more
semanticscholar   +1 more source

Frequency and Associated Factors of Clotted and Hemolyzed Samples in South Gonder Hospitals, Ethiopia: A Multicenter Cross‐Sectional Study, 2023

Journal of Clinical Laboratory Analysis, EarlyView.
This study, conducted in South Gonder hospitals in Ethiopia, investigated the prevalence and causes of clotted and hemolyzed blood samples submitted for hematological testing. The findings revealed a high rate of sample quality issues, with significant associations identified between pre‐analytical factors like collection technique and sample integrity.
Birhanemaskal Malkamu, Getaneh Atikilt Yemata, Andargachew Almaw, Ayenew Assefa, Birhanu Getie, Teklehaimanot Kiros, Mulat Erkihun, Shewaneh Damtie, Tegenaw Tiruneh, Berhanu Abebaw Mekonnen, Meron Asmamaw Alemayehu, Abraham Teym, Abathun Temesgen, Gashaw Melkie Bayeh, Almaw Genet Yeshiwas, Rahel Mulatie Anteneh, Melkamu Aderajew Zemene, Tesfaneh Shimels, Chalachew Yenew, Wolde Melese Ayele, Ahmed Fentaw Ahmed, Assefa Andargie Kassa, Tilahun Degu Tsega, Chalachew Abiyu Ayalew, Sintayehu Simie Tsega, Zeamanuel Anteneh Yigzaw, Amare Genetu Ejigu, Wondimnew Desalegn Addis, Getasew Yirdaw, Kalaab Esubalew Sharew, Daniel Adane, Samuel Berihun Dagnew, Gebyaw Arega, Habitamu Mekonen   +33 more
wiley   +1 more source

P-058: INFLUENCE OF HEME OXYGENASE-I GENE PROMOTER POLYMORPHISM ON THE VASO OCCLUSIVE CRISIS OF SICKLE CELL ANEMIA PATIENTS OF EASTERN INDIA

HemaSphere, 2022
MEHER S., MOHANTY P., PATEL S., DAS K., SAHOO S., DEHURY S., DASH B.   +6 more
doaj   +1 more source

Insight into the complex pathophysiology of sickle cell anaemia and possible treatment

European Journal of Haematology, 2019
Sickle cell anaemia (SCA) is the consequence of abnormal haemoglobin production due to an inherited point mutation in the β‐globin gene. The resulting haemoglobin tetramer is poorly soluble when deoxygenated, and when this is prolonged, intracellular ...
A. Piccin, C. Murphy, E. Eakins, M. Rondinelli, M. Daves, C. Vecchiato, D. Wolf, C. Mc Mahon, O. Smith   +8 more
semanticscholar   +1 more source