Results 131 to 140 of about 1,827,024 (396)

Barriers to Pediatric Sickle Cell Disease Guideline Recommendations. [PDF]

, 2019
National guidelines recommend that providers counsel all patients with sickle cell anemia about hydroxyurea (HU) therapy and screen children with sickle cell anemia annually for the risk of stroke with transcranial Doppler (TCD).
Bardach, Naomi S, Cabana, Michael D, Kanter, Julie, Marsh, Anne M, Rowland, Michael, Stemmler, Peggy, Treadwell, Marsha J   +6 more
core  

Patients' views on improving sickle cell disease management in primary care: focus group discussion. [PDF]

, 2012
OBJECTIVES: To assess sickle cell disease (SCD) patient and carer perspectives on the primary care services related to SCD that they receive from their general practitioner (GP).
Aljuburi, G, Anie, K, Banarsee, R, Green, SA, Majeed, A, Ndive, C, Nkohkwo, A, Ojeer, P, Okoye, NO, Oni, L, Phekoo, KJ   +10 more
core   +1 more source

Severe acute respiratory syndrome coronavirus 2 transaminase elevation likely of non‐hepatic origin, with protection from older age and vaccination

JPGN Reports, EarlyView.
Abstract Severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) has known liver tropism. Multiple reports and studies demonstrated liver injury early in the pandemic. This retrospective cross‐sectional comparison evaluates predictors of transaminase elevation during acute SARS‐CoV2 infection, with particular interest in evaluating whether ...
Antonia F. Ovale, Cassandra Charles, Janet Rosenbaum, Priscila Villalba‐Davila, Shagun Sharma, Saema Khandakar, Thomas Wallach   +6 more
wiley   +1 more source

Base editing of haematopoietic stem cells rescues sickle cell disease in mice

Nature, 2021
Gregory A. Newby, J. Yen, Kaitly J. Woodard, Thiyagaraj Mayuranathan, C. Lazzarotto, Yichao Li, Heather Sheppard-Tillman, Shaina N. Porter, Yu Yao, Kalin Mayberry, Kelcee A. Everette, Yoon-Young Jang, Christopher J. Podracky, Elizabeth Thaman, Christophe Lechauve, Akshay Sharma, Jordana M. Henderson, M. Richter, K. Zhao, Shannon M Miller, Tina Wang, Luke W. Koblan, Anton P. McCaffrey, J. Tisdale, T. Kalfa, S. Pruett-Miller, S. Tsai, M. Weiss, David R. Liu   +28 more
semanticscholar   +1 more source

Reducing Surgery for Pediatric Posttonsillectomy Hemorrhage Using Tranexamic Acid: A Quality Improvement Initiative

Otolaryngology–Head and Neck Surgery, EarlyView.
Abstract Objective Evaluate the use of tranexamic acid (TXA) and observation as a management option for pediatric patients presenting with posttonsillectomy hemorrhage (PTH). Study Design Retrospective analysis of a prospectively implemented quality improvement initiative with a historical control comparison group. Setting Tertiary children's hospital.
Laura A. Petrauskas, Janavi Sethurathnam, Ansley J. Kunnath, Rahul K. Sharma, John Ceremsak, Ryan H. Belcher, James D. Phillips, Jay A. Werkhaven, Amy S. Whigham, Lyndy J. Wilcox, Christopher T. Wootten, Frank W. Virgin, Jason S. Park   +12 more
wiley   +1 more source

SICKLE CELL DISEASE - CASE REPORTS

Journal of Nepal Medical Association, 2003
Sickle cell diseases are inherited hematological diseases, prevalent in certain parts of the world. We report two cases of sickle cell diseases, first being sickle cell b-thalassaemia and second homozygous sickle cell disease (SS).
Ram Chandra Adhikari, T B Shrestha, R B Shrestha, R C Subedi, K P Parajuli, S Dali   +5 more
doaj   +1 more source

The Evolving Pharmacotherapeutic Landscape for the Treatment of Sickle Cell Disease. [PDF]

, 2020
Sickle cell disease (SCD) is an extremely heterogeneous disease that has been associated with global morbidity and early mortality. More effective and inexpensive therapies are needed.
Ballas, Samir K
core   +1 more source

Steroids for Pediatric Adenotonsillectomy Pain—A Prospective Multicenter Randomized Trial

Otolaryngology–Head and Neck Surgery, EarlyView.
Abstract Objective To compare postoperative caregiver‐reported pain control of two steroid regimens following pediatric adenotonsillectomy. Secondary objectives assessed differences in analgesic use, return to normal diet, caregiver calls, adverse effects, and emergency room (ER) visits. Study Design Prospective randomized pragmatic trial.
Kevin D. Pereira, Wiktoria A. Gocal, Anna V. Borodianski, Mary E. Williamson, Hengameh K. Behzadpour, Sonal Saraiya, Diego A. Preciado, Amal Isaiah   +7 more
wiley   +1 more source

Blood Rheology: Key Parameters, Impact on Blood Flow, Role in Sickle Cell Disease and Effects of Exercise

Frontiers in Physiology, 2019
Blood viscosity is an important determinant of local flow characteristics, which exhibits shear thinning behavior: it decreases exponentially with increasing shear rates. Both hematocrit and plasma viscosity influence blood viscosity.
E. Nader, Sarah C. Skinner, M. Romana, R. Fort, Nathalie Lemonne, N. Guillot, A. Gauthier, S. Antoine-Jonville, C. Renoux, M. Hardy-Dessources, E. Stauffer, P. Joly, Y. Bertrand, P. Connes   +13 more
semanticscholar   +1 more source

Gas Chromatography‐Mass Spectrometry Analysis, Genoprotective, and Antioxidant Potential of Curio radicans (L. f.) P.V. Heath

ChemistryOpen, EarlyView.
The ethyl acetate extract of Curio radicans is found to contain a higher proportion of bioactive compounds (55% vs 30% in the ethanolic extract) by gas chromatography‐mass spectrometry, and it exhibits stronger antioxidant activity in the DPPH assay (75% vs 65% inhibition) as well as clear genoprotective effects against H2O2‐induced DNA damage ...
Muhammad Naseer, Muhammad Adil, Sarir Ahmad, Mikhlid H. Almutairi, Abdulwahed Fahad Alrefaei, Sajid Ali, Fayaz Asad   +6 more
wiley   +1 more source