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Bacterial Infection in the Sickle Cell Population: Development and Enabling Factors
Microorganisms, 2023 The high frequency of bacterial infections represents a major threat to public health. In developing countries, they are still responsible for significant morbidity and mortality in pediatric populations with sickle cell disease, particularly in children
Lucrèce M. Délicat-Loembet +3 more
doaj +1 more source
Treatment of dental complications in sickle cell disease. [PDF]
, 2016 BACKGROUND: Sickle cell disease is the most common single gene disorder and the commonest haemoglobinopathy found with high prevalence in many populations across the world.
Abas, Adinegara B L +3 more
core +2 more sources
Clinical Medicine, 2001 SCD is a major health problem requiring lifelong multidisciplinary care to manage the wide range of medical and social consequences. A number of new approaches offer the potential to have an impact on the natural history of this disease.
Anne Yardumian, Charles Crawley
openaire +3 more sources
Reduced sensitivity of the ferroportin Q248H mutant to physiological concentrations of hepcidin
Haematologica, 2013 Ferroportin Q248H mutation has an allele frequency of 2.2–13.4% in African populations and is associated with a mild tendency to increased serum ferritin in the general population. Some investigators have reported that ferroportin Q248H is degraded after
Sergei Nekhai +9 more
doaj +1 more source
Burden of sickle cell trait and disease in the Uganda Sickle Surveillance Study (US3): a cross-sectional study [PDF]
, 2016 Background Sickle cell disease contributes substantially to mortality in children younger than 5 years in sub-Saharan Africa. In Uganda, 20 000 babies per year are thought to be born with sickle cell disease, but accurate data are not available. We did
A Howard, Thad +10 more
core +1 more source
Recent Advances in the Treatment of Sickle Cell Disease
Frontiers in Physiology, 2020 Sickle cell anemia (SCA) was first described in the Western literature more than 100 years ago. Elucidation of its molecular basis prompted numerous biochemical and genetic studies that have contributed to a better understanding of its pathophysiology ...
Gabriel Salinas Cisneros, S. Thein
semanticscholar +1 more source
Disease knowledge and health literacy in parents of children with sickle cell disease
eJHaem, 2023 We aimed to (1) describe sickle cell disease (SCD) knowledge and health literacy levels in parents of children with SCD, (2) examine associations with socio‐demographic factors and (3) analyse the association with hospital admissions and frequency of ...
Bonaventure G. Ikediashi +3 more
doaj +1 more source
Frontiers in Genetics, 2023 Introduction: Sickle Cell Disease (SCD) causes significant morbidity and mortality particularly in sub-Saharan Africa (SSA) where it contributes to early childhood deaths.
Vivian Paintsil +15 more
doaj +1 more source
Haemoglobinopathies and newborn haemoglobinopathy screening in Germany. [PDF]
, 2009 Germany has been an immigration country since the early 1950s. In December 2007, 6.7 million non-German citizens lived in the country. However, the total number of citizens with a migration background is 15–20 million, about 9 million of whom come ...
Dickerhoff, R. +2 more
core +1 more source
The Vaso-Occlusive Pain Crisis in Sickle Cell Disease: Definition, Pathophysiology, and Management.
European Journal of Haematology, 2020 Early diagnosis, treatment, and prevention of a vaso-occlusive crisis (VOC) is critical to the management of patients with sickle cell disease. It is essential to differentiate between VOC-associated pain and chronic pain, hyperalgesia, neuropathy, and ...
D. Darbari, V. Sheehan, S. Ballas
semanticscholar +1 more source