Results 1 to 10 of about 429,758 (251)
Journal of Pathology of Nepal, 2013 Background: Sickle Hemoglobin is the most common pathological hemoglobin mutation worldwide which forms sickle shape or elongated forms on deoxygenation.
A Shrestha, S Karki
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Rapid and inefficient kinetics of sickle hemoglobin fiber growth. [PDF]
Sci Adv, 2019 Nanoscale analysis reveals the rapid and inefficient sickle hemoglobin self-assembly process. In sickle cell disease, the aberrant assembly of hemoglobin fibers induces changes in red blood cell morphology and stiffness, which leads to downstream ...
Castle BT, Odde DJ, Wood DK.
europepmc +2 more sources
Rational modification of vanillin derivatives to stereospecifically destabilize sickle hemoglobin polymer formation. [PDF]
Acta Crystallogr D Struct Biol, 2018 Increasing the affinity of hemoglobin for oxygen represents a feasible and promising therapeutic approach for sickle cell disease by mitigating the primary pathophysiological event, i.e.
Deshpande TM +8 more
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Discovery of GBT440, an Orally Bioavailable R-State Stabilizer of Sickle Cell Hemoglobin
ACS Medicinal Chemistry Letters, 2017 We report the discovery of a new potent allosteric effector of sickle cell hemoglobin, GBT440 (36), that increases the affinity of hemoglobin for oxygen and consequently inhibits its polymerization when subjected to hypoxic conditions.
Matthew P. Jacobson +2 more
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Association of Sickle Cell Trait With Hemoglobin A1c in African Americans
JAMA - Journal of the American Medical Association, 2017 Importance Hemoglobin A1c (HbA1c) reflects past glucose concentrations, but this relationship may differ between those with sickle cell trait (SCT) and those without it.
Rakhi P Naik, James F. Wilson, Simin Liu
exaly +2 more sources
Proceedings of the National Academy of Sciences of the United States of America, 2019 Significance Sickle cell disease is the first “molecular disease” described more than 100 years ago. All morbidity and mortality are ultimately caused by polymerization of the variant sickle hemoglobin molecule in red blood cells (RBCs). However, despite
David K Wood +2 more
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Candidate Sequence Variants and Fetal Hemoglobin in Children With Sickle Cell Disease Treated With Hydroxyurea [PDF]
PLoS ONE, 2013 Fetal hemoglobin level is a heritable complex trait that strongly correlates swith the clinical severity of sickle cell disease. Only few genetic loci have been identified as robustly associated with fetal hemoglobin in patients with sickle cell disease,
Lorraine Clark +2 more
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Genetic variants and cell-free hemoglobin processing in sickle cell nephropathy
Haematologica, 2015 Intravascular hemolysis and hemoglobinuria are associated with sickle cell nephropathy. ApoL1 is involved in cell-free hemoglobin scavenging through association with haptoglobin-related protein.
Santosh L. Saraf +10 more
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Treatment of sickle cell disease by increasing oxygen affinity of hemoglobin.
Blood, 2021 The issue of treating sickle cell disease with drugs that increase hemoglobin oxygen affinity has come to the fore with the FDA approval in 2019 of voxelotor, the only anti-sickling drug approved since hydroxyurea in 1998.
E. Henry +11 more
semanticscholar +1 more source
Elastic property of sickle and normal hemoglobin protein: Molecular dynamics
AIP Advances, 2022 This work focuses on identifying the conformational stability and binding components in sickle and normal hemoglobin to explore the elastic properties and realize the stiffness by using molecular dynamics simulation. Our investigation shows that a larger
Jhulan Powrel, Narayan Prasad Adhikari
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